Linked Life Data

PF13866.1

Source:http://linkedlifedata.com/resource/pfam/family/PF13866.1

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
family:comment
SAP30 is a subunit of the histone deacetylase complex, and thisdomain is a zinc-finger. Solution of the structure shows a novel fold comprising two beta-strands and two alpha-helices with the zinc organising centre showing remote resemblance to the treble clef motif. In silico analysis of the structure revealed a highly conserved surface dominated by basic residues. NMR-based analysis of potential ligands for the SAP30 zn-finger motif indicated a strong preference for nucleic acid substrates. The zinc-finger of SAP3 probably functions as a double-stranded DNA-binding motif, thereby expanding the known functions of both SAP30 and the mammalian Sin3 co-repressor complex [1].
family:id
zf-SAP30
family:description
SAP30 zinc-finger
family:authorList
Coggill P
family:familyType
Domain
family:pubmed
family:protein