Source:http://www4.wiwiss.fu-berlin.de/dailymed/resource/drugs/4220
| Predicate | Object |
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| rdf:type | |
| rdfs:label |
Sterile Water (Injection, Solution)
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| dailymed-instance:dosage |
Sterile Water for Injection, USP in the 2000 mL flexible
Pharmacy Bulk Package is designed for use with automated compounding
devices for preparing intravenous admixtures. Dosages will be in accordance
with the recommendation of the prescribing physician. Sterile Water for Injection, USP is not intended for direct infusion.
Admixtures should be made by or under the direction of a pharmacist
using strict aseptic technique under a laminar flow hood. Compounded
admixtures may be stored under refrigeration for up to 24 hours. Administration
of admixtures should be completed within 24 hours after removal from
refrigeration.<br/>Drug Interactions: The Pharmacy Bulk Package is intended only for use
in the preparation of sterile, intravenous admixtures using automated
compounding devices. Additives may be incompatible
with the fluid withdrawn from this container. Consult with pharmacist,
if available. When compounding admixtures, use aseptic technique,
mix thoroughly and do not store. Parenteral
drug products should be inspected visually for particulate matter
and discoloration prior to administration, whenever solution container
permits. See PRECAUTIONS. Some opacity of the
plastic due to moisture absorption during the sterilization process
may be observed. This is normal and does not affect the solution quality
or safety. The opacity will diminish gradually. Recommended Directions for Use of the Pharmacy
Bulk Package Use Aseptic Technique
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| dailymed-instance:descripti... |
Sterile Water for Injection, USP is a sterile, nonpyrogenic
water for injection intended only for dilution purposes. The pH is
5.4 (5.0 to 7.0). The Pharmacy Bulk Package is a sterile dosage form
which contains multiple single doses for use only in a pharmacy bulk
admixture program. Sterile Water for Injection,
USP contains no bacteriostat, antimicrobial agent or added buffer. Sterile Water for Injection, USP may be classified as
a sterile diluent and pharmaceutical vehicle. Sterile Water for Injection, USP is chemically designated HO. The flexible plastic container is fabricated
from a specially formulated polyvinylchloride. Water can permeate
from inside the container into the overwrap but not in amounts sufficient
to affect the solution significantly. Solutions inside the plastic
container also can leach out certain of its chemical components in
very small amounts before the expiration period is attained. However,
the safety of the plastic has been confirmed by tests in animals according
to USP biological standards for plastic containers.
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| dailymed-instance:clinicalP... |
Water is an essential constituent of all body tissues
and accounts for approximately 70% of total body weight. Average normal
adult daily requirement ranges from two to three liters (1.0 to 1.5 liters
each for insensible water loss by perspiration and urine production). Water balance is maintained by various regulatory mechanisms.
Water distribution depends primarily on the concentration of electrolytes
in the body compartments and sodium (Na) plays a major
role in maintaining physiologic equilibrium.
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| dailymed-instance:activeIng... | |
| dailymed-instance:contraind... |
NOT FOR DIRECT INFUSION. DO NOT USE FOR NON-AUTOMATED
ADMIXTURE PREPARATIONS.
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| dailymed-instance:supply |
Sterile Water for Injection, USP is supplied in 2000
mL flexible Pharmacy Bulk Packages (List No. 7118). Store at 20 to 25��C (68 to 77��F). [See USP Controlled
Room Temperature.] Protect from freezing. Patent
4,368,765 Revised: May, 2006 Hospira, Inc., Lake Forest, IL 60045 USA
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| dailymed-instance:boxedWarn... |
Pharmacy Bulk Package���Not for Direct Infusion. FOR USE ONLY WITH AUTOMATED COMPOUNDING DEVICES.
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| dailymed-instance:activeMoi... | |
| dailymed-instance:precautio... |
Do not use unless water is clear, seal is intact
and container is undamaged. Aseptic technique
is essential with the use of sterile preparations for compounding
admixtures. Discard container within 4 hours
of entering closure.
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| dailymed-instance:genericMe... |
Water
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| dailymed-instance:fullName |
Sterile Water (Injection, Solution)
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| dailymed-instance:adverseRe... |
Accidental contamination from careless technique
may transmit infection. Should any adverse reaction
occur, evaluate the patient, institute appropriate therapeutic countermeasures
and save the remainder of the fluid for examination, if deemed necessary.
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| dailymed-instance:warning |
FOR DILUTION ONLY. Do not heat
over 66��C (150��F). This preparation
is solute-free and its entry into
the circulation undiluted will cause hemolysis. Absorption of large amounts of Sterile Water
for Injection, USP with additives can cause fluid and/or solute overloading
resulting in dilution of serum electrolyte concentrations, overhydration,
congested states or pulmonary edema. The risk of dilutional states
is inversely proportional to the electrolyte concentrations of administered
solutions. The risk of solute overload causing congested states with
peripheral and pulmonary edema is directly proportional to the electrolyte
concentrations of such solutions. WARNING:
This product contains aluminum that may be toxic. Aluminum may reach
toxic levels with prolonged parenteral administration if kidney function
is impaired. Premature neonates are particularly at risk because their
kidneys are immature, and they require large amounts of calcium and
phosphate solutions, which contain aluminum. Research indicates that patients with impaired kidney function, including
premature neonates, who receive parenteral levels of aluminum at greater
than 4 to 5 mcg/kg/day accumulate aluminum at levels associated with
central nervous system and bone toxicity. Tissue loading may occur
at even lower rates of administration.
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| dailymed-instance:indicatio... |
Sterile Water for Injection, USP in the Pharmacy
Bulk Package is indicated for use with automated compounding devices
for preparing intravenous admixtures in the pharmacy.
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| dailymed-instance:represent... | |
| dailymed-instance:routeOfAd... | |
| dailymed-instance:name |
Sterile Water
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