Source:http://www4.wiwiss.fu-berlin.de/dailymed/resource/drugs/85
| Predicate | Object |
|---|---|
| rdf:type | |
| rdfs:label |
Permapen (Injection, Suspension)
|
| dailymed-instance:dosage |
Administer by deep IM injection in the upper outer quadrant of the buttock. In infants and small children, the mid-lateral aspect of the thigh may be preferable. When doses are repeated, vary the injection site .<br/>Pediatric Dosage Schedule: In children under 12 years of age, dosage should be adjusted in accordance with the age and weight of the child and the severity of the infection. Under 2 years of age, the dose may be divided between the two buttocks if necessary.<br/>Streptococcal Infections (group A) pharyngitis: A single injection of 900,000 units for older children; l,200,000 units for adults.<br/>Venereal Infections:<br/>Syphilis: Primary, secondary, and latent: 2.4 million units (1 dose).<br/>Late Syphilis (tertiary and neurosyphilis): 3 million units at 7 day intervals for a total of 6���9 million units.<br/>Congenital Syphilis (asymptomatic with normal cerebrospinal fluid): Under 2 years of age���50,000 units/kg body weight in a single dose; ages 2���12 years���adjust dosage based on adult dosage schedule.<br/>Yaws, Bejel, and Pinta: 1.2 million units (1 injection).<br/>Prophylaxis: For rheumatic fever and glomerulonephritis. Following an acute attack, penicillin G benzathine (parenteral) may be given in doses of 1,200,000 units once a month or 600,000 units every 2 weeks. Parenteral drug products should be visually inspected for particulate matter and discoloration prior to administration, whenever solution and container permit.
|
| dailymed-instance:descripti... |
Permapen' (Penicillin G Benzathine) Injectable Suspension, a sterile antibacterial agent, is a repository penicillin compound which provides blood levels for long periods following its intramuscular injection. This property is the result of its extremely low solubility in water. Each milliliter contains 600,000 units of penicillin G benzathine; 0.006 grams sodium citrate; 0.003 grams polyvinylpyrrolidone; 0.010 grams lecithin, and 0.003 grams sodium carboxymethylcellulose in an aqueous suspension. Permapen also contains methylparaben 0.09% and propylparaben 0.01% as preservatives. Chemically, Permapen is 3,3-dimethyl-7-oxo-6-(2-phenylacetamido)-4 thia-l azabicyclo [3.2.0] heptane-2-carboxylic acid compound with N,N'-dibenzylethylenediamine (2:1) tetrahydrate. It is prepared by the reaction of dibenzyl-tetrahydrate-ethylenediamine with 2 molecules of penicillin G. It has a molecular weight of 981.19 and the following chemical structure: Formula CHN���2CHNOS���4HO Penicillin G benzathine occurs as a white crystalline powder and is very slightly soluble in water. The pH of the injectable suspension is between 5.0���7.5.
|
| dailymed-instance:clinicalP... |
Intramuscular penicillin G benzathine is absorbed very slowly into the blood stream from the intramuscular site and converted by hydrolysis to penicillin G. This combination of hydrolysis and slow absorption results in blood serum levels much lower than those of other parenteral penicillins. Approximately 60% of penicillin G is bound to serum protein. The drug is distributed throughout the body tissues in widely varying amounts. Highest levels are found in the kidneys with lesser amounts in the liver, skin, and intestines. Penicillin G penetrates into all other tissues and the spinal fluid to a lesser degree. With normal kidney function the drug is excreted rapidly by tubular excretion. A small amount is secreted into the bile. In neonates and young infants, and in individuals with impaired kidney function, excretion is considerably delayed.<br/>Microbiology: Penicillin G exerts a bactericidal action against penicillin-susceptible microorganisms during the stage of active multiplication. It acts through the inhibition of biosynthesis of cell wall mucopeptide. It is not active against the penicillinase-producing bacteria, which includes many strains of staphylococci. While in vitro studies have demonstrated the susceptibility of most strains of the following organisms, clinical efficacy for infections other than those included in the INDICATIONS AND USAGE section has not been documented. Penicillin G exerts high in vitro activity against staphylococci (except penicillinase-producing strains), streptococci (groups A, C, G, H, L, and M), and pneumococci. Other organisms sensitive to penicillin G are: Corynebacterium diphtheriae, Bacillus anthracis, Clostridia, Actinomyces bovis, Streptobacillus moniliformis, Listeria monocytogenes, and Leptospira. Treponema pallidum is extremely sensitive to the bactericidal action of penicillin G. Penicillin acts synergistically with gentamicin or tobramycin against many strains of enterococci.
|
| dailymed-instance:activeIng... | |
| dailymed-instance:contraind... |
A history of a previous hypersensitivity reaction to any penicillin is a contraindication.
|
| dailymed-instance:supply |
Permapen (Penicillin G Benzathine) Injectable Suspension is supplied in an ISOJECT syringe: 1,200,000 units in packages of 10 (NDC 0049-0210-35). ISOJECT is a pre-filled disposable syringe unit with a 20-gauge, 1��inch needle. Each 2 mL contains 1,200,000 units penicillin G benzathine; 0.0l2 g sodium citrate; 0.006 g polyvinylpyrrolidone; 0.020 g lecithin, and 0.006 g sodium carboxymethylcellulose. Preservatives: methylparaben 0.09%, propylparaben 0.01%. The product should be stored between 2�����8��C (36�����46��F). Keep from freezing.
|
| dailymed-instance:inactiveI... | |
| dailymed-instance:overdosag... |
Penicillin in overdosage has the potential to cause neuromuscular hyperirritability. In case of overdosage discontinue medication, treat symptomatically, and institute supportive measures as required. Penicillin G is hemodialyzable.
|
| dailymed-instance:genericMe... |
penicillin G benzathine
|
| dailymed-instance:fullName |
Permapen (Injection, Suspension)
|
| dailymed-instance:adverseRe... |
The hypersensitivity reactions reported are skin eruptions (maculopapular to exfoliative dermatitis), urticaria and other serum sickness reactions, laryngeal edema and anaphylaxis. Fever and eosinophilia may frequently be the only reaction observed. Hemolytic anemia, leucopenia, thrombocytopenia, neuropathy, and nephropathy are infrequent reactions and usually associated with high doses of parenteral penicillin.
|
| dailymed-instance:warning |
Serious and occasionally fatal hypersensitivity (anaphylactoid) reactions have been reported in patients on penicillin therapy. These reactions are more likely to occur in individuals with a history of penicillin hypersensitivity and/or a history of sensitivity to multiple allergens. There have been reportsof individuals with a history of penicillin hypersensitivity who have experienced severe reactions when treated with cephalosporins. Before initiating therapy with any penicillin, careful inquiry should be made concerning previous hypersensitivity reactions to penicillin, cephalosporins, and other allergens. If an allergic reaction occurs, the drug should be discontinued and the appropriate therapy instituted. Serious anaphylactoid reactions require immediate emergency treatment with epinephrine. Oxygen, intravenous steroids, and airway management���including intubation, should be administered as indicated.
|
| dailymed-instance:indicatio... |
Intramuscular penicillin G benzathine is indicated in the treatment of infections in both children and adults due to penicillin G-susceptible microorganisms that are susceptible to the low and very prolonged serum levels common to this particular dosage form in the indications listed below. Therapy should be guided by clinical response. Note: When high sustained serum levels are required, injectable penicillin G either IM or IV should be used. The following infections will usually respond to adequate dosages of intramuscular penicillin G benzathine: Upper Respiratory Tract (pharyngitis): streptococci (group A���without bacteremia). Venereal Infections: Syphilis Yaws, bejel, and pinta.
|
| dailymed-instance:represent... | |
| dailymed-instance:routeOfAd... | |
| dailymed-instance:name |
Permapen
|