Source:http://linkedlifedata.com/resource/entrezgene/interaction/3683-155971
| Predicate | Object |
|---|---|
| rdf:type | |
| entrezgene:pubmed |
pubmed-article:15183063,
pubmed-article:15222882,
pubmed-article:17078873,
pubmed-article:1757107,
pubmed-article:18264102,
pubmed-article:19211748,
pubmed-article:1967280,
pubmed-article:19721069,
pubmed-article:20890395,
pubmed-article:21284901,
pubmed-article:21850260,
pubmed-article:22190034,
pubmed-article:22908191,
pubmed-article:2543075,
pubmed-article:7904170,
pubmed-article:7917519,
pubmed-article:8450224,
pubmed-article:9263011,
pubmed-article:9341793
|
| entrezgene:interactant | |
| entrezgene:geneRifText |
Anti-CD18 monoclonal antibodies completely block cell fusion between HIV-1 infected U-937 cells and MT-4 T cells, indicating participation of CD18, or of the protein complex CD11a-c/CD18, in addition to CD4, in the infection and cytopathic effect of HIV-1,
Antibodies against cell surface molecules LFA-1, ICAM-1, HLA-DR, and CD28 inhibit the HIV-1 gp160-induced B cell differentiation response; gp160 also induces IL-6R and CD23 molecule expression on B cells,
Cells treated with monoclonal antibodies to ICAM-1 and LFA-1 adhesion molecules show an impaired release of IFN after HIV-1 gp120 stimulation, suggesting a crucial role of cell-to-cell interactions in the process leading to IFN production,
HIV-1 gp120 induces CD4 association with lymphocyte surface molecules CD3, CD11a, CD27, CD45RA, CD45RB, CD45RO, CD49d, CD38, CD26, CD59, CD95 and class I MHC molecules,
HIV-1 gp160 downregulates lymphocyte function-associated antigen-1 (LFA-1)-dependent adhesion between CD4+ T cells and B cells; this downregulation is shown to be p56lck-dependent,
HIV-1 gp160 is identified to have a physical interaction with integrin, alpha L (ITGAL) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses,
HIV-1 replication is delayed in LFA-1 negative T cells after Dendritic cell (DC)-mediated transmission; activation of LFA-1 is crucial for efficient DC-mediated HIV-1 transmission, suggesting an interaction between LFA-1 and HIV-1 gp120,
ICAM-1 promotes HIV-1 gp160-mediated syncytium formation, and the ICAM-1 contrareceptor LFA-1 attenuates the syncytium-inhibiting activity of virus-neutralizing monoclonal antibodies and soluble CD4,
Infectivity of an HIV-1 Matrix mutant that carries a suboptimal amount of HIV-1 gp120/41 is restored to a certain degree by the presence of ICAM-1 when infection is performed in cells expressing an activated form of its natural counter-ligand, LFA-1,
PI3-kinase activation induced by HIV-1 gp160 leads to downregulation of LFA-1-mediated T cell adhesion to B cells,
The gp120-integrin alpha4beta7 complex mediates LFA-1 activation on T cells and increases the efficiency of infection by promoting synapse formation,
The interaction of CD4+ T cells with HIV-1 gp120 on bilayers triggers LFA-1 activation and the LFA-1-ICAM-1 interaction rearrangement
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| entrezgene:keyphrase |
inhibits,
downregulates,
interacts with,
activates,
mediated by
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