Source:http://linkedlifedata.com/resource/entrezgene/interaction/3725-155871
| Predicate | Object |
|---|---|
| rdf:type | |
| entrezgene:pubmed |
pubmed-article:10509564,
pubmed-article:10644332,
pubmed-article:10799874,
pubmed-article:11254713,
pubmed-article:11260070,
pubmed-article:11448159,
pubmed-article:12485413,
pubmed-article:15258149,
pubmed-article:16690925,
pubmed-article:18097055,
pubmed-article:21034562,
pubmed-article:21607373,
pubmed-article:22077140,
pubmed-article:22450687,
pubmed-article:7690421,
pubmed-article:9129988,
pubmed-article:9223324,
pubmed-article:9621077,
pubmed-article:9670954
|
| entrezgene:interactant | |
| entrezgene:geneRifText |
Crosslinking experiments suggest a direct binding interaction between HIV-1 Tat and AP1 that is relatively inefficient and that correlates with the ability of AP1 to support Tat transactivation,
Extracellular HIV-1 Tat upregulates the expression of human beta-defensin 2 (hBD-2) via JNK/NF-KappaB/AP-1-dependent pathways in human B cells,
HIV-1 Tat activates c-jun (Activator Protein-1; AP-1) through the activation of JNK, an effect mediated through the activation of p56lck,
HIV-1 Tat expression in Jurkat T cells enhances cooperative NFAT/AP-1- but not AP-1-dependent transcription independent of its ability to transactivate the HIV-1 LTR,
HIV-1 Tat interacts with the cooperative rel/AP1 complex, downregulating its transactivation activity and leading to a decrease in IL-2 gene transcription,
HIV-1 Tat-induced expression of MCP-1 is partially mediated through the activation of c-jun (Activator Protein-1; AP-1) binding to, and transactivation of the MCP-1 promoter by Tat,
The CKLF-like MARVEL transmembrane domain-containing family 2 (CMTM2) blocks HIV-1 Tat-induced AP-1 and CREB activation, which leads to suppress HIV-1 provirus transcription,
Transcription factors NFAT and AP-1 (c-Jun/c-Fos) are required for HIV-1 Tat-induced upregulation of COX-2
|
| entrezgene:keyphrase |
downregulates,
requires,
binds,
activates,
enhances
|