| dailymed-drugs:756 | rdf:type | http://www4.wiwiss.fu-berli... | lld:dailymed |
| dailymed-drugs:756 | rdf:type | dailymed-instance:drugs | lld:dailymed |
| dailymed-drugs:756 | rdfs:label | Rapamune (Tablet, Sugar Coated) | lld:dailymed |
| dailymed-drugs:756 | dailymed-instance:activeIng... | dailymed-ingredient:sirolim... | lld:dailymed |
| dailymed-drugs:756 | dailymed-instance:genericDr... | http://www4.wiwiss.fu-berli... | lld:dailymed |
| dailymed-drugs:756 | dailymed-instance:boxedWarn... | BOX WARNING: IMMUNOSUPPRESSION, EXCESS MORTALITY IN DE NOVO LIVER TRANSPLANTATION, AND BRONCHIAL
ANASTOMOTIC DEHISCENCE: Increased susceptibility to infection and the possible
development of lymphoma may result from immunosuppression. Only physicians
experienced in immunosuppressive therapy and management of renal transplant
patients should use Rapamune. Patients receiving the drug should be managed in
facilities equipped and staffed with adequate laboratory and supportive
medical resources. The physician responsible for maintenance therapy
should have complete information requisite for the follow-up of the
patient [see Warnings
and Precautions (5.1)]. The use of Rapamune in combination with tacrolimus was associated
with excess mortality and graft loss in a study in de novo liver transplant patients. Many
of these patients had evidence of infection at or near the time of
death. In this and another study in de novo liver transplant patients, the
use of Rapamune in combination with cyclosporine or tacrolimus was
associated with an increase in HAT; most cases of HAT occurred within
30 days post-transplantation and most led to graft loss or death [see Warnings and Precautions (5.2)]. Cases of bronchial anastomotic dehiscence, most fatal,
have been reported in de novo lung transplant patients when Rapamune has been used as part of
an immunosuppressive regimen [see Warnings and Precautions (5.3)]. | lld:dailymed |
| dailymed-drugs:756 | dailymed-instance:activeMoi... | dailymed-ingredient:sirolim... | lld:dailymed |
| dailymed-drugs:756 | dailymed-instance:inactiveI... | dailymed-ingredient:lactose | lld:dailymed |
| dailymed-drugs:756 | dailymed-instance:inactiveI... | dailymed-ingredient:magnesi... | lld:dailymed |
| dailymed-drugs:756 | dailymed-instance:inactiveI... | dailymed-ingredient:microcr... | lld:dailymed |
| dailymed-drugs:756 | dailymed-instance:inactiveI... | dailymed-ingredient:povidon... | lld:dailymed |
| dailymed-drugs:756 | dailymed-instance:inactiveI... | dailymed-ingredient:sucrose | lld:dailymed |
| dailymed-drugs:756 | dailymed-instance:inactiveI... | dailymed-ingredient:titaniu... | lld:dailymed |
| dailymed-drugs:756 | dailymed-instance:inactiveI... | dailymed-ingredient:talc | lld:dailymed |
| dailymed-drugs:756 | dailymed-instance:inactiveI... | dailymed-ingredient:polyeth... | lld:dailymed |
| dailymed-drugs:756 | dailymed-instance:inactiveI... | dailymed-ingredient:pharmac... | lld:dailymed |
| dailymed-drugs:756 | dailymed-instance:inactiveI... | dailymed-ingredient:carnaub... | lld:dailymed |
| dailymed-drugs:756 | dailymed-instance:inactiveI... | dailymed-ingredient:calcium... | lld:dailymed |
| dailymed-drugs:756 | dailymed-instance:inactiveI... | dailymed-ingredient:poloxam... | lld:dailymed |
| dailymed-drugs:756 | dailymed-instance:inactiveI... | dailymed-ingredient:polyeth... | lld:dailymed |
| dailymed-drugs:756 | dailymed-instance:inactiveI... | dailymed-ingredient:glycery... | lld:dailymed |
| dailymed-drugs:756 | dailymed-instance:inactiveI... | dailymed-ingredient:dl-alph... | lld:dailymed |
| dailymed-drugs:756 | dailymed-instance:inactiveI... | dailymed-ingredient:other_i... | lld:dailymed |
| dailymed-drugs:756 | dailymed-instance:genericMe... | Sirolimus | lld:dailymed |
| dailymed-drugs:756 | dailymed-instance:fullName | Rapamune (Tablet, Sugar Coated) | lld:dailymed |
| dailymed-drugs:756 | dailymed-instance:represent... | http://www4.wiwiss.fu-berli... | lld:dailymed |
| dailymed-drugs:756 | dailymed-instance:routeOfAd... | http://www4.wiwiss.fu-berli... | lld:dailymed |
| dailymed-drugs:756 | dailymed-instance:name | Rapamune | lld:dailymed |
| http://www4.wiwiss.fu-berli... | dailymed-instance:producesD... | dailymed-drugs:756 | lld:dailymed |
