Source:http://www4.wiwiss.fu-berlin.de/dailymed/resource/drugs/3766
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| rdf:type | |
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Methimazole (Tablet)
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| dailymed-instance:dosage |
Methimazole is administered orally. It is usually given in
3 equal doses at approximately 8-hour intervals. Adults The initial daily dosage is 15 mg for mild
hyperthyroidism, 30 to 40 mg for moderately severe hyperthyroidism, and 60
mg for severe hyperthyroidism, divided into 3 doses at 8-hour intervals. The
maintenance dosage is 5 to 15 mg daily. Pediatric Initially, the daily dosage is 0.4 mg/kg of body weight divided
into 3 doses and given at 8-hour intervals. The maintenance dosage is approximately
1/2 of the initial dose.
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| dailymed-instance:clinicalP... |
Methimazole inhibits the synthesis of thyroid hormones and
thus is effective in the treatment of hyperthyroidism. The drug does not inactivate
existing thyroxine and triiodothyronine that are stored in the thyroid or
circulating in the blood nor does it interfere with the effectiveness of thyroid
hormones given by mouth or by injection. The actions
and use of methimazole are similar to those of propylthiouracil. On a weight
basis, the drug is at least 10 times as potent as propylthiouracil, but methimazole
may be less consistent in action. Methimazole is readily
absorbed from the gastrointestinal tract. It is metabolized rapidly and requires
frequent administration. Methimazole is excreted in
the urine. In laboratory animals, various regimens that
continuously suppress thyroid function and thereby increase TSH secretion
result in thyroid tissue hypertrophy. Under such conditions, the appearance
of thyroid and pituitary neoplasms has also been reported. Regimens that have
been studied in this regard include antithyroid agents as well as dietary
iodine deficiency, subtotal thyroidectomy, implantation of autonomous thyrotropic
hormone-secreting pituitary tumors, and administration of chemical goitrogens.
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| dailymed-instance:activeIng... | |
| dailymed-instance:supply |
Methimazole Tablets, USP 5 mg white, round, flat-faced, bevelled-edged
tablets with���VM���on one side and scored on the other. They
are available in: Bottles of 100 NDC 0677-1945-01 Methimazole
Tablets, USP 10 mg white, round, flat-faced, bevelled-edged tablets with���XM���on one side and scored on the other. They are available
in: Bottles of 100 NDC 0677-1946-01 Store
at controlled room temperature, 20��- 25��C (68��- 77��F). Dispense
in tight, light-resistant container. DISTRIBUTED BY: UNITED
RESEARCH LABORATORIES, INC. Philadelphia, PA 19124 0677-1946-01
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| dailymed-instance:genericDr... | |
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| dailymed-instance:genericMe... |
methimazole
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| dailymed-instance:fullName |
Methimazole (Tablet)
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| dailymed-instance:adverseRe... |
Major adverse reactions (which occur with much less frequency
than the minor adverse reactions) include inhibition of myelopoiesis (agranulocytosis,
granulocytopenia, and thrombocytopenia), aplastic anemia, drug fever, a lupuslike
syndrome, insulin autoimmune syndrome (which can result in hypoglycemic coma),
hepatitis (jaundice may persist for several weeks after discontinuation of
the drug), periarteritis, and hypoprothrombinemia. Nephritis occurs very rarely. Minor
adverse reactions include skin rash, urticaria, nausea, vomiting, epigastric
distress, arthralgia, paresthesia, loss of taste, abnormal loss of hair, myalgia,
headache, pruritus, drowsiness, neuritis, edema, vertigo, skin pigmentation,
jaundice, sialadenopathy, and lymphadenopathy. It should
be noted that about 10% of patients with untreated hyperthyroidism have leukopenia
(white-blood cell count of less than 4,000/mm), often with relative granulopenia.
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| dailymed-instance:indicatio... |
Methimazole is indicated in the medical treatment of hyperthyroidism.
Long-term therapy may lead to remission of the disease. Methimazole
may be used to ameliorate hyperthyroidism in preparation for subtotal thyroidectomy
or radioactive iodine therapy. Methimazole is also used
when thyroidectomy is contraindicated or not advisable.
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| dailymed-instance:name |
Methimazole
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