Source:http://www4.wiwiss.fu-berlin.de/dailymed/resource/drugs/590
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Oxybutynin Chloride (Syrup)
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| dailymed-instance:dosage |
Syrup:<br/>Adults: The usual dose is one teaspoonful (5 mg/5 mL) oral solution two to three times a day. The maximum recommended dose is one teaspoonful (5 mg/5 mL) oral solution four times a day.<br/>Pediatric patients over 5 years of
age: The usual dose is one teaspoonful (5 mg/5 mL) two times a day. The maximum recommended dose is one teaspoonful (5 mg/5 mL) three times a day.
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| dailymed-instance:descripti... |
Each 5 mL (teaspoonful) of Oxybutynin Chloride Oral Solution USP, for oral administration contains 5 mg of oxybutynin chloride. Chemically, oxybutynin chloride is 4-(diethylamino)-2-butynyl (��)-a-phenylcyclohexaneglycolate hydrochloride. The molecular formula of oxybutynin chloride is CHNO���HCl. The structural formula appears below: Oxybutynin chloride is a white crystalline solid with a molecular weight of 393.96. It is readily soluble in water and acids, but relatively insoluble in alkalis. Oxybutynin Chloride Oral Solution USP 5 mg/5 mL Also contains: citric acid, FD&C Green #3, glycerin, methyl paraben, artificial berry flavor, sodium citrate, sorbitol, sucrose and water. Therapeutic Category: Antispasmodic, anticholinergic.
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| dailymed-instance:clinicalP... |
Oxybutynin chloride exerts direct antispasmodic effect on smooth muscle and inhibits the muscarinic action of acetylcholine on smooth muscle. Oxybutynin chloride exhibits only one fifth of the anticholinergic activity of atropine on the rabbit detrusor muscle, but four to ten times the antispasmodic activity. No blocking effects occur at skeletal neuromuscular junctions or autonomic ganglia (antinicotinic effects). Oxybutynin chloride relaxes bladder smooth muscle. In patients with conditions characterized by involuntary bladder contractions, cystometric studies have demonstrated that oxybutynin chloride increases bladder (vesical) capacity, diminishes the frequency of uninhibited contractions of the detrusor muscle, and delays the initial desire to void. Oxybutynin chloride thus decreases urgency and the frequency of both incontinent episodes and voluntary urination. Oxybutynin chloride was well tolerated in patients administered the drug in controlled studies of 30 days' duration and in uncontrolled studies in which some of the patients received the drug for 2 years. Pharmacokinetic information is not currently available.
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| dailymed-instance:supply |
Oxybutynin Chloride Oral Solution USP (5 mg/5 mL) is a clear, light bluish-green liquid, artificially berry flavored and is supplied in bottles of 16 fluid ounces (473 mL), (NDC 60505-6008-9). Pharmacist: Dispense in tight, light-resistant container as defined in the USP. Store at 20��- 25��C (68��- 77��F) [See USP Controlled Room Temperature].
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| dailymed-instance:precautio... |
General: Oxybutynin chloride should be used with caution in the elderly and in all patients with autonomic neuropathy, hepatic or renal disease. Oxybutynin chloride may aggravate the symptoms of hyperthyroidism, coronary heart disease, congestive heart failure, cardiac arrhythmias, hiatal hernia, tachycardia, hypertension, and prostatic hypertrophy. Administration of oxybutynin chloride to patients with ulcerative colitis may suppress intestinal motility to the point of producing a paralytic ileus and precipitate or aggravate toxic megacolon, a serious complication of the disease.<br/>Carcinogenesis, Mutagenesis, Impairment
of Fertility: A 24-month study in rats at dosages up to approximately 400 times the recommended human dosage showed no evidence of carcinogenicity. Oxybutynin chloride showed no increase of mutagenic activity when tested in Schizosaccharomyces pompholiciformis, Saccharomyces cerevisiae and Salmonella typhimurium test systems. Reproduction studies in the hamster, rabbit, rat, and mouse have shown no definite evidence of impaired fertility.<br/>Pregnancy: Teratogenic Effects, Pregnancy Category B. Reproduction studies in the hamster, rabbit, rat, and mouse have shown no definite evidence of impaired fertility or harm to the animal fetus. The safety of oxybutynin chloride administered to women who are or who may become pregnant has not been established. Therefore, oxybutynin chloride should not be given to pregnant women unless, in the judgment of the physician, the probable clinical benefits outweigh the possible hazards.<br/>Nursing Mothers: It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when oxybutynin chloride is administered to a nursing woman.<br/>Pediatric Use: The safety and efficacy of oxybutynin chloride administration have been demonstrated for pediatric patients 5 years of age and older (see DOSAGE AND ADMINISTRATION). However, as there is insufficient clinical data for pediatric populations under age 5, oxybutynin chloride is not recommended for this age group.
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| dailymed-instance:overdosag... |
The symptoms of overdosage with oxybutynin chloride may be any of those seen with other anticholinergic agents. Symptoms may include signs of central nervous system excitation (eg. restlessness, tremor, irritability, convulsions, delirium, hallucinations), flushing, fever, nausea, vomiting, tachycardia, hypotension or hypertension, respiratory failure, paralysis, and coma. In the event of an overdose or exaggerated response, treatment should be symptomatic and supportive. Maintain respiration and induce emesis or perform gastric lavage (emesis is contraindicated in precomatose, convulsive, or psychotic state). Activated charcoal may be administered as well as a cathartic. Physostigmine may be considered to reverse symptoms of anticholinergic intoxication. Hyperpyrexia may be treated symptomatically with ice bags or other cold applications and alcohol sponges.
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| dailymed-instance:genericMe... |
oxybutynin chloride
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| dailymed-instance:fullName |
Oxybutynin Chloride (Syrup)
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| dailymed-instance:adverseRe... |
Following administration of oxybutynin chloride, the symptoms that can be associated with the use of other anticholinergic drugs may occur: Cardiovascular: Palpitations, tachycardia, vasodilatation. Dermatologic: Decreased sweating, rash. Gastrointestinal/Genitourinary: Constipation, decreased gastrointestinal motility, dry mouth, nausea, urinary hesitance and retention. Nervous System: Asthenia, dizziness, drowsiness, hallucinations, insomnia, restlessness. Ophthalmic: Amblyopia, cycloplegia, decreased lacrimation, mydriasis. Other: Impotence, suppression of lactation.
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| dailymed-instance:indicatio... |
Oxybutynin chloride oral solution is indicated for the relief of symptoms of bladder instability associated with voiding in patients with uninhibited neurogenic or reflex neurogenic bladder (ie. urgency, frequency, urinary leakage, urge incontinence, dysuria).
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| dailymed-instance:name |
Oxybutynin Chloride
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