Source:http://www4.wiwiss.fu-berlin.de/dailymed/resource/drugs/3900
| Predicate | Object |
|---|---|
| rdf:type | |
| rdfs:label |
Hydrocortisone (Cream)
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| dailymed-instance:dosage |
Topical corticosteroids are generally applied to the affected area as a thin film from two to four times daily depending on the severity of the condition. Occlusive dressings may be used for the management of psoriasis or recalcitrant conditions. If an infection develops, the use of occlusive dressings should be discontinued and appropriate antimicrobial therapy instituted.
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| dailymed-instance:descripti... |
The topical steroids constitute a class of primarily synthetic steroids used as anti-inflammatory and antipruritic agents. Hydrocortisone is a member of this class. Hydrocortisone has the chemical name Pregn-4-ene-3,20-dione, 11,17,21- trihydroxy-, (11��)-. Its molecular formula is CHOand molecular weight 362.47. Structural formula is: Hydrocortisone Cream USP, 1% (Each gram contains 10 mg of Hydrocortisone); 2.5% (Each gram contains 25 mg of Hydrocortisone); in a base containing purified water, propylene glycol, propylene glycol monostearate, mineral oil and lanolin alcohol, isopropyl palmitate, polysorbate 60, cetyl alcohol, sorbitan monostearate, polyoxyl 40 stearate, sorbic acid, methylparaben and propylparaben.
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| dailymed-instance:clinicalP... |
Topical corticosteroids share anti-inflammatory, antipruritic and vasoconstrictive actions. The mechanism of anti-inflammatory activity of topical corticosteroids is unclear. Various laboratory methods, including vasoconstrictor assays, are used to compare and predict potencies and/or clinical efficacies of the topical corticosteroids. There is some evidence to suggest that a recognizable correlation exists between vasoconstrictor potency and therapeutic efficacy in man.<br/>Pharmacokinetics: The extent of percutaneous absorption of topical corticosteroids is determined by many factors including the vehicle, the integrity of the epidermal barrier, and the use of occlusive dressings. Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin increase percutaneous absorption. Occlusive dressings substantially increase the percutaneous absorption of topical corticosteroids. Thus, occlusive dressings may be a valuable therapeutic adjunct for treatment of resistant dermatoses . Once absorbed through the skin, topical corticosteroids are handled through pharmacokinetic pathways similar to systemically administered corticosteroids. Corticosteroids are bound to plasma proteins in varying degrees. Corticosteroids are metabolized primarily in the liver and are then excreted by the kidneys. Some of the topical corticosteroids and their metabolites are also excreted into the bile.
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| dailymed-instance:activeIng... | |
| dailymed-instance:contraind... |
Topical corticosteroids are contraindicated in those patients with a history of hypersensitivity to any of the components of the preparation.
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| dailymed-instance:supply |
Hydrocortisone Cream USP, 1% in28.35 g tubes NDC 51672-3004-2 Hydrocortisone Cream USP, 2.5% in20 g tubes NDC 51672-3003-028.35 g tubes NDC 51672-3003-2 Store at 20��-25��C (68��-77��F)[see USP Controlled Room Temperature]. Protect from freezing.Dispense in tight containers, as specified in the USP.
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| dailymed-instance:genericDr... | |
| dailymed-instance:activeMoi... | |
| dailymed-instance:inactiveI... |
dailymed-ingredient:cetyl_alcohol,
dailymed-ingredient:isopropyl_palmitate,
dailymed-ingredient:lanolin_alcohol,
dailymed-ingredient:methylparaben,
dailymed-ingredient:mineral_oil,
dailymed-ingredient:polyoxyl_40_stearate,
dailymed-ingredient:polysorbate_60,
dailymed-ingredient:propylene_glycol,
dailymed-ingredient:propylene_glycol_monostearate,
dailymed-ingredient:propylparaben,
dailymed-ingredient:sorbic_acid,
dailymed-ingredient:sorbitan_monostearate,
dailymed-ingredient:water
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| dailymed-instance:possibleD... | |
| dailymed-instance:overdosag... |
Topically applied corticosteroids can be absorbed in sufficient amounts to produce systemic effects .
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| dailymed-instance:genericMe... |
Hydrocortisone
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| dailymed-instance:fullName |
Hydrocortisone (Cream)
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| dailymed-instance:adverseRe... |
The following local adverse reactions are reported infrequently with topical corticosteroids, but may occur more frequently with the use of occlusive dressings. These reactions are listed in an approximate decreasing order of occurrence:
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| dailymed-instance:indicatio... |
Topical corticosteroids are indicated for relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.
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| dailymed-instance:represent... | |
| dailymed-instance:routeOfAd... | |
| dailymed-instance:name |
Hydrocortisone
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