Source:http://www4.wiwiss.fu-berlin.de/dailymed/resource/drugs/912
| Predicate | Object |
|---|---|
| rdf:type | |
| rdfs:label |
Betamethasone Valerate (Cream)
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| dailymed-instance:dosage |
Betamethasone Valerate Cream USP, 0.1% is generally applied to the affected skin areas one to three times daily. Dosage once or twice a day is often effective. Occlusive dressings may be used for the management of psoriasis or recalcitrant conditions. If an infection develops, the use of occlusive dressing should be discontinued and appropriate antimicrobial therapy instituted.
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| dailymed-instance:descripti... |
Betamethasone Valerate Cream USP, 0.1% contains a topical corticosteroid, betamethasone valerate. The topical corticosteroids constitute a class of primarily synthetic steroids used as anti-inflammatory and antipruritic agents. Betamethasone valerate is chemically designated as Pregna-1, 4-diene-3, 20-dione, 9-fluoro-11, 21-dihydroxy-16-methyl-17 [(1-oxopentyl) oxy], (11��, 16��)-. Each gram of Betamethasone Valerate Cream USP, 0.1% contains: 1.2 mg betamethasone valerate USP (equivalent to 1.0 mg betamethasone) with mineral oil, white petrolatum, ceteth-20, cetyl alcohol, stearyl alcohol, propylene glycol, phosphoric acid, sodium phosphate monobasic, sodium hydroxide, purified water and 4-chloro-m-cresol as a preservative.
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| dailymed-instance:clinicalP... |
Betamethasone valerate cream as a topical corticosteroid has anti-inflammatory, antipruritic and vasoconstrictive actions. The mechanism of anti-inflammatory activity of the topical corticosteroids is unclear. Various laboratory methods, including vasoconstrictor assays, are used to compare and predict potencies and/or clinical efficacies of the topical corticosteroids. There is some evidence to suggest that a recognizable correlation exists between vasoconstrictor potency and therapeutic efficacy in man.<br/>Pharmacokinetics: The extent of percutaneous absorption of topical corticosteroids is determined by many factors including the vehicle, the integrity of the epidermal barrier, and the use of occlusive dressings. Betamethasone valerate cream can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin increase percutaneous absorption. Occlusive dressings substantially increase the percutaneous absorption of topical corticosteroids. Thus, occlusive dressings may be a valuable therapeutic adjunct for treatment of resistant dermatoses . Once absorbed through the skin, betamethasone valerate cream is handled through pharmacokinetic pathways similar to systemically administered corticosteroids. Corticosteroids are bound to plasma proteins in varying degrees. They are metabolized primarily in the liver and are then excreted by the kidneys. Some of the topical corticosteroids and their metabolites are also excreted into the bile.
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| dailymed-instance:activeIng... | |
| dailymed-instance:contraind... |
Betamethasone valerate cream is contraindicated in those patients with a history of hypersensitivity to any of the components of the preparation.
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| dailymed-instance:supply |
Betamethasone Valerate Cream USP, 0.1% is supplied in 15 gram (NDC 51672-1269-1) and 45 gram (NDC 51672-1269-6) tubes.<br/>STORAGE: Store at 20��- 25��C (68��- 77��F) [see USP Controlled Room Temperature]. Protect from freezing.
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| dailymed-instance:activeMoi... | |
| dailymed-instance:inactiveI... |
dailymed-ingredient:4-chloro-m-cresol,
dailymed-ingredient:ceteth-20,
dailymed-ingredient:cetyl_alcohol,
dailymed-ingredient:mineral_oil,
dailymed-ingredient:phosphoric_acid,
dailymed-ingredient:propylene_glycol,
dailymed-ingredient:sodium_hydroxide,
dailymed-ingredient:sodium_phosphate_monobasic,
dailymed-ingredient:stearyl_alcohol,
dailymed-ingredient:water,
dailymed-ingredient:white_petrolatum
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| dailymed-instance:overdosag... |
Topically applied corticosteroids can be absorbed in sufficient amounts to produce systemic effects .
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| dailymed-instance:genericMe... |
Betamethasone Valerate
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| dailymed-instance:fullName |
Betamethasone Valerate (Cream)
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| dailymed-instance:adverseRe... |
The following local adverse reactions are reported infrequently with topical corticosteroids, but may occur more frequently with the use of occlusive dressings. These reactions are listed in an approximate decreasing order of occurrence:
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| dailymed-instance:indicatio... |
Betamethasone valerate cream is indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.
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| dailymed-instance:represent... | |
| dailymed-instance:routeOfAd... | |
| dailymed-instance:name |
Betamethasone Valerate
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