Source:http://www4.wiwiss.fu-berlin.de/dailymed/resource/drugs/395
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| rdf:type | |
| rdfs:label |
Topicort (Gel)
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| dailymed-instance:dosage |
Apply a thin film of Topicort LP (desoximetasone) Cream 0.05%, Topicort (desoximetasone) Cream 0.25%, and Topicort (desoximetasone) Gel 0.05% to the affected skin areas twice daily. Rub in gently.
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| dailymed-instance:descripti... |
Topicort LP (desoximetasone) Cream 0.05%; Topicort (desoximetasone) Cream 0.25%; and Topicort (desoximetasone) Gel 0.05% contain the active synthetic corticosteroid desoximetasone. The topical corticosteroids constitute a class of primarily synthetic steroids used as anti-inflammatory and antipruritic agents. Each gram of Topicort LP Cream 0.05% contains 0.5 mg of desoximetasone in an emollient cream base consisting of white petrolatum, purified water, isopropyl myristate, lanolin alcohols, mineral oil, cetostearyl alcohol, and edetate disodium. Each gram of Topicort Cream 0.25% contains 2.5 mg of desoximetasone in an emollient cream base consisting of white petrolatum, purified water, isopropyl myristate, lanolin alcohols, mineral oil, and cetostearyl alcohol. Each gram of Topicort Gel 0.05% contains 0.5 mg of desoximetasone in a gel base consisting of purified water, docusate sodium, edetate disodium, isopropyl myristate, carbomer 940, trolamine, and SDAG-3 95% alcohol. The chemical name of desoximetasone is Pregna-1, 4-diene-3, 20-dione, 9-fluoro-11, 21-dihydroxy-16-methyl-,(11��,16��)-. Desoximetasone has the molecular formula CHFOand a molecular weight of 376.47. The CAS Registry Number is 382-67-2. The structural formula is:
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| dailymed-instance:clinicalP... |
Topical corticosteroids share anti-inflammatory, antipruritic and vasoconstrictive actions. The mechanism of anti-inflammatory activity of the topical corticosteroids is unclear. Various laboratory methods, including vasoconstrictor assays, are used to compare and predict potencies and/or clinical efficacies of the topical corticosteroids. There is some evidence to suggest that a recognizable correlation exists between vasoconstrictor potency and therapeutic efficacy in man.<br/>Pharmacokinetics: The extent of percutaneous absorption of topical corticosteroids is determined by many factors including the vehicle, the integrity of the epidermal barrier, and the use of occlusive dressings. Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin increase percutaneous absorption. Occlusive dressings substantially increase the percutaneous absorption of topical corticosteroids. Thus, occlusive dressings may be a valuable therapeutic adjunct for treatment of resistant dermatoses. Once absorbed through the skin, topical corticosteroids are handled through pharmacokinetic pathways similar to systemically administered corticosteroids. Corticosteroids are bound to plasma proteins in varying degrees. Corticosteroids are metabolized primarily in the liver and are then excreted by the kidneys. Some of the topical corticosteroids and their metabolites are also excreted into the bile. Pharmacokinetic studies in men with Topicort (desoximetasone) Cream 0.25% with tagged desoximetasone showed a total of 5.2%��2.9% excretion in urine (4.1%��2.3%) and feces (1.1%��0.6%) and no detectable level (limit of sensitivity: 0.005��g/mL) in the blood when it was applied topically on the back followed by occlusion for 24 hours. Seven days after application, no further radioactivity was detected in urine or feces. The half-life of the material was 15��2 hours (for urine) and 17��2 hours (for feces) between the third and fifth trial day.
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| dailymed-instance:activeIng... | |
| dailymed-instance:contraind... |
Topical corticosteroids are contraindicated in those patients with a history of hypersensitivity to any of the components of the preparation.
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| dailymed-instance:supply |
Topicort LP (desoximetasone) Cream 0.05% is supplied in 5 gram tubes for physician samples, 15 gram and 60 gram tubes. Topicort (desoximetasone) Cream 0.25% is supplied in 5 gram tubes for physician samples, 15 gram, 60 gram, and 100 gram tubes. Topicort (desoximetasone) Gel 0.05% is supplied in 5 gram tubes for physician samples, 15 gram and 60 gram tubes. Store at controlled room temperature 15��-30��C (59��-86��F).
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| dailymed-instance:genericDr... | |
| dailymed-instance:activeMoi... | |
| dailymed-instance:inactiveI... | |
| dailymed-instance:overdosag... |
Topically applied corticosteroids can be absorbed in sufficient amounts to produce systemic effects .
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| dailymed-instance:genericMe... |
Desoximetasone
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| dailymed-instance:fullName |
Topicort (Gel)
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| dailymed-instance:adverseRe... |
The following local adverse reactions are reported infrequently with topical corticosteroids, but may occur more frequently with the use of occlusive dressings. These reactions are listed in an approximate decreasing order of occurrence: In controlled clinical studies the incidence of adverse reactions was low (0.8%) for Topicort (desoximetasone) Cream 0.25% and included burning, folliculitis, and folliculo-pustular lesions. The incidence of adverse reactions was also 0.8% for Topicort LP (desoximetasone) Cream 0.05% and included pruritus, erythema, vesiculation, and burning sensation.
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| dailymed-instance:warning |
Topicort LP (desoximetasone) Cream 0.05%; Topicort (desoximetasone) Cream 0.25%; and Topicort (desoximetasone) Gel 0.05% are not for ophthalmic use. Keep out of reach of children.
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| dailymed-instance:indicatio... |
Topicort LP (desoximetasone) Cream 0.05%; Topicort (desoximetasone) Cream 0.25%; and Topicort (desoximetasone) Gel 0.05% are indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.
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| dailymed-instance:represent... | |
| dailymed-instance:routeOfAd... | |
| dailymed-instance:name |
Topicort
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