Linked Life Data

Citalopram Hydrobromide (Solution)

Source:http://www4.wiwiss.fu-berlin.de/dailymed/resource/drugs/3936

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SubjectPredicateObjectContext
dailymed-drugs:3936rdf:typehttp://www4.wiwiss.fu-berli...lld:dailymed
dailymed-drugs:3936rdf:typedailymed-instance:drugslld:dailymed
dailymed-drugs:3936rdfs:labelCitalopram Hydrobromide (Solution)lld:dailymed
dailymed-drugs:3936dailymed-instance:supplemen...Medication Guide: 3. How can I watch for and try to prevent suicidal thoughts and actions in myself or a family member?lld:dailymed
dailymed-drugs:3936dailymed-instance:dosageInitial Treatment:<br/>Special Populations:<br/>Treatment of Pregnant Women During the Third Trimester:<br/>Maintenance Treatment:<br/>Discontinuation of Treatment with Citalopram:<br/>Switching Patients To or From a Monoamine Oxidase Inhibitor:lld:dailymed
dailymed-drugs:3936dailymed-instance:clinicalP...Pharmacodynamics:<br/>Pharmacokinetics:<br/>Absorption and Distribution:<br/>Metabolism and Elimination:<br/>Population Subgroups:<br/>Drug-Drug Interactions:<br/>Clinical Efficacy Trials:<br/>Comparison of Clinical Trial Results:lld:dailymed
dailymed-drugs:3936dailymed-instance:activeIng...dailymed-ingredient:Citalop...lld:dailymed
dailymed-drugs:3936dailymed-instance:supplyANIMAL TOXICOLOGY:<br/>Retinal Changes in Rats:<br/>Cardiovascular Changes in Dogs:lld:dailymed
dailymed-drugs:3936dailymed-instance:boxedWarn...BOXED WARNING:lld:dailymed
dailymed-drugs:3936dailymed-instance:activeMoi...dailymed-ingredient:Citalop...lld:dailymed
dailymed-drugs:3936dailymed-instance:inactiveI...dailymed-ingredient:Waterlld:dailymed
dailymed-drugs:3936dailymed-instance:inactiveI...dailymed-ingredient:Propyle...lld:dailymed
dailymed-drugs:3936dailymed-instance:inactiveI...dailymed-ingredient:Methylp...lld:dailymed
dailymed-drugs:3936dailymed-instance:inactiveI...dailymed-ingredient:Propylp...lld:dailymed
dailymed-drugs:3936dailymed-instance:inactiveI...dailymed-ingredient:Non_Cry...lld:dailymed
dailymed-drugs:3936dailymed-instance:inactiveI...dailymed-ingredient:Natural...lld:dailymed
dailymed-drugs:3936dailymed-instance:precautio...General:<br/>Discontinuation of Treatment with Citalopram:<br/>Abnormal Bleeding:<br/>Hyponatremia: Hyponatremia may occur as a result of treatment with SSRIs and SNRIs, including citalopram. In many cases, this hyponatremia appears to be the result of the syndrome of inappropriate antidiuretic hormone secretion (SIADH). Cases with serum sodium lower than 110 mmol/L have been reported. Elderly patients may be at greater risk of developing hyponatremia with SSRIs and SNRIs. Also, patients taking diuretics or who are otherwise volume depleted may be at greater risk (see Geriatric Use). Discontinuation of citalopram should be considered in patients with symptomatic hyponatremia and appropriate medical intervention should be instituted. Signs and symptoms of hyponatremia include headache, difficulty concentrating, memory impairment, confusion, weakness, and unsteadiness, which may lead to falls. Signs and symptoms associated with more severe and/or acute cases have included hallucination, syncope, seizure, coma, respiratory arrest, and death.<br/>Activation of Mania/Hypomania:<br/>Seizures:<br/>Interference with Cognitive and Motor Performance:<br/>Use in Patients with Concomitant Illness:<br/>Information for Patients:<br/>Clinical Worsening and Suicide Risk:<br/>Laboratory Tests:<br/>Drug Interactions: Serotonergic Drugs Based on the mechanism of action of SNRIs and SSRIs including citalopram and the potential for serotonin syndrome, caution is advised when citalopram is coadministered with other drugs that may affect the serotonergic neurotransmitter systems, such as triptans, linezolid (an antibiotic which is a reversible non-selective MAOI), lithium, tramadol, or St. John's Wort . The concomitant use of citalopram with other SSRIs, SNRIs or tryptophan is not recommended . Triptans There have been rare postmarketing reports of serotonin syndrome with use of an SSRI and a triptan. If concomitant treatment of citalopram with a triptan is clinically warranted, careful observation of the patient is advised, particularly during treatment initiation and dose increases .<br/>Carcinogenesis, Mutagenesis, Impairment of Fertility:<br/>Carcinogenesis:<br/>Mutagenesis:<br/>Impairment of Fertility:<br/>Pregnancy:<br/>Pregnancy-Nonteratogenic Effects:<br/>Labor and Delivery:<br/>Nursing Mothers:<br/>Pediatric Use:<br/>Geriatric Use: SSRIs and SNRIs, including citalopram, have been associated with cases of clinically significant hyponatremia in elderly patients, who may be at greater risk for this adverse event .lld:dailymed
dailymed-drugs:3936dailymed-instance:overdosag...Human Experience:<br/>Management of Overdose:lld:dailymed
dailymed-drugs:3936dailymed-instance:genericMe...Citalopram Hydrobromidelld:dailymed
dailymed-drugs:3936dailymed-instance:fullNameCitalopram Hydrobromide (Solution)lld:dailymed
dailymed-drugs:3936dailymed-instance:adverseRe...Adverse Findings Observed in Short-Term, Placebo-Controlled Trials:<br/>Adverse Events Associated with Discontinuation of Treatment:<br/>Adverse Events Occurring at an Incidence of 2% or More Among Citalopram-Treated Patients:<br/>Dose Dependency of Adverse Events:<br/>Male and Female Sexual Dysfunction with SSRIs:<br/>Vital Sign Changes:<br/>Weight Changes:<br/>Laboratory Changes:<br/>ECG Changes:<br/>Other Events Observed During the Premarketing Evaluation of Citalopram Hydrobromide:<br/>Other Events Observed During the Postmarketing Evaluation of Citalopram Hydrobromide.:lld:dailymed
dailymed-drugs:3936dailymed-instance:warningWARNINGS-Clinical Worsening and Suicide Risk:<br/>Clinical Worsening and Suicide Risk:<br/>Screening Patients for Bipolar Disorder: A major depressive episode may be the initial presentation of bipolar disorder. It is generally believed (though not established in controlled trials) that treating such an episode with an antidepressant alone may increase the likelihood of precipitation of a mixed/manic episode in patients at risk for bipolar disorder. Whether any of the symptoms described above represent such a conversion is unknown. However, prior to initiating treatment with an antidepressant, patients with depressive symptoms should be adequately screened to determine if they are at risk for bipolar disorder; such screening shouldinclude a detailed psychiatric history, including a family history of suicide, bipolar disorder, and depression. It should be noted that citalopram is not approved for use in treating bipolar depression.<br/>Potential for Interaction with Monoamine Oxidase Inhibitors:<br/>Serotonin Syndrome: The development of a potentially life-threatening serotonin syndrome may occur with SNRIs and SSRIs, including citalopram treatment, particularly with concomitant use of serotonergic drugs (including triptans) and with drugs which impair metabolism of serotonin (including MAOIs). Serotonin syndrome symptoms may include mental status changes (e.g., agitation, hallucinations, coma), autonomic instability (e.g., tachycardia, labile blood pressure, hyperthermia), neuromuscular aberrations (e.g., hyperreflexia, incoordination) and/or gastrointestinal symptoms (e.g., nausea, vomiting, diarrhea). The concomitant use of citalopram with MAOIs intended to treat depression is contraindicated If concomitant treatment of citalopram with a 5-hydroxytryptamine receptor agonist (triptan) is clinically warranted, careful observation of the patient is advised, particularly during treatment initiation and dose increases . The concomitant use of citalopram with serotonin precursors (such as tryptophan) is not recommended .lld:dailymed
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dailymed-drugs:3936dailymed-instance:nameCitalopram Hydrobromidelld:dailymed
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