Source:http://linkedlifedata.com/resource/entrezgene/interaction/5604-155871
| Predicate | Object |
|---|---|
| rdf:type | |
| entrezgene:pubmed |
pubmed-article:10509564,
pubmed-article:10780709,
pubmed-article:10799874,
pubmed-article:10982368,
pubmed-article:11044099,
pubmed-article:11260070,
pubmed-article:11409852,
pubmed-article:11579140,
pubmed-article:12167619,
pubmed-article:12482669,
pubmed-article:18569454,
pubmed-article:20019835,
pubmed-article:20433920,
pubmed-article:9223324,
pubmed-article:9325171,
pubmed-article:9558095,
pubmed-article:9621077
|
| entrezgene:interactant | |
| entrezgene:geneRifText |
HIV-1 Tat activates mitogen-activated protein kinases ERK1 and ERK2 through the activation of MEK1 and MEK2, leading to induction of IL-8, IL-10, IP-10, iNOS, superoxide and TNF-alpha, as well as the activation of CREB and increased albumin permeability,
HIV-1 Tat in combination with KSHV kaposin A activates the MEK/ERK, STAT3, and PI3K/Akt signals in NIH3T3 cells,
HIV-1 Tat-peptide(48-60) inhibits AGC-family kinases (PKB, SGK1, S6K1, MSK1), CAMK-family kinases (CAMK1 and MELK) and a STE family kinase (MKK1),
Tat and IFN-gamma synergistically induce the expression of CXCL10, which is inhibited by MEK1/2 inhibitor and the p38 mitogen-activated protein kinase (MAPK) inhibitor
|
| entrezgene:keyphrase |
inhibits,
modulates,
activates
|