Source:http://linkedlifedata.com/resource/geneontology/id/GO:0004498
| Predicate | Object |
|---|---|
| rdf:type | |
| skos:definition |
"Catalysis of the reaction: calcidiol + H(+) + NADPH + O(2) = calcitriol + H(2)O + NADP(+)." [EC:1.14.13.13, RHEA:20576]
|
| skos:inScheme | |
| skos:prefLabel |
calcidiol 1-monooxygenase activity
|
| skos:altLabel |
25-OHD-1 alpha-hydroxylase activity,
25-hydroxy D3-1alpha-hydroxylase activity,
25-hydroxy vitamin D3 1-alpha-hydroxylase activity,
25-hydroxycholecalciferol 1-hydroxylase activity,
25-hydroxycholecalciferol 1-monooxygenase activity,
25-hydroxycholecalciferol 1alpha-hydroxylase activity,
25-hydroxycholecalciferol-1-hydroxylase activity,
25-hydroxyvitamin D-1 alpha hydroxylase activity,
25-hydroxyvitamin D3 1alpha-hydroxylase activity,
calcidiol,NADPH:oxygen oxidoreductase (1-hydroxylating)
|
| skos:notation |
EC:1.14.13.13,
KEGG:R03610,
MetaCyc:CALCIDIOL-1-MONOOXYGENASE-RXN,
RHEA:20576,
Reactome:REACT_102929 "Further hydroxylation of calcidiol in kidney to form calcitriol, Danio rerio",
Reactome:REACT_106826 "Further hydroxylation of calcidiol in kidney to form calcitriol, Drosophila melanogaster",
Reactome:REACT_110331 "Further hydroxylation of calcidiol in kidney to form calcitriol, Canis familiaris",
Reactome:REACT_13628 "Further hydroxylation of calcidiol in kidney to form calcitriol, Homo sapiens",
Reactome:REACT_83168 "Further hydroxylation of calcidiol in kidney to form calcitriol, Xenopus tropicalis",
Reactome:REACT_84663 "Further hydroxylation of calcidiol in kidney to form calcitriol, Bos taurus",
Reactome:REACT_93300 "Further hydroxylation of calcidiol in kidney to form calcitriol, Mus musculus"
|
| skos:broader | |
| skos:relatedSynonym |
1-hydroxylase-25-hydroxyvitamin D3 activity
|
| skos:narrowSynonym |
cytochrome P450 CYP27B
|