Source:http://www4.wiwiss.fu-berlin.de/dailymed/resource/drugs/3966
| Predicate | Object |
|---|---|
| rdf:type | |
| rdfs:label |
NYSTATIN (Powder)
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| dailymed-instance:dosage |
Very moist lesions are best treated with the topical dusting powder. Adults and Pediatric Patients (Neonates and Older): Apply to candidal lesions two or three times daily until healing
is complete. For fungal infection of the feet caused by Candida species,
the powder should be dusted on the feet, as well as, in all foot wear.
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| dailymed-instance:descripti... |
Nystatin is a polyene antifungal antibiotic obtained from Streptomyces
nursei. Structural formula: Nystatin Topical Powder is for dermatologic use. Nystatin Topical Powder contains 100,000 USP nystatin units per
gram dispersed in talc.
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| dailymed-instance:clinicalP... |
Pharmacokinetics: Nystatin is not absorbed from intact skin or mucous membrane.<br/>Microbiology: Nystatin is an antibiotic which is both fungistatic and fungicidal in
vitro against a wide variety of yeasts and yeast-like fungi, including Candida
albicans, C. parapsilosis, C. tropicalis, C. guilliermondi, C. pseudotropicalis,
C. krusei, Torulopsis glabrata, Tricophyton rubrum, T. mentagrophytes. Nystatin acts by binding to sterols in the cell membrane of susceptible
species resulting in a change in membrane permeability and the subsequent
leakage of intracellular components. On repeated subculturing with increasing
levels of nystatin, Candida albicans does not develop resistance
to nystatin. Generally, resistance to nystatin does not develop during therapy.
However, other species of Candida (C. tropicalis, C. guilliermondi,
C. krusei, and C. stellatoides) become quite resistant on treatment
with nystatin and simultaneously become crossresistant to amphotericin as
well. This resistance is lost when the antibiotic is removed. Nystatin exhibits no appreciable activity against bacteria, protozoa,
or viruses.
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| dailymed-instance:activeIng... | |
| dailymed-instance:contraind... |
Nystatin topical preparations are contraindicated in patients with
a history of hypersensitivity to any of their components.
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| dailymed-instance:supply |
Nystatin Topical Powder USP: 100,000 units nystatin
per gram in 15 g (NDC 59366-5000-1) plastic squeeze bottles.<br/>STORAGE: Store at room temperature, avoid excessive heat (40��C/104��F). Keep
tightly closed.
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| dailymed-instance:genericDr... | |
| dailymed-instance:activeMoi... | |
| dailymed-instance:inactiveI... | |
| dailymed-instance:precautio... |
General: Nystatin, topical preparations should not be used for the
treatment of systemic, oral, intravaginal or ophthalmic infections. If irritation or sensitization develops, treatment should be discontinued
and appropriate measures taken as indicated. It is recommended that KOH smears,
cultures, or other diagnostic methods be used to confirm the diagnosis of
cutaneous or mucocutaneous candidiasis and to rule out infection caused by
other pathogens.<br/>INFORMATION FOR THE PATIENT: Patients using this medication should receive the following information
and instructions:<br/>Laboratory Tests: If there is a lack of therapeutic response, KOH smears, cultures,
or other diagnostic methods should be repeated.<br/>Carcinogenesis, Mutagenesis, Impairment of Fertility: No long-term animal studies have been performed to evaluate the
carcinogenic potential of nystatin. No studies have been performed to determine
the mutagenicity of nystatin or its effects on male or female fertility.<br/>Pregnancy:<br/>Teratogenic Effects: Category C. Animal reproduction studies have not been conducted
with any nystatin topical preparation. It also is not known whether these
preparations can cause fetal harm when used by a pregnant woman or can affect
reproductive capacity. Nystatin topical preparations should be prescribed
for a pregnant woman only if the potential benefit to the mother outweighs
the potential risk to the fetus.<br/>Nursing Mothers: It is not known whether nystatin is excreted in human milk. Caution
should be exercised when nystatin is prescribed for a nursing woman.<br/>Pediatric Use: Safety and effectiveness have been established in the pediatric
population from birth to 16 years.
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| dailymed-instance:genericMe... |
NYSTATIN
|
| dailymed-instance:fullName |
NYSTATIN (Powder)
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| dailymed-instance:adverseRe... |
The frequency of adverse events reported in patients using nystatin
preparations is less than 0.1%. The more common events that were reported
include allergic reactions, burning, itching, rash, eczema, and pain on application.
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| dailymed-instance:indicatio... |
Nystatin topical preparations are indicated in the treatment of
cutaneous or mucocutaneous mycotic infections caused by Candida albicans and
other susceptible Candida species. These preparations are not indicated for systemic, oral,
intravaginal or ophthalmic use.
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| dailymed-instance:represent... | |
| dailymed-instance:routeOfAd... | |
| dailymed-instance:name |
NYSTATIN
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