Source:http://www4.wiwiss.fu-berlin.de/dailymed/resource/drugs/839
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Desoximetasone (Gel)
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Apply a thin film of Desoximetasone Cream USP, 0.05% or Desoximetasone Cream USP, 0.25% or Desoximetasone Gel USP, 0.05% or Desoximetasone Ointment USP, 0.25% to the affected skin areas twice daily. Rub in gently.
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| dailymed-instance:descripti... |
Desoximetasone Cream USP, 0.05%; Desoximetasone Cream USP, 0.25%; Desoximetasone Gel USP, 0.05% and Desoximetasone Ointment USP, 0.25% contain desoximetasone a synthetic fluorinated corticosteroid for topical dermatologic use. The corticosteroids constitute a class of primarily synthetic steroids used topically as anti-inflammatory and anti-pruritic agents. Chemically, desoximetasone is Pregna-1, 4-diene-3, 20-dione, 9-fluoro-11,21-dihydroxy-16-methyl-, (11��, 16��)-. It has the molecular formula CHFOand a molecular weight of 376.47. The CAS Registry Number is 382-67-2. The chemical structure is: Desoximetasone is a white to off-white, odorless, crystalline powder and is soluble in alcohol, acetone, chloroform, and hot ethyl acetate; slightly soluble in ether and benzene; and insoluble in water, dilute aqueous acids and alkalis. Each gram of Desoximetasone Cream USP, 0.05% contains 0.5 mg of desoximetasone in an emollient cream consisting of white petrolatum, purified water, isopropyl myristate, lanolin alcohols, mineral oil, cetostearyl alcohol and edetate disodium. Each gram of Desoximetasone Cream USP, 0.25% contains 2.5 mg of desoximetasone in an emollient cream consisting of white petrolatum, purified water, isopropyl myristate, lanolin alcohols, mineral oil and cetostearyl alcohol. Each gram of Desoximetasone Gel USP, 0.05% contains 0.5 mg of desoximetasone in a gel base consisting of purified water, docusate sodium, edetate disodium, isopropyl myristate, carbomer 940, trolamine, and SDAG-3 95% alcohol. Each gram of Desoximetasone Ointment USP, 0.25% contains 2.5 mg of desoximetasone in an ointment base consisting of white petrolatum and fractionated coconut oil.
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| dailymed-instance:clinicalP... |
The corticosteroids are a class of compounds comprising steroid hormones secreted by the adrenal cortex and their synthetic analogs. In pharmacologic doses, corticosteroids are used primarily for their anti-inflammatory and/or immunosuppressive effects. Topical corticosteroids, such as desoximetasone, are effective in the treatment of corticosteroid-responsive dermatoses primarily because of their anti-inflammatory, antipruritic, and vasoconstrictive actions. However, while the physiologic, pharmacologic, and clinical effects of the corticosteroids are well known, the exact mechanisms of their actions in each disease are uncertain.Desoximetasone, a corticosteroid, has been shown to have topical (dermatologic) and systemic pharmacologic and metabolic effects characteristic of this class of drugs.<br/>Pharmacokinetics: The extent of percutaneous absorption of topical corticosteroids is determined by many factors including the vehicle and the integrity of the epidermal barrier, and the use of occlusive dressings. Topical corticosteroids can be absorbed through normal intact skin. Inflammation and/or other disease processes in the skin may increase percutaneous absorption. Occlusive dressings substantially increase the percutaneous absorption of topical corticosteroids. Once absorbed through the skin, topical corticosteroids enter pharmacokinetic pathways similar to systemically administered corticosteroids. Corticosteroids are bound to plasma proteins in varying degrees, are metabolized primarily in the liver and excreted by the kidneys. Some of the topical corticosteroids and their metabolites are also excreted into the bile. Pharmacokinetic studies in men with Desoximetasone Cream USP, 0.25% with tagged desoximetasone showed a total of 5.2%��2.9% excretion in urine (4.1%��2.3%) and feces (1.1%��0.6%) and no detectable level (limit of sensitivity: 0.005��g/mL) in the blood when it was applied topically on the back followed by occlusion for 24 hours. Seven days after application, no further radioactivity was detected in urine or feces. The half-life of the material was 15��2 hours (for urine) and 17��2 hours (for feces) between the third and fifth trial day. Studies with other similarly structured steroids have shown that predominant metabolite reaction occurs through conjugation to form the glucuronide and sulfate ester. Studies performed with Desoximetasone Cream USP, 0.05%; Desoximetasone Cream USP, 0.25%; Desoximetasone Gel USP, 0.05% and Desoximetasone Ointment USP, 0.25% indicate that they are in the high range of potency as compared with other topical corticosteroids.
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Topical corticosteroids are contraindicated in those patients with a history of hypersensitivity to any of the components of the preparation.
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| dailymed-instance:supply |
Desoximetasone Cream USP, 0.05% is supplied in 15 gram (NDC 51672-1271-1) and 60 gram (NDC 51672-1271-3) tubes. Desoximetasone Cream USP, 0.25% is supplied in 15 gram (NDC 51672-1270-1) and 60 gram (NDC 51672-1270-3) tubes. Desoximetasone Gel USP, 0.05% is supplied in 15 gram (NDC 51672-1261-1) and 60 gram (NDC 51672-1261-3) tubes. Desoximetasone Ointment USP, 0.25% is supplied in 15 gram (NDC 51672-1262-1) and 60 gram (NDC 51672-1262-3) tubes. Store at 20��- 25��C (68��- 77��F) [see USP Controlled Room Temperature].
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Topically applied Desoximetasone Cream USP, 0.05%; Desoximetasone Cream USP, 0.25%; Desoximetasone Gel USP, 0.05% and Desoximetasone Ointment USP, 0.25% can be absorbed in sufficient amounts to produce systemic effects .
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| dailymed-instance:genericMe... |
Desoximetasone
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| dailymed-instance:fullName |
Desoximetasone (Gel)
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| dailymed-instance:adverseRe... |
In controlled clinical studies the incidence of adverse reactions was low (0.8%) for Desoximetasone Cream USP, 0.05% and included pruritus, erythema, vesiculation and burning sensation. The incidence of adverse reactions was also 0.8% for Desoximetasone Cream USP, 0.25% and included burning, folliculitis, and folliculopustular lesions. The incidence of adverse reactions for Desoximetasone Gel USP, 0.05% was 0.3% with one subject reporting stinging and burning at the site of application. The incidence of adverse reactions for Desoximetasone Ointment USP, 0.25% was also 0.3% and consisted of development of comedones at the site of application. The following local adverse reactions are reported infrequently when topical corticosteroids are used as recommended but may occur more frequently with the use of occlusive dressings and higher potency corticosteroids. These are listed in an approximate decreasing order of occurrence: burning, itching, irritation, dryness, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infection, skin atrophy, striae, and miliaria. Systemic absorption of topical corticosteroids has produced hypothalamic-pituitary-adrenal (HPA) axis suppression, manifestations of Cushing's syndrome, hyperglycemia, and glucosuria in some patients.
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| dailymed-instance:warning |
Desoximetasone Cream USP, 0.05%; Desoximetasone Cream USP, 0.25%; Desoximetasone Gel USP, 0.05% and Desoximetasone Ointment USP, 0.25% are not for ophthalmic use. Keep out of reach of children.
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| dailymed-instance:indicatio... |
Topical corticosteroids are high potency corticosteroids indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid responsive dermatoses.
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Desoximetasone
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