Source:http://www4.wiwiss.fu-berlin.de/dailymed/resource/drugs/3756
| Subject | Predicate | Object | Context |
|---|---|---|---|
| dailymed-drugs:3756 | rdf:type | http://www4.wiwiss.fu-berli... | lld:dailymed |
| dailymed-drugs:3756 | rdf:type | dailymed-instance:drugs | lld:dailymed |
| dailymed-drugs:3756 | rdfs:label | Ammonium Lactate (Lotion) | lld:dailymed |
| dailymed-drugs:3756 | dailymed-instance:dosage | Shake well. Apply to the affected areas and rub in thoroughly. Use twice daily or as directed by a physician. | lld:dailymed |
| dailymed-drugs:3756 | dailymed-instance:descripti... | This product specially formulates 12% lactic acid neutralized with ammonium hydroxide, as ammonium lactate to provide a lotion pH of 4.5 - 5.5. It also contains light mineral oil, glyceryl stearate, PEG-100 stearate, propylene glycol, polyoxyl 40 stearate, glycerin, magnesium aluminum silicate, laureth-4, cetyl alcohol, methyl and propyl parabens, methylcellulose, fragrance and water. Lactic acid is a racemic mixture of 2-hydroxypropanoic acid and has the following structuralformula: | lld:dailymed |
| dailymed-drugs:3756 | dailymed-instance:clinicalP... | It is generally accepted that the water content of the stratum corneum is a controlling factor in maintaining skin flexibility. When the stratum corneum contains more than 10% water it remains soft and pliable; however, when the water content drops below 10% the stratum corneum becomes less flexible and rough, and may exhibit scaling and cracking and the underlying skin may become irritatied. Symptomatic relief of dry skin is provided by skin protectants containing hygroscopic substances (humectants) which increase skin moisture. Lactic acid, an��-hydroxy acid, is reported to be one of the most effective naturally occurring humectants in the skin. The��-hydroxy acids (and their salts), in addition to having beneficial effects on dry skin, have also been shown to reduce excessive epidermal keratinization in patients with hyperkeratotic conditions (e.g., ichthyosis).<br/>Pharmacokinetics: The mechanism of action of topically applied neutralized lactic acid is not yet known. | lld:dailymed |
| dailymed-drugs:3756 | dailymed-instance:activeIng... | dailymed-ingredient:Ammoniu... | lld:dailymed |
| dailymed-drugs:3756 | dailymed-instance:contraind... | Known hypersensitivity to any of the label ingredients. | lld:dailymed |
| dailymed-drugs:3756 | dailymed-instance:supply | 225 g plastic bottle and 400 g plastic bottle. Store at controlled room temperature 15�����30��C (59���86��F). | lld:dailymed |
| dailymed-drugs:3756 | dailymed-instance:activeMoi... | dailymed-ingredient:lactic_... | lld:dailymed |
| dailymed-drugs:3756 | dailymed-instance:inactiveI... | dailymed-ingredient:water | lld:dailymed |
| dailymed-drugs:3756 | dailymed-instance:inactiveI... | dailymed-ingredient:glyceri... | lld:dailymed |
| dailymed-drugs:3756 | dailymed-instance:inactiveI... | dailymed-ingredient:magnesi... | lld:dailymed |
| dailymed-drugs:3756 | dailymed-instance:inactiveI... | dailymed-ingredient:methylc... | lld:dailymed |
| dailymed-drugs:3756 | dailymed-instance:inactiveI... | dailymed-ingredient:cetyl_a... | lld:dailymed |
| dailymed-drugs:3756 | dailymed-instance:inactiveI... | dailymed-ingredient:polyoxy... | lld:dailymed |
| dailymed-drugs:3756 | dailymed-instance:inactiveI... | dailymed-ingredient:fragran... | lld:dailymed |
| dailymed-drugs:3756 | dailymed-instance:inactiveI... | dailymed-ingredient:light_m... | lld:dailymed |
| dailymed-drugs:3756 | dailymed-instance:inactiveI... | dailymed-ingredient:glycery... | lld:dailymed |
| dailymed-drugs:3756 | dailymed-instance:inactiveI... | dailymed-ingredient:PEG-100... | lld:dailymed |
| dailymed-drugs:3756 | dailymed-instance:inactiveI... | dailymed-ingredient:laureth... | lld:dailymed |
| dailymed-drugs:3756 | dailymed-instance:inactiveI... | dailymed-ingredient:propyle... | lld:dailymed |
| dailymed-drugs:3756 | dailymed-instance:inactiveI... | dailymed-ingredient:metyl_a... | lld:dailymed |
| dailymed-drugs:3756 | dailymed-instance:overdosag... | The oral administration of ammonium lactate to rats and mice showed this drug to be practically non-toxic LD>15 mL/kg). | lld:dailymed |
| dailymed-drugs:3756 | dailymed-instance:genericMe... | Ammonium Lactate | lld:dailymed |
| dailymed-drugs:3756 | dailymed-instance:fullName | Ammonium Lactate (Lotion) | lld:dailymed |
| dailymed-drugs:3756 | dailymed-instance:adverseRe... | The most frequent adverse experiences in patients with xerosis are transient stinging (1 in 30 patients), burning (1 in 30 patients), erythema (1 in 50 patients) and peeling (1 in 60 patients). Other adverse reactions which occur less frequently are irritation, eczema, petechiae, dryness and hyperpigmentation. Due to the more severe initial skin conditions associated with ichthyosis, there was a higher incidence of transient stinging, burning and erythema (each occurring in 1 in 10 patients). | lld:dailymed |
| dailymed-drugs:3756 | dailymed-instance:indicatio... | Ammonium lactate lotion, 12% is indicated for the treatment of dry, scaly skin (xerosis) and ichthyosis vulgaris and for the temporary relief of itching associated with these conditions. | lld:dailymed |
| dailymed-drugs:3756 | dailymed-instance:represent... | http://www4.wiwiss.fu-berli... | lld:dailymed |
| dailymed-drugs:3756 | dailymed-instance:routeOfAd... | http://www4.wiwiss.fu-berli... | lld:dailymed |
| dailymed-drugs:3756 | dailymed-instance:name | Ammonium Lactate | lld:dailymed |
| http://www4.wiwiss.fu-berli... | dailymed-instance:producesD... | dailymed-drugs:3756 | lld:dailymed |