Source:http://linkedlifedata.com/resource/entrezgene/hivinteraction/155807-7465
| Predicate | Object |
|---|---|
| rdf:type | |
| entrezgene:pubmed |
pubmed-article:11531413,
pubmed-article:11691994,
pubmed-article:12525641,
pubmed-article:15142377,
pubmed-article:15254189,
pubmed-article:15265780,
pubmed-article:15725353,
pubmed-article:15780175,
pubmed-article:15817944,
pubmed-article:16354571,
pubmed-article:16429131,
pubmed-article:17586317,
pubmed-article:18385244,
pubmed-article:18514189,
pubmed-article:19020832,
pubmed-article:19275588,
pubmed-article:20012529,
pubmed-article:21318276
|
| entrezgene:interactant | |
| entrezgene:geneRifText |
HIV-1 Vpr binds to Wee1. Amino acids 291-369 in Wee1 are required for the binding between Vpr and Wee1. Vpr stimulates Wee1 kinase activity,
HIV-1 Vpr induced cell cycle arrest in the G2 phase is mediated predominately through the Wee1 kinase in fission yeast,
HIV-1 Vpr-induced cell cycle arrest results in increased levels of Wee-1 kinase in synchronized HeLa cells; G2 arrest by Vpr is correlated with delayed degradation of Wee-1, and Cdc2 activity is reduced at G2/M in the presence of Vpr,
Overexpression of Wee-1 kinase suppresses HIV-1 Vpr-mediated apoptosis,
Prolonged cell cycle arrest in the G2 phase induced by HIV-1 Vpr results in the depletion of Wee1 kinase,
Rupture of HIV-1 Vpr-induced nuclear envelope herniations produces transient loss of the subcellular compartmentalization of Wee1, Cdc25C, cyclin B1, and presumably other soluble cellular components, resulting in their release into the cytoplasm
|
| entrezgene:keyphrase |
downregulates,
interacts with,
inhibited by,
upregulates,
binds,
induces release of
|