Source:http://www4.wiwiss.fu-berlin.de/dailymed/resource/drugs/3917
| Predicate | Object |
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| rdf:type | |
| rdfs:label |
Betamethasone Dipropionate (Lotion)
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| dailymed-instance:dosage |
Betamethasone Dipropionate Lotion USP, 0.05%: Apply a few drops to the affected area and massage lightly until it disappears. Apply twice daily, in the morning and at night. For the most effective and economical use, apply nozzle very close to the affected area and gently squeeze bottle. Betamethasone Dipropionate Lotion USP, 0.05% is not to be used with occlusive dressings. If an infection develops, appropriate antimicrobial therapy should be instituted.
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| dailymed-instance:descripti... |
Betamethasone Dipropionate is a synthetic adrenocorticosteroid, for dermatologic use. It is used as an anti-inflammatory and anti-pruritic agent. Betamethasone Dipropionate is the 17, 21-dipropionate ester of betamethasone, and has the chemical name: 9-fluoro-11��,17,21-trihydroxy-16��-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate. Each gram of Betamethasone Dipropionate Lotion USP, 0.05% w/w contains: 0.64 mg Betamethasone Dipropionate, USP (equivalent to 0.5 mg betamethasone), in a lotion base of Isopropyl alcohol (46.8%), purified water, carbomer 934P, and sodium hydroxide to adjust pH to approximately 4.7.
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| dailymed-instance:clinicalP... |
Topical corticosteroids share anti-inflammatory, anti-pruritic, and vasoconstrictive actions. The mechanism of anti-inflammatory activity of the topical corticosteroids is unclear. Various laboratory methods, including vasoconstrictor assays, are used to compare and predict potencies and/or clinical efficacies of the topical corticosteroid. There is some evidence to suggest that a recognizable correlation exists between vasoconstrictor potency and therapeutic efficacy in man.<br/>Pharmacokinetics: The extent of percutaneous absorption of topical corticosteroids is determined by many factors including the vehicle, the integrity of the epidermal barrier, and the use of occlusive dressings. Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin increase percutaneous absorption. Occlusive dressings substantially increase the percutaneous absorption of topical corticosteroids. Once absorbed through the skin, topical corticosteroids are handled through pharmacokinetic pathways similar to systemically administered corticosteroids. Corticosteroids are bound to plasma proteins in varying degrees. Corticosteroids are metabolized primarily in the liver and are then excreted by the kidneys. Some of the topical corticosteroids and their metabolites are also excreted into the bile.
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| dailymed-instance:activeIng... | |
| dailymed-instance:contraind... |
Topical corticosteroids are contraindicated in those patients with a history of hypersensitivity to any of the components of the preparation.
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| dailymed-instance:supply |
Betamethasone Dipropionate Lotion USP, 0.05%: Available in 20 mL (18.7 g) and 60 mL (56.2 g) plastic bottles. Protect from light. Store in carton until contents are used. Store between 15��-30��C (59��-86��F) For Dermatological Use Only. Not For Ophthalmic Use. Keep Out of the Reach of Children.
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| dailymed-instance:activeMoi... | |
| dailymed-instance:inactiveI... | |
| dailymed-instance:overdosag... |
Topically applied corticosteroids can be absorbed in sufficient amounts to produce systemic effects.
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| dailymed-instance:genericMe... |
Betamethasone Dipropionate
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| dailymed-instance:fullName |
Betamethasone Dipropionate (Lotion)
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| dailymed-instance:adverseRe... |
The following local adverse reactions are reported infrequently with topical corticosteroids when used as recommended. These reactions are listed in an approximate decreasing order of occurrence: Burning, Itching, Irritation, Dryness, Folliculitis, Hypertrichosis, Acneiform Eruptions, Hypopigmentation, Perioral Dermatitis, Allergic contact dermatitis, Maceration of the skin, Secondary infection, Skin Atrophy, Striae, Miliaria.
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| dailymed-instance:indicatio... |
Topical corticosteroid are indicated for relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.
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| dailymed-instance:represent... | |
| dailymed-instance:routeOfAd... | |
| dailymed-instance:name |
Betamethasone Dipropionate
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