Linked Life Data

155807-995

Source:http://linkedlifedata.com/resource/entrezgene/hivinteraction/155807-995

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PredicateObject
rdf:type
entrezgene:pubmed
entrezgene:interactant
entrezgene:geneRifText
A minimal domain between amino acids 334 and 379 of Cdc25c, upstream of its catalytic site, is sufficient to bind HIV-1 Vpr; mutation at residue E352 of Cdc25c greatly reduces binding of Vpr to Cdc25c, Binding of Cdc25c to HIV-1 Vpr is required for Vpr-mediated G2 arrest in HeLa cells, HIV-1 Vpr forms a triple complex with 14-3-3 eta and Cdc25C and thereby promotes cell cycle arrest at the G(2)/M phase by facilitating association of 14-3-3 and Cdc25C, HIV-1 Vpr inactivates the cdc2-cyclin B kinase complex by inactivating cdc25C, the phosphatase that dephosphorylates and activates cdc2, HIV-1 Vpr induces subcellular relocalization of Cdc25 from nuclear to cytoplasm and Vpr-induced nuclear exclusion of Cdc25 depends on the serine/threonine phosphorylation of Cdc25 and the presence of Rad24/14-3-3 protein, Inactivation of the cdc2-cyclin B kinase complex through Cdc25c and arrest in the G2 phase of the cell cycle has been mapped to the C-terminus of HIV-1 Vpr, including amino acids 73, 80 and 84-96, Kinase Srk1 is required for the Vpr-mediated nuclear export of Cdc25, Rupture of HIV-1 Vpr-induced nuclear envelope herniations produces transient loss of the subcellular compartmentalization of Wee1, Cdc25C, cyclin B1, and presumably other soluble cellular components, resulting in their release into the cytoplasm, The human Vpr interacting protein (hVIP/MOV34) is a likely cellular cofactor for HIV-1 Vpr inactivation of the cdc2-cyclin B kinase complex through Cdc25c and induction of cell cycle arrest, Vpr-induced cell cycle G2/M arrest reveals a dramatic increase in the amount of Cdk1, Cdc25C, and CyclinB1 bound to 14-3-3 theta
entrezgene:keyphrase
interacts with, relocalizes, binds, induces release of, complexes with, inactivates