Source:http://linkedlifedata.com/resource/entrezgene/hivinteraction/155871-6908
| Predicate | Object |
|---|---|
| rdf:type | |
| entrezgene:pubmed |
pubmed-article:10066804,
pubmed-article:11080476,
pubmed-article:15719058,
pubmed-article:7608968,
pubmed-article:7835343,
pubmed-article:7933101,
pubmed-article:8121496,
pubmed-article:8207805,
pubmed-article:8230415,
pubmed-article:8680883,
pubmed-article:8764009,
pubmed-article:8764062,
pubmed-article:9054383,
pubmed-article:9121429,
pubmed-article:9292011,
pubmed-article:9372921,
pubmed-article:9632719,
pubmed-article:9765201,
pubmed-article:9814863
|
| entrezgene:interactant | |
| entrezgene:geneRifText |
Binding of HIV-1 Tat to TBP has been mapped to the cysteine rich and core domains (amino acids 20-50) of Tat and the H1 alpha helical and S2 domains (amino acids 163-220) of TBP,
Binding of HIV-1 Tat to p300 induces a conformational change in the CBP/p300 complex such that it can acquire and bind better to basal transcription factors such as TBP, indicating Tat helps CBP/p300 recruit new partners to the transcription machinery,
Binding of HIV-1 Tat to the TBP subunit of TFIID stabilizes the interaction of TFIID with TFIIA,
HIV-1 Tat binds directly to the basal transcription factor TFIID through the TBP subunit of TFIID,
HIV-1 Tat competes for Dr1 interaction with TBP,
HIV-1 Tat directly interacts with TBP as demonstrated by Tat-affinity column purification,
HIV-1 Tat interacts with the RNA polymerase II holoenzyme complex that supports Tat-mediated transactivation of the HIV-1 LTR in vitro upon addition of TBP and TFIIB,
Inhibition of HIV-1 Tat by p53 is mediated through the Sp1 and TATA box of the HIV-1 LTR, suggesting p53 interferes with the interaction between Tat and TBP during LTR transactivation,
Interaction of TBP/TFIID with the HIV-1 LTR, and therefore presumably HIV-1 Tat, is primarily dependent on the LTR TATA element and may also be stabilized or regulated by flanking E box motifs and basic helix-loop-helix proteins such as AP-4 and E47,
Recruitment of TBP to the HIV-1 LTR promoter is a limiting step for HIV-1 Tat transactivation, however interaction of Tat with TBP/TFIID occurs after this recruitment,
TBP interacts with HIV-1 Tat as part of the HIV-1 transcription preinitiation complex (PIC) and is necessary for Tat association with the PIC,
TBP is required for HIV-1 Tat-mediated transactivation of the HIV-1 LTR promoter,
TBP synergizes with HIV-1 Tat during Tat-mediated transactivation of the HIV-1 LTR promoter
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| entrezgene:keyphrase |
interacts with,
requires,
binds,
recruits,
stabilizes,
synergizes with
|