Source:http://www4.wiwiss.fu-berlin.de/dailymed/resource/drugs/3732
| Predicate | Object |
|---|---|
| rdf:type | |
| rdfs:label |
Lactated Ringers (Injection, Solution)
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| dailymed-instance:dosage |
As directed by a
physician. Dosage is dependent upon the age, weight and clinical
condition of the patient as well as laboratory determinations. Parenteral drug
products should be inspected visually for particulate matter and
discoloration prior to administration whenever solution and container permit. All injections in
VIAFLEX plastic containers are intended for intravenous administration
using sterile equipment. Additives may be
incompatible. Complete information is not available. Those additives
known to be incompatible should not be used. Consult with pharmacist, if
available. If, in the informed judgment of the physician, it is deemed
advisable to introduce additives, use aseptic technique. Mix thoroughly
when additives have been introduced. Do not store solutions containing
additives.
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| dailymed-instance:descripti... |
Lactated Ringer's
Injection, USP is a sterile, nonpyrogenic solution for fluid and
electrolyte replenishment in single dose containers for intravenous
administration. It contains no antimicrobial agents. Composition,
osmolarity, pH, ionic concentration and caloric content are shown in
Table 1. The VIAFLEX plastic
container is fabricated from a specially formulated polyvinyl chloride
(PL 146 Plastic). The amount of water that can permeate from inside the container into the overwrap is insufficient to affect the solution
significantly. Solutions in contact with the plastic container can leach
out certain of its chemical components in very small amounts within the
expiration period, e.g., di-2-ethylhexyl phthalate (DEHP), up to 5 parts
per million. However, the safety of the plastic has been confirmed in
tests in animals according to USP biological tests for plastic
containers as well as by tissue culture toxicity studies.
|
| dailymed-instance:clinicalP... |
Lactated Ringer's
Injection, USP has value as a source of water and electrolytes. It is
capable of inducing diuresis depending on the clinical condition of the
patient. Lactated Ringer's
Injection, USP produces a metabolic alkalinizing effect. Lactate ions
are metabolized ultimately to carbon dioxide and water, which requires
the consumption of hydrogen cations.
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| dailymed-instance:activeIng... | |
| dailymed-instance:contraind... |
None
known
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| dailymed-instance:supply |
Lactated Ringer's
Injection, USP in VIAFLEX plastic container is available as follows: Exposure of
pharmaceutical products to heat should be minimized. Avoid excessive
heat. It is recommended the product be stored at room temperature
(25��C); brief exposure up to 40��C does not adversely affect the product.
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| dailymed-instance:activeMoi... | |
| dailymed-instance:inactiveI... | |
| dailymed-instance:precautio... |
Clinical evaluation
and periodic laboratory determinations are necessary to monitor changes
in fluid balance, electrolyte concentrations, and acid base balance
during prolonged parenteral therapy or whenever the condition of the
patient warrants such evaluation. Lactated Ringer's
Injection, USP must be used with caution. Excess administration may
result in metabolic alkalosis. Caution must be
exercised in the administration of Lactated Ringer's Injection, USP to
patients receiving corticosteroids or corticotropin.<br/>Pregnancy:<br/>Teratogenic
Effects:<br/>Pediatric Use: Safety and
effectiveness of Lactated Ringer's Injection, USP in pediatric
patients have not been established by adequate and well
controlled trials, however, the use of electrolyte solutions in
the pediatric population is referenced in the medical
literature. The warnings, precautions and adverse reactions
identified in the label copy should be observed in the pediatric
population.<br/>Geriatric Use: Clinical studies of Lactated Ringer's Injection, USP did not include
sufficient numbers of subjects aged 65 and over to determine
whether they respond differently from younger subjects. Other
reported clinical experience has not identified differences in
responses between the elderly and younger patients. In general,
dose selection for an elderly patient should be cautious,
usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac
function, and of concomitant disease or drug therapy. Do not
administer unless solution is clear and seal is
intact.
|
| dailymed-instance:genericMe... |
Sodium chloride, potassium chloride, sodium lactate and calcium chloride
|
| dailymed-instance:fullName |
Lactated Ringers (Injection, Solution)
|
| dailymed-instance:adverseRe... |
Allergic reactions
or anaphylactoid symptoms such as localized or generalized urticaria and
pruritis; periorbital, facial, and/or laryngeal edema; coughing,
sneezing, and/or difficulty with breathing have been reported during
administration of Lactated Ringer's Injection, USP. The reporting
frequency of these signs and symptoms is higher in women during
pregnancy. Reactions which may
occur because of the solution or the technique of administration include
febrile response, infection at the site of injection, venous thrombosis or phlebitis extending from the site of injection, extravasation, and
hypervolemia. If an adverse
reaction does occur, discontinue the infusion, evaluate the patient,
institute appropriate therapeutic countermeasures, and save the
remainder of the fluid for examination if deemed necessary.
|
| dailymed-instance:warning |
Lactated Ringer's
Injection, USP should be used with great care, if at all, in patients
with congestive heart failure, severe renal insufficiency, and in
clinical states in which there exists edema with sodium retention. Lactated Ringer's
Injection, USP should be used with great care, if at all, in patients
with hyperkalemia, severe renal failure, and in conditions in which
potassium retention is present. Lactated Ringer's
Injection, USP should be used with great care in patients with metabolic
or respiratory alkalosis. The administration of lactate ions should be
done with great care in those conditions in which there is an increased
level or an impaired utilization of these ions, such as severe hepatic
insufficiency. Lactated Ringer's
Injection, USP should not be administered simultaneously with blood
through the same administration set because of the likelihood of
coagulation. The intravenous
administration of Lactated Ringer's Injection, USP can cause fluid
and/or solute overloading resulting in dilution of serum electrolyte concentrations, overhydration, congested states, or pulmonary edema. The
risk of dilutional states is inversely proportional to the electrolyte
concentrations of the injections. The risk of solute overload causing
congested states with peripheral and pulmonary edema is directly
proportional to the electrolyte concentrations of the injections. In patients with
diminished renal function, administration of Lactated Ringer's
Injection, USP may result in sodium or potassium retention. Lactated Ringer's
Injection, USP is not for use in the treatment of lactic
acidosis.
|
| dailymed-instance:indicatio... |
Lactated Ringer's
Injection, USP is indicated as a source of water and electrolytes or as
an alkalinizing agent.
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| dailymed-instance:represent... | |
| dailymed-instance:routeOfAd... | |
| dailymed-instance:name |
Lactated Ringers
|