Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1977-2-26
pubmed:abstractText
One hundred and fifty-two biopsies from serologically HBsAg positive and negative patients with liver disease were studied in immunofluorescence: for the presence of the surface (HBs) and the core (HBc) antigenic determinants foeterminants of the hepatitis B virus, of immunoglobulins and complement (C) deposits, and for the capacity to fix human C. Circumstantial evidence is presented suggesting that HBc immune-complexes are a relevant feature in the establishment and progression of chronic HBSAg liver disease. C fixation by liver cells was shown in all HBC positive patients with chronic hepatitis; an active form was present in every case, except two with a persistent hepatitis, an inverse ratio of HBc to C binding fluorescence being noted between active chronic hepatitis and cirrhotic patients. HBc without C fixation was observed in only three patients in the incubation phase of infectious hepatitis. IgG deposits were often found in HBc containing, C fixing nuclei. No C binding or IgG deposits were observed in acute self-limited type B hepatitis, in serologically positive patients with normal liver or minimal histological lesions, with and without HBs cytoplasmic fluorescence in their biopsy, or in serologically negative individuals.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/1001973-1089835, http://linkedlifedata.com/resource/pubmed/commentcorrection/1001973-13563554, http://linkedlifedata.com/resource/pubmed/commentcorrection/1001973-13986422, http://linkedlifedata.com/resource/pubmed/commentcorrection/1001973-4110684, http://linkedlifedata.com/resource/pubmed/commentcorrection/1001973-4111197, http://linkedlifedata.com/resource/pubmed/commentcorrection/1001973-4126916, http://linkedlifedata.com/resource/pubmed/commentcorrection/1001973-4143591, http://linkedlifedata.com/resource/pubmed/commentcorrection/1001973-4175170, http://linkedlifedata.com/resource/pubmed/commentcorrection/1001973-4359686, http://linkedlifedata.com/resource/pubmed/commentcorrection/1001973-4628111, http://linkedlifedata.com/resource/pubmed/commentcorrection/1001973-51345, http://linkedlifedata.com/resource/pubmed/commentcorrection/1001973-60776
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0017-5749
pubmed:author
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
837-43
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1976
pubmed:articleTitle
Complement fixing hepatitis B core antigen immune complexes in the liver of patients with HBs antigen positive chronic disease.
pubmed:publicationType
Journal Article