Source:http://linkedlifedata.com/resource/lhgdn/geneRifSource
| Subject | Predicate | Object | Context |
|---|---|---|---|
| lhgdn:association:23051 | lhgdn:geneRifSource | action of clioquinol on several age-dependent neurodegenerative diseases with distinct etiologies might result from a slowing down of the aging process through action of the drug on CLK-1. | lld:lhgdn |
| lhgdn:association:58848 | lhgdn:geneRifSource | The fat-1 gene expression inhibited prostate cancer cell proliferation via reduction of GSK-3beta phosphorylation and subsequent down-regulation of both beta-catenin and cyclin D1. | lld:lhgdn |
| lhgdn:association:53914 | lhgdn:geneRifSource | Nir2, a human homolog of Drosophila melanogaster retinal degeneration B protein, is essential for cytokinesis. | lld:lhgdn |
| lhgdn:association:13585 | lhgdn:geneRifSource | Data demonstrate that the Drosophila homologs of mixed-lineage leukemia protein and host cell factor 1, called Trithorax and dHCF, are both cleaved by Drosophila taspase 1. | lld:lhgdn |
| lhgdn:association:3522 | lhgdn:geneRifSource | These results demonstrate that scl is an important mediator of the ability of AML1-ETO to reprogram hematopoietic cell fate decisions, suggesting that scl may be an important contributor to AML1-ETO-associated leukemia. | lld:lhgdn |
| lhgdn:association:35932 | lhgdn:geneRifSource | The spectrum of disorders generated by morpholino inhibition and the more severe defects (microphthalmia and anophthalmia) observed at higher doses illustrate the key role of GDF6 in ocular development. | lld:lhgdn |
| lhgdn:association:406 | lhgdn:geneRifSource | A significant increase of stromal cell-derived factor-1alpha and CXCR4 was observed in protein extracts of idiopathic inflammatory myopathies in comparison with normal controls. | lld:lhgdn |
| lhgdn:association:62588 | lhgdn:geneRifSource | Chk1 appears to help defend genomic integrity through effects on several other pathways, including Fanconi anemia proteins, the mitotic spindle, and transcription of cell cycle-related genes [review] | lld:lhgdn |
| lhgdn:association:61936 | lhgdn:geneRifSource | Immunity to CD30 could play a role in Marek disease lymphoma regression. | lld:lhgdn |
| lhgdn:association:61960 | lhgdn:geneRifSource | Immunity to CD30 could play a role in Marek disease lymphoma regression. | lld:lhgdn |
| lhgdn:association:62603 | lhgdn:geneRifSource | 26 new mutations in RP2 and RPGR patients with X-linked Retinitis Pigmentosa. | lld:lhgdn |
| lhgdn:association:8868 | lhgdn:geneRifSource | Primary role for IL-1beta and TNF-alpha in the triggering of preterm labor associated with inflammation or infection. | lld:lhgdn |
| lhgdn:association:9009 | lhgdn:geneRifSource | Primary role for IL-1beta and TNF-alpha in the triggering of preterm labor associated with inflammation or infection. | lld:lhgdn |
| lhgdn:association:9034 | lhgdn:geneRifSource | Primary role for IL-1beta and TNF-alpha in the triggering of preterm labor associated with inflammation or infection. | lld:lhgdn |
| lhgdn:association:47906 | lhgdn:geneRifSource | Primary role for IL-1beta and TNF-alpha in the triggering of preterm labor associated with inflammation or infection. | lld:lhgdn |
| lhgdn:association:48078 | lhgdn:geneRifSource | Primary role for IL-1beta and TNF-alpha in the triggering of preterm labor associated with inflammation or infection. | lld:lhgdn |
| lhgdn:association:48117 | lhgdn:geneRifSource | Primary role for IL-1beta and TNF-alpha in the triggering of preterm labor associated with inflammation or infection. | lld:lhgdn |
| lhgdn:association:42734 | lhgdn:geneRifSource | Characterizes the hamster ortholog and suggests that it may modulate the ability of the proteasome to degrade retroviral cores upon cellular infection. | lld:lhgdn |
| lhgdn:association:63161 | lhgdn:geneRifSource | A2M-D allele played a weak Alzheimer disease protective role, and APOE-E4 and A2M-G alleles might act synergistically in Alzheimer disease risk for mainland Han Chinese. | lld:lhgdn |
| lhgdn:association:63150 | lhgdn:geneRifSource | The risk of symptomatic thromboembolism was significantly increased with elevated alpha2MG levels. | lld:lhgdn |
| lhgdn:association:63125 | lhgdn:geneRifSource | paclitaxel affected human leukemia HL-60 cells arylamine N-acetyltransferase (NAT) activity and DNA-2-aminofluorene adduct formation. | lld:lhgdn |
| lhgdn:association:55122 | lhgdn:geneRifSource | It is unlikely that the NAT1*10 or NAT2 rapid/intermediate genotypes are related to stomach cancer risk. | lld:lhgdn |
| lhgdn:association:63105 | lhgdn:geneRifSource | It is unlikely that the NAT1*10 or NAT2 rapid/intermediate genotypes are related to stomach cancer risk. | lld:lhgdn |
| lhgdn:association:55135 | lhgdn:geneRifSource | genetic polymorphisms of NAT1 and NAT2 have no independent effect on breast cancer risk, but they modulate breast cancer risk in the presence of GSTM1 and GSTT1 null genotypes. | lld:lhgdn |
| lhgdn:association:55177 | lhgdn:geneRifSource | genetic polymorphisms of NAT1 and NAT2 have no independent effect on breast cancer risk, but they modulate breast cancer risk in the presence of GSTM1 and GSTT1 null genotypes. | lld:lhgdn |
| lhgdn:association:57729 | lhgdn:geneRifSource | genetic polymorphisms of NAT1 and NAT2 have no independent effect on breast cancer risk, but they modulate breast cancer risk in the presence of GSTM1 and GSTT1 null genotypes. | lld:lhgdn |
| lhgdn:association:57827 | lhgdn:geneRifSource | genetic polymorphisms of NAT1 and NAT2 have no independent effect on breast cancer risk, but they modulate breast cancer risk in the presence of GSTM1 and GSTT1 null genotypes. | lld:lhgdn |
| lhgdn:association:58445 | lhgdn:geneRifSource | genetic polymorphisms of NAT1 and NAT2 have no independent effect on breast cancer risk, but they modulate breast cancer risk in the presence of GSTM1 and GSTT1 null genotypes. | lld:lhgdn |
| lhgdn:association:58509 | lhgdn:geneRifSource | genetic polymorphisms of NAT1 and NAT2 have no independent effect on breast cancer risk, but they modulate breast cancer risk in the presence of GSTM1 and GSTT1 null genotypes. | lld:lhgdn |
| lhgdn:association:63117 | lhgdn:geneRifSource | genetic polymorphisms of NAT1 and NAT2 have no independent effect on breast cancer risk, but they modulate breast cancer risk in the presence of GSTM1 and GSTT1 null genotypes. | lld:lhgdn |
| lhgdn:association:63119 | lhgdn:geneRifSource | genetic polymorphisms of NAT1 and NAT2 have no independent effect on breast cancer risk, but they modulate breast cancer risk in the presence of GSTM1 and GSTT1 null genotypes. | lld:lhgdn |
| lhgdn:association:63097 | lhgdn:geneRifSource | although there is little overall association between NAT genotypes and risk of developing systemic lupus erythematosus, the interaction between NAT1 and NAT2 and specific exposures such as hair dyes may be important. | lld:lhgdn |
| lhgdn:association:63124 | lhgdn:geneRifSource | The genotype for the NAT1 C1095A polymorphism does not appear to be an independent risk factor for spina bifida. | lld:lhgdn |
| lhgdn:association:63116 | lhgdn:geneRifSource | NAT1 variants that reduce or abolish enzyme activity appear to protect against spina bifida, and to exert their influence via both the maternal and the offspring genotypes. | lld:lhgdn |
| lhgdn:association:63098 | lhgdn:geneRifSource | Evidence that NAT1 and NAT2 genotypes are associated with Non-Hodgkin Lymphoma risk. | lld:lhgdn |
| lhgdn:association:63108 | lhgdn:geneRifSource | Identification of NAT1 residues that play a critical role in substrate binding reveals why human NAT1 acetylates sunscreen additive p-aminobenzoic acid and tobacco smoke carcinogen 4-aminobiphenyl but not arylamines linked to bladder cancer. | lld:lhgdn |
| lhgdn:association:55119 | lhgdn:geneRifSource | Genetic variation may affect the degree of association between pre-1980 hair dye use and the risk of non-Hodgkin lymphoma. | lld:lhgdn |
| lhgdn:association:63103 | lhgdn:geneRifSource | Genetic variation may affect the degree of association between pre-1980 hair dye use and the risk of non-Hodgkin lymphoma. | lld:lhgdn |
| lhgdn:association:63109 | lhgdn:geneRifSource | The effect of tamoxifen on NAT1 activity in a breast tumor cell line was studied. | lld:lhgdn |
| lhgdn:association:63106 | lhgdn:geneRifSource | NAT1 is significantly overexpressed in estrogen receptor-positive cancers; increasing evidence supports a biological role for NAT1 in breast cancer progression. | lld:lhgdn |
| lhgdn:association:63096 | lhgdn:geneRifSource | findings indicate an association between inflammation and suppression of NAT1 in cholangiocarcinoma cells, which perhaps contributes to chemical-mediated toxicity and carcinogenesis. | lld:lhgdn |
| lhgdn:association:63107 | lhgdn:geneRifSource | findings indicate an association between inflammation and suppression of NAT1 in cholangiocarcinoma cells, which perhaps contributes to chemical-mediated toxicity and carcinogenesis. | lld:lhgdn |
| lhgdn:association:14362 | lhgdn:geneRifSource | The aim of the study was to investigate NAT1, NAT2, GSTM1, GSTT1, GSTP1, SULT1A1, XRCC1, XRCC3 and XPD genetic polymorphisms, coffee consumption and risk of bladder cancer (BC) through a hospital-based case-control study. | lld:lhgdn |
| lhgdn:association:21019 | lhgdn:geneRifSource | The aim of the study was to investigate NAT1, NAT2, GSTM1, GSTT1, GSTP1, SULT1A1, XRCC1, XRCC3 and XPD genetic polymorphisms, coffee consumption and risk of bladder cancer (BC) through a hospital-based case-control study. | lld:lhgdn |
| lhgdn:association:21080 | lhgdn:geneRifSource | The aim of the study was to investigate NAT1, NAT2, GSTM1, GSTT1, GSTP1, SULT1A1, XRCC1, XRCC3 and XPD genetic polymorphisms, coffee consumption and risk of bladder cancer (BC) through a hospital-based case-control study. | lld:lhgdn |
| lhgdn:association:55136 | lhgdn:geneRifSource | The aim of the study was to investigate NAT1, NAT2, GSTM1, GSTT1, GSTP1, SULT1A1, XRCC1, XRCC3 and XPD genetic polymorphisms, coffee consumption and risk of bladder cancer (BC) through a hospital-based case-control study. | lld:lhgdn |
| lhgdn:association:57788 | lhgdn:geneRifSource | The aim of the study was to investigate NAT1, NAT2, GSTM1, GSTT1, GSTP1, SULT1A1, XRCC1, XRCC3 and XPD genetic polymorphisms, coffee consumption and risk of bladder cancer (BC) through a hospital-based case-control study. | lld:lhgdn |
| lhgdn:association:57948 | lhgdn:geneRifSource | The aim of the study was to investigate NAT1, NAT2, GSTM1, GSTT1, GSTP1, SULT1A1, XRCC1, XRCC3 and XPD genetic polymorphisms, coffee consumption and risk of bladder cancer (BC) through a hospital-based case-control study. | lld:lhgdn |
| lhgdn:association:58386 | lhgdn:geneRifSource | The aim of the study was to investigate NAT1, NAT2, GSTM1, GSTT1, GSTP1, SULT1A1, XRCC1, XRCC3 and XPD genetic polymorphisms, coffee consumption and risk of bladder cancer (BC) through a hospital-based case-control study. | lld:lhgdn |
| lhgdn:association:63120 | lhgdn:geneRifSource | The aim of the study was to investigate NAT1, NAT2, GSTM1, GSTT1, GSTP1, SULT1A1, XRCC1, XRCC3 and XPD genetic polymorphisms, coffee consumption and risk of bladder cancer (BC) through a hospital-based case-control study. | lld:lhgdn |
| lhgdn:association:63110 | lhgdn:geneRifSource | The present study does not support a relevant impact of the NAT1 genotype on colorectal cancer risk development in the study area. | lld:lhgdn |
| lhgdn:association:55145 | lhgdn:geneRifSource | Polymorphism of the N-acetyltransferase 2 gene as a susceptibility risk factor for antituberculosis drug-induced hepatitis. | lld:lhgdn |
| lhgdn:association:55181 | lhgdn:geneRifSource | The combined effect of N-acetyltransferase 2 (NAT2) slow genotype and exposure to smoking is observed during the development of laryngeal cancer. | lld:lhgdn |
| lhgdn:association:55114 | lhgdn:geneRifSource | NAT2 slow acetylation genotype may be a risk factor of individual susceptibility to rheumatoid arthritis. | lld:lhgdn |
| lhgdn:association:55141 | lhgdn:geneRifSource | Women with the GSTT1 null genotype were found to have a significant 3.15-fold increased risk of breast cancer (95% CI = 1.7-5.8), while GSTM1 and NAT2 genotypes were not associated with breast cancer risk. | lld:lhgdn |
| lhgdn:association:55153 | lhgdn:geneRifSource | Women with the GSTT1 null genotype were found to have a significant 3.15-fold increased risk of breast cancer (95% CI = 1.7-5.8), while GSTM1 and NAT2 genotypes were not associated with breast cancer risk. | lld:lhgdn |
| lhgdn:association:57730 | lhgdn:geneRifSource | Women with the GSTT1 null genotype were found to have a significant 3.15-fold increased risk of breast cancer (95% CI = 1.7-5.8), while GSTM1 and NAT2 genotypes were not associated with breast cancer risk. | lld:lhgdn |
| lhgdn:association:57740 | lhgdn:geneRifSource | Women with the GSTT1 null genotype were found to have a significant 3.15-fold increased risk of breast cancer (95% CI = 1.7-5.8), while GSTM1 and NAT2 genotypes were not associated with breast cancer risk. | lld:lhgdn |
| lhgdn:association:58345 | lhgdn:geneRifSource | Women with the GSTT1 null genotype were found to have a significant 3.15-fold increased risk of breast cancer (95% CI = 1.7-5.8), while GSTM1 and NAT2 genotypes were not associated with breast cancer risk. | lld:lhgdn |
| lhgdn:association:58450 | lhgdn:geneRifSource | Women with the GSTT1 null genotype were found to have a significant 3.15-fold increased risk of breast cancer (95% CI = 1.7-5.8), while GSTM1 and NAT2 genotypes were not associated with breast cancer risk. | lld:lhgdn |
| lhgdn:association:55179 | lhgdn:geneRifSource | A slow acetylator genotype of this enzyme is associated with an increased risk of advanced cervical cancer. | lld:lhgdn |
| lhgdn:association:55182 | lhgdn:geneRifSource | NAT2 slow acetylator genotype plays an important role in determining the risk of developing prostate cancer in Japanese men and is also associated with more clinically advanced and pathologically aggressive disease. | lld:lhgdn |
| lhgdn:association:55155 | lhgdn:geneRifSource | The NAT2 acetylator genotype may modify esophageal cancer risk in humans from exposure to barbecued/grilled meat. | lld:lhgdn |
| lhgdn:association:55140 | lhgdn:geneRifSource | NAT2 slow acetylation and GSTM1 null genotypes may increase postmenopausal breast cancer risk in long-term smoking women. | lld:lhgdn |
| lhgdn:association:14367 | lhgdn:geneRifSource | We conclude that smoking increases risk of colorectal adenomas and that SULT1A1 and NAT2 only modestly modify this association. | lld:lhgdn |
| lhgdn:association:55165 | lhgdn:geneRifSource | We conclude that smoking increases risk of colorectal adenomas and that SULT1A1 and NAT2 only modestly modify this association. | lld:lhgdn |
| lhgdn:association:55167 | lhgdn:geneRifSource | Cigarette smoking is associated with increased risk of breast cancer in women with the NAT2 slow acetylator genotype. | lld:lhgdn |
| lhgdn:association:55160 | lhgdn:geneRifSource | Only NAT2*14A fast type was associated with increased risk in patients with colorectal carcinoma (OR = 3.03; 95% CI, 1.56-5.86), when a high protein diet was considered, NAT2*7A/B fast genotype was also found to be associated with an increased risk. | lld:lhgdn |
| lhgdn:association:55158 | lhgdn:geneRifSource | Risks for colorectal cancer are significantly associated with the genetic polymorphisms of GSTT1 deletion, NAT2-rapid acetylator phenotype and genotye and NAT2-rapid acetylator phenotype. | lld:lhgdn |
| lhgdn:association:57745 | lhgdn:geneRifSource | Risks for colorectal cancer are significantly associated with the genetic polymorphisms of GSTT1 deletion, NAT2-rapid acetylator phenotype and genotye and NAT2-rapid acetylator phenotype. | lld:lhgdn |
| lhgdn:association:55131 | lhgdn:geneRifSource | Risk of colorectal cancer decreased with the NAT2 slow phenotype, and the use of white meat or its drippings. | lld:lhgdn |
| lhgdn:association:55123 | lhgdn:geneRifSource | There is a possible relationship between the NAT2 polymorphisms and colorectal cancer in Hebei Han Chinese. | lld:lhgdn |
| lhgdn:association:55183 | lhgdn:geneRifSource | NAT2 gene is one of the determinants for Crohn disease in Japanese patients. | lld:lhgdn |
| lhgdn:association:55162 | lhgdn:geneRifSource | The fast NAT acetylator status, which may result in altered NAT detoxifaction capacity, is associated with preeclampsia. | lld:lhgdn |
| lhgdn:association:55188 | lhgdn:geneRifSource | Polymorphism of NAT2 is associated with the risk of atopic dermatitis. | lld:lhgdn |
| lhgdn:association:55161 | lhgdn:geneRifSource | NAT2 genotype might play a role of effect modifier in bladder cancer carcinogenesis. | lld:lhgdn |
| lhgdn:association:55118 | lhgdn:geneRifSource | No evidence of an overall association of NAT2 gene polymorphisms to either colon or lung cancer risk. | lld:lhgdn |
| lhgdn:association:55133 | lhgdn:geneRifSource | These data do not support the hypothesis that the NAT2 acetylatorship acts as a modifying factor on the age of onset in sporadic and familial, microsatellite stable colorectal cancer. | lld:lhgdn |
| lhgdn:association:55117 | lhgdn:geneRifSource | These results suggest that NAT2 slow acetylator phenotype influences the susceptibility of gallbladder cancer. | lld:lhgdn |
| lhgdn:association:55128 | lhgdn:geneRifSource | patients with the NAT2 fast acetylator genotype were more prone to colorectal cancer and reflected the possibility that exposure to heterocyclic amines may contribute to colorectal cancer development in Taiwan, especially in Taiwanese females. | lld:lhgdn |
| lhgdn:association:55147 | lhgdn:geneRifSource | Paclitaxel inhibits NAT2 activity and gene expression in stomach neoplasms. | lld:lhgdn |
| lhgdn:association:55148 | lhgdn:geneRifSource | NAT2 genotypes and phenotypes are not associated with gastric cancer risk predisposition. | lld:lhgdn |
| lhgdn:association:55146 | lhgdn:geneRifSource | The researchers found an association between a NAT2 gene substitution at T341C and an increased risk of head and neck cancer in Tunisia. | lld:lhgdn |
| lhgdn:association:55187 | lhgdn:geneRifSource | Opposite effects of NAT2 gene polymorphisms on the risk of lung cancer are possible. | lld:lhgdn |
| lhgdn:association:55127 | lhgdn:geneRifSource | NAT2 gene polymorphisms may be associated with genetic susceptibility to pancreatic cancer. | lld:lhgdn |
| lhgdn:association:55152 | lhgdn:geneRifSource | The analysis of NAT2 polymorphism does not seem to be useful in predicting the risk of PD with dementia or AD. | lld:lhgdn |
| lhgdn:association:55134 | lhgdn:geneRifSource | The combination of NAT2 rapid plus other genotypes is associated with susceptibility to colorectal cancer in Japanese never-smokers. | lld:lhgdn |
| lhgdn:association:55185 | lhgdn:geneRifSource | The presence of NAT2*7 allele might be a potential risk factor for the development of brain tumors in Taiwan. | lld:lhgdn |
| lhgdn:association:55111 | lhgdn:geneRifSource | Lack of the NAT2*4 haplotype is strongly linked to adverse effects with sulfosalazine therapy in Japanese patients with rheumatoid arthritis. | lld:lhgdn |
| lhgdn:association:55178 | lhgdn:geneRifSource | The present study indicates that bladder cancer risk due to exposure to aromatic amines is modulated by the polymorphic xenobiotic-metabolizing enzyme NAT2. | lld:lhgdn |
| lhgdn:association:55189 | lhgdn:geneRifSource | polymorphic variants of genes GSTT1, GSTM1, NAT2 and MTRR can modulate the risk of childhood acute leukemia, residents of European part of Russia. | lld:lhgdn |
| lhgdn:association:57765 | lhgdn:geneRifSource | polymorphic variants of genes GSTT1, GSTM1, NAT2 and MTRR can modulate the risk of childhood acute leukemia, residents of European part of Russia. | lld:lhgdn |
| lhgdn:association:58475 | lhgdn:geneRifSource | polymorphic variants of genes GSTT1, GSTM1, NAT2 and MTRR can modulate the risk of childhood acute leukemia, residents of European part of Russia. | lld:lhgdn |
| lhgdn:association:59110 | lhgdn:geneRifSource | polymorphic variants of genes GSTT1, GSTM1, NAT2 and MTRR can modulate the risk of childhood acute leukemia, residents of European part of Russia. | lld:lhgdn |
| lhgdn:association:55144 | lhgdn:geneRifSource | These results implicate fast NAT2 acetylation as a risk factor for oral cancer. | lld:lhgdn |
| lhgdn:association:31420 | lhgdn:geneRifSource | The results indicate that phenotypic differences in NAT2 alone or in combination with CYP1A2 might help explain the higher incidence rates of transitional cell bladder cancer in white cigarette smokers compared with black smokers. | lld:lhgdn |
| lhgdn:association:55129 | lhgdn:geneRifSource | The results indicate that phenotypic differences in NAT2 alone or in combination with CYP1A2 might help explain the higher incidence rates of transitional cell bladder cancer in white cigarette smokers compared with black smokers. | lld:lhgdn |
| lhgdn:association:55176 | lhgdn:geneRifSource | There was no association with the NAT2 gene, genital talc use and risk of ovarian cancer. | lld:lhgdn |
| lhgdn:association:55095 | lhgdn:geneRifSource | Multivariate analysis showed that ACT mRNA level, but not STC2 mRNA level, in HR-positive patients, was a significant prognostic factor (P = 0.042), which was independent of tumor size and lymph node metastases. | lld:lhgdn |
| lhgdn:association:55096 | lhgdn:geneRifSource | Multivariate analysis showed that ACT mRNA level, but not STC2 mRNA level, in HR-positive patients, was a significant prognostic factor (P = 0.042), which was independent of tumor size and lymph node metastases. | lld:lhgdn |