GENERIC protein serine/threonine kinase activity

Statements in which the resource exists as a subject.
Predicate	Object
rdf:type	skos:Concept
skos:definition	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]
skos:inScheme	lld:geneontology
skos:prefLabel	protein serine/threonine kinase activity
skos:altLabel	protein serine-threonine kinase activity, serine(threonine) protein kinase activity, serine/threonine protein kinase activity
skos:notation	EC:2.7.11, Reactome:REACT_100117 "Phosphorylation of eIF2-alpha by PERK, Xenopus tropicalis", Reactome:REACT_100192 "AKT phosphorylates IKKalpha, Canis familiaris", Reactome:REACT_100209 "ERK1/2/5 activate RSK1/2/3, Canis familiaris", Reactome:REACT_100224 "Activation of cytosolic AMPK by phosphorylation, Bos taurus", Reactome:REACT_100446 "Activation of cytosolic AMPK by phosphorylation, Rattus norvegicus", Reactome:REACT_100588 "ERK5 activates the transcription factor MEF2, Xenopus tropicalis", Reactome:REACT_100590 "AKT phosphorylates IKKalpha, Xenopus tropicalis", Reactome:REACT_100784 "AKT phosphorylates IKKalpha, Rattus norvegicus", Reactome:REACT_100870 "Phospho-IKK Complex phosphorylates IkB within the IkB:NFkB Complex, Bos taurus", Reactome:REACT_100918 "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding, Mus musculus", Reactome:REACT_100989 "Autophosphorylation of IRE1 dimer, Saccharomyces cerevisiae", Reactome:REACT_101264 "Phosphorylated MAPKs phosphorylate ATF-2, Sus scrofa", Reactome:REACT_101280 "Activation of claspin, Xenopus tropicalis", Reactome:REACT_101291 "Phospho-IKK Complex phosphorylates IkB within the IkB:NFkB Complex, Danio rerio", Reactome:REACT_101497 "Activation of claspin, Bos taurus", Reactome:REACT_101896 "ERK1/2 phosphorylates MSK1, Canis familiaris", Reactome:REACT_101920 "Inactivation of MEK1 by p34cdc2, Drosophila melanogaster", Reactome:REACT_101930 "Inactivation of MEK1 by p34cdc2, Caenorhabditis elegans", Reactome:REACT_102053 "MEK1 phosphorylates ERK-1, Saccharomyces cerevisiae", Reactome:REACT_102074 "AKT phosphorylates caspase-9, Mus musculus", Reactome:REACT_102078 "Phosphorylation of Cdc25C at Ser 216 by Chk1, Canis familiaris", Reactome:REACT_102096 "Activation of cytosolic AMPK by phosphorylation, Gallus gallus", Reactome:REACT_102133 "Phosphorylated MAPKs phosphorylate ATF-2, Mus musculus", Reactome:REACT_102370 "AKT can phosphorylate NUR77, Mus musculus", Reactome:REACT_102455 "Active p38 MAPK phosphorylates MAPKAPK2 or 3, Canis familiaris", Reactome:REACT_102500 "AKT can phosphorylate RSK, Rattus norvegicus", Reactome:REACT_102718 "Active p38 MAPK phosphorylates MAPKAPK2 or 3, Bos taurus", Reactome:REACT_102778 "ERK1/2/5 activate RSK1/2/3, Gallus gallus", Reactome:REACT_102791 "Activation of NF-kB complex, Xenopus tropicalis", Reactome:REACT_102943 "Phosphorylated MAPKs phosphorylate ATF-2, Rattus norvegicus", Reactome:REACT_102975 "LIM kinase phosphorylation by ROCK, Danio rerio", Reactome:REACT_103109 "Phosphorylation of CRMPs by Cdk5, Xenopus tropicalis", Reactome:REACT_103162 "Myosin regulatory light chain phosphorylation by ROCK, Xenopus tropicalis", Reactome:REACT_103217 "Phosphorylation of PKC theta, Xenopus tropicalis", Reactome:REACT_103304 "Phosphorylation of FANCI by ATM/ATR, Danio rerio", Reactome:REACT_103449 "PDK1 phosphorylates AKT at T308, Caenorhabditis elegans", Reactome:REACT_103541 "Activated TAK1 mediates phosphorylation of the IKK Complex, Sus scrofa", Reactome:REACT_103596 "MEK1 phosphorylates ERK-1, Bos taurus", Reactome:REACT_103658 "Phosphorylation of MARCKS by Protein kinase C, alpha type, Bos taurus", Reactome:REACT_103882 "Phosphorylation of CRY and PER Proteins, Sus scrofa", Reactome:REACT_104102 "Active p38 MAPK phosphorylates MAPKAPK2 or 3, Mus musculus", Reactome:REACT_104121 "LIM kinase phosphorylation by ROCK, Drosophila melanogaster", Reactome:REACT_104145 "PDK1 phosphorylates AKT at T308, Canis familiaris", Reactome:REACT_104284 "Active p38 MAPK phosphorylates MAPKAPK2 or 3, Xenopus tropicalis", Reactome:REACT_104288 "Phosphorylation of FANCI by ATM/ATR, Drosophila melanogaster", Reactome:REACT_104416 "ERK1/2 activates ELK1, Canis familiaris", Reactome:REACT_104521 "MEK1 phosphorylates ERK-1, Mus musculus", Reactome:REACT_104525 "Phosphorylation of PKC theta, Taeniopygia guttata", Reactome:REACT_104547 "Recruitment and activation of Chk1, Gallus gallus", Reactome:REACT_104549 "Phosphorylation of Bcl10, Gallus gallus", Reactome:REACT_104564 "AKT phosphorylates caspase-9, Bos taurus", Reactome:REACT_104874 "Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9, Mus musculus", Reactome:REACT_104906 "Myosin regulatory light chain phosphorylation by ROCK, Mus musculus", Reactome:REACT_104932 "AKT can phosphorylate NUR77, Canis familiaris", Reactome:REACT_104985 "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP, Rattus norvegicus", Reactome:REACT_105016 "p38MAPK phosphorylates MSK1, Saccharomyces cerevisiae", Reactome:REACT_105038 "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP, Sus scrofa", Reactome:REACT_105077 "Phosphorylation of MARCKS by Protein kinase C, alpha type, Mus musculus", Reactome:REACT_105298 "Activation of IKK complex, Danio rerio", Reactome:REACT_105447 "Phosphorylation of CARMA1, Xenopus tropicalis", Reactome:REACT_105470 "Phosphorylation of FANCD2 by ATR/ATM, Gallus gallus", Reactome:REACT_105502 "AKT interacts and phosphorylates Cot, Taeniopygia guttata", Reactome:REACT_105534 "p38MAPK phosphorylates MSK1, Drosophila melanogaster", Reactome:REACT_105602 "MSK1 activates CREB, Sus scrofa", Reactome:REACT_105625 "AKT can phosphorylate forkhead box transcription factors, Canis familiaris", Reactome:REACT_105894 "PKA phosphorylates CREB, Canis familiaris", Reactome:REACT_106015 "Phosphorylation of Bcl10, Bos taurus", Reactome:REACT_106033 "ERK1/2/5 activate RSK1/2/3, Danio rerio", Reactome:REACT_106141 "AKT phosphorylates IKKalpha, Bos taurus", Reactome:REACT_106200 "PKA phosphorylates CREB, Danio rerio", Reactome:REACT_106255 "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP, Mus musculus", Reactome:REACT_106263 "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9, Bos taurus", Reactome:REACT_106338 "ERK1/2/5 activate RSK1/2/3, Xenopus tropicalis", Reactome:REACT_106350 "Phosphorylation of CRY and PER Proteins, Xenopus tropicalis", Reactome:REACT_106414 "CERT + ATP => monophospho-CERT + ADP, Taeniopygia guttata", Reactome:REACT_106418 "IRAK is activated, Canis familiaris", Reactome:REACT_106434 "Activation of claspin, Canis familiaris", Reactome:REACT_106501 "Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9, Canis familiaris", Reactome:REACT_106556 "Activation of TAK1-TAB2 complex, Xenopus tropicalis", Reactome:REACT_106557 "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9, Taeniopygia guttata", Reactome:REACT_106566 "Phosphorylation of CARMA1, Rattus norvegicus", Reactome:REACT_106589 "MEK1 phosphorylates ERK-1, Schizosaccharomyces pombe", Reactome:REACT_106643 "Autophosphorylation of IRE1 dimer, Danio rerio", Reactome:REACT_106685 "Myosin regulatory light chain phosphorylation by ROCK, Rattus norvegicus", Reactome:REACT_106700 "AKT phosphorylates PRAS40, Rattus norvegicus", Reactome:REACT_106730 "Phosphorylation of Cdc25C at Ser 216 by Chk1, Mus musculus", Reactome:REACT_106732 "Recruitment and activation of Chk1, Canis familiaris", Reactome:REACT_106789 "Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9, Rattus norvegicus", Reactome:REACT_106853 "Phosphorylation of MARCKS by Protein kinase C, alpha type, Rattus norvegicus", Reactome:REACT_106862 "Phosphorylation of MARCKS by Protein kinase C, alpha type, Xenopus tropicalis", Reactome:REACT_106985 "Phosphorylation of LIMK-1 by PAK, Danio rerio", Reactome:REACT_107087 "IKKbeta is activated, Bos taurus"

skos:definition

"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]

skos:prefLabel

protein serine/threonine kinase activity

skos:notation

EC:2.7.11, Reactome:REACT_100117 "Phosphorylation of eIF2-alpha by PERK, Xenopus tropicalis", Reactome:REACT_100192 "AKT phosphorylates IKKalpha, Canis familiaris", Reactome:REACT_100209 "ERK1/2/5 activate RSK1/2/3, Canis familiaris", Reactome:REACT_100224 "Activation of cytosolic AMPK by phosphorylation, Bos taurus", Reactome:REACT_100446 "Activation of cytosolic AMPK by phosphorylation, Rattus norvegicus", Reactome:REACT_100588 "ERK5 activates the transcription factor MEF2, Xenopus tropicalis", Reactome:REACT_100590 "AKT phosphorylates IKKalpha, Xenopus tropicalis", Reactome:REACT_100784 "AKT phosphorylates IKKalpha, Rattus norvegicus", Reactome:REACT_100870 "Phospho-IKK Complex phosphorylates IkB within the IkB:NFkB Complex, Bos taurus", Reactome:REACT_100918 "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding, Mus musculus", Reactome:REACT_100989 "Autophosphorylation of IRE1 dimer, Saccharomyces cerevisiae", Reactome:REACT_101264 "Phosphorylated MAPKs phosphorylate ATF-2, Sus scrofa", Reactome:REACT_101280 "Activation of claspin, Xenopus tropicalis", Reactome:REACT_101291 "Phospho-IKK Complex phosphorylates IkB within the IkB:NFkB Complex, Danio rerio", Reactome:REACT_101497 "Activation of claspin, Bos taurus", Reactome:REACT_101896 "ERK1/2 phosphorylates MSK1, Canis familiaris", Reactome:REACT_101920 "Inactivation of MEK1 by p34cdc2, Drosophila melanogaster", Reactome:REACT_101930 "Inactivation of MEK1 by p34cdc2, Caenorhabditis elegans", Reactome:REACT_102053 "MEK1 phosphorylates ERK-1, Saccharomyces cerevisiae", Reactome:REACT_102074 "AKT phosphorylates caspase-9, Mus musculus", Reactome:REACT_102078 "Phosphorylation of Cdc25C at Ser 216 by Chk1, Canis familiaris", Reactome:REACT_102096 "Activation of cytosolic AMPK by phosphorylation, Gallus gallus", Reactome:REACT_102133 "Phosphorylated MAPKs phosphorylate ATF-2, Mus musculus", Reactome:REACT_102370 "AKT can phosphorylate NUR77, Mus musculus", Reactome:REACT_102455 "Active p38 MAPK phosphorylates MAPKAPK2 or 3, Canis familiaris", Reactome:REACT_102500 "AKT can phosphorylate RSK, Rattus norvegicus", Reactome:REACT_102718 "Active p38 MAPK phosphorylates MAPKAPK2 or 3, Bos taurus", Reactome:REACT_102778 "ERK1/2/5 activate RSK1/2/3, Gallus gallus", Reactome:REACT_102791 "Activation of NF-kB complex, Xenopus tropicalis", Reactome:REACT_102943 "Phosphorylated MAPKs phosphorylate ATF-2, Rattus norvegicus", Reactome:REACT_102975 "LIM kinase phosphorylation by ROCK, Danio rerio", Reactome:REACT_103109 "Phosphorylation of CRMPs by Cdk5, Xenopus tropicalis", Reactome:REACT_103162 "Myosin regulatory light chain phosphorylation by ROCK, Xenopus tropicalis", Reactome:REACT_103217 "Phosphorylation of PKC theta, Xenopus tropicalis", Reactome:REACT_103304 "Phosphorylation of FANCI by ATM/ATR, Danio rerio", Reactome:REACT_103449 "PDK1 phosphorylates AKT at T308, Caenorhabditis elegans", Reactome:REACT_103541 "Activated TAK1 mediates phosphorylation of the IKK Complex, Sus scrofa", Reactome:REACT_103596 "MEK1 phosphorylates ERK-1, Bos taurus", Reactome:REACT_103658 "Phosphorylation of MARCKS by Protein kinase C, alpha type, Bos taurus", Reactome:REACT_103882 "Phosphorylation of CRY and PER Proteins, Sus scrofa", Reactome:REACT_104102 "Active p38 MAPK phosphorylates MAPKAPK2 or 3, Mus musculus", Reactome:REACT_104121 "LIM kinase phosphorylation by ROCK, Drosophila melanogaster", Reactome:REACT_104145 "PDK1 phosphorylates AKT at T308, Canis familiaris", Reactome:REACT_104284 "Active p38 MAPK phosphorylates MAPKAPK2 or 3, Xenopus tropicalis", Reactome:REACT_104288 "Phosphorylation of FANCI by ATM/ATR, Drosophila melanogaster", Reactome:REACT_104416 "ERK1/2 activates ELK1, Canis familiaris", Reactome:REACT_104521 "MEK1 phosphorylates ERK-1, Mus musculus", Reactome:REACT_104525 "Phosphorylation of PKC theta, Taeniopygia guttata", Reactome:REACT_104547 "Recruitment and activation of Chk1, Gallus gallus", Reactome:REACT_104549 "Phosphorylation of Bcl10, Gallus gallus", Reactome:REACT_104564 "AKT phosphorylates caspase-9, Bos taurus", Reactome:REACT_104874 "Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9, Mus musculus", Reactome:REACT_104906 "Myosin regulatory light chain phosphorylation by ROCK, Mus musculus", Reactome:REACT_104932 "AKT can phosphorylate NUR77, Canis familiaris", Reactome:REACT_104985 "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP, Rattus norvegicus", Reactome:REACT_105016 "p38MAPK phosphorylates MSK1, Saccharomyces cerevisiae", Reactome:REACT_105038 "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP, Sus scrofa", Reactome:REACT_105077 "Phosphorylation of MARCKS by Protein kinase C, alpha type, Mus musculus", Reactome:REACT_105298 "Activation of IKK complex, Danio rerio", Reactome:REACT_105447 "Phosphorylation of CARMA1, Xenopus tropicalis", Reactome:REACT_105470 "Phosphorylation of FANCD2 by ATR/ATM, Gallus gallus", Reactome:REACT_105502 "AKT interacts and phosphorylates Cot, Taeniopygia guttata", Reactome:REACT_105534 "p38MAPK phosphorylates MSK1, Drosophila melanogaster", Reactome:REACT_105602 "MSK1 activates CREB, Sus scrofa", Reactome:REACT_105625 "AKT can phosphorylate forkhead box transcription factors, Canis familiaris", Reactome:REACT_105894 "PKA phosphorylates CREB, Canis familiaris", Reactome:REACT_106015 "Phosphorylation of Bcl10, Bos taurus", Reactome:REACT_106033 "ERK1/2/5 activate RSK1/2/3, Danio rerio", Reactome:REACT_106141 "AKT phosphorylates IKKalpha, Bos taurus", Reactome:REACT_106200 "PKA phosphorylates CREB, Danio rerio", Reactome:REACT_106255 "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP, Mus musculus", Reactome:REACT_106263 "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9, Bos taurus", Reactome:REACT_106338 "ERK1/2/5 activate RSK1/2/3, Xenopus tropicalis", Reactome:REACT_106350 "Phosphorylation of CRY and PER Proteins, Xenopus tropicalis", Reactome:REACT_106414 "CERT + ATP => monophospho-CERT + ADP, Taeniopygia guttata", Reactome:REACT_106418 "IRAK is activated, Canis familiaris", Reactome:REACT_106434 "Activation of claspin, Canis familiaris", Reactome:REACT_106501 "Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9, Canis familiaris", Reactome:REACT_106556 "Activation of TAK1-TAB2 complex, Xenopus tropicalis", Reactome:REACT_106557 "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9, Taeniopygia guttata", Reactome:REACT_106566 "Phosphorylation of CARMA1, Rattus norvegicus", Reactome:REACT_106589 "MEK1 phosphorylates ERK-1, Schizosaccharomyces pombe", Reactome:REACT_106643 "Autophosphorylation of IRE1 dimer, Danio rerio", Reactome:REACT_106685 "Myosin regulatory light chain phosphorylation by ROCK, Rattus norvegicus", Reactome:REACT_106700 "AKT phosphorylates PRAS40, Rattus norvegicus", Reactome:REACT_106730 "Phosphorylation of Cdc25C at Ser 216 by Chk1, Mus musculus", Reactome:REACT_106732 "Recruitment and activation of Chk1, Canis familiaris", Reactome:REACT_106789 "Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9, Rattus norvegicus", Reactome:REACT_106853 "Phosphorylation of MARCKS by Protein kinase C, alpha type, Rattus norvegicus", Reactome:REACT_106862 "Phosphorylation of MARCKS by Protein kinase C, alpha type, Xenopus tropicalis", Reactome:REACT_106985 "Phosphorylation of LIMK-1 by PAK, Danio rerio", Reactome:REACT_107087 "IKKbeta is activated, Bos taurus"