Source:http://www4.wiwiss.fu-berlin.de/dailymed/resource/drugs/3284
Predicate | Object |
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rdf:type | |
rdfs:label |
Potassium Chloride in Sodium Chloride (Injection, Solution)
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dailymed-instance:dosage |
As directed by a
physician. Dosage is dependent upon the age, weight and clinical
condition of the patient as well as laboratory determinations. Parenteral drug
products should be inspected visually for particulate matter and
discoloration prior to administration whenever solution and container
permit. Use of final filter is recommended during administration of all
parenteral solutions, where possible. All injections in
VIAFLEX Plus plastic containers are intended for intravenous administration using sterile equipment. Additives may be
incompatible. Complete information is not available. Those additives
known to be incompatible should not be used. Consult with pharmacist, if
available. If, in the informed judgment of the physician, it is deemed
advisable to introduce additives, use aseptic technique. Mix thoroughly
when additives have been introduced. Do not store solutions containingadditives.
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dailymed-instance:descripti... |
Potassium Chloride
in Sodium Chloride Injection, USP is a sterile, nonpyrogenic, solution
for fluid and electrolyte replenishment in a single dose container for
intravenous administration. It contains no antimicrobial agents.
Composition, osmolarity, pH and ionic concentration are shown in Table
1. The VIAFLEX Plus
plastic container is fabricated from a specially formulated polyvinyl
chloride (PL 146 Plastic). VIAFLEX Plus on the container indicates the
presence of a drug additive in a drug vehicle. The VIAFLEX Plus plastic
container system utilizes the same container as the VIAFLEX plastic
container system. The amount of water that can permeate from inside the
container into the overwrap is insufficient to affect the solution
significantly. Solutions in contact with the plastic container can leach
out certain of its chemical components in very small amounts within the expiration period, e.g., di-2-ethylhexyl phthalate (DEHP), up to 5 parts
per million. However, the safety of the plastic hasbeen confirmed in
tests in animals according to USP biological tests for plastic
containers as well as by tissue culture toxicity studies.
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dailymed-instance:clinicalP... |
Potassium Chloride
in Sodium Chloride Injection, USP has value as a source of water and
electrolytes. It is capable of inducing diuresis depending on the
clinical condition of the patient.
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dailymed-instance:activeIng... | |
dailymed-instance:contraind... |
None
known.
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dailymed-instance:supply |
Potassium Chloride
in Sodium Chloride Injection, USP in VIAFLEX Plus Plastic Container is
available as follows: Exposure of
pharmaceutical products to heat should be minimized. Avoid excessive
heat. It is recommended the product be stored at room temperature
(25��C / 77��F); brief exposure up to 40��C
(104��F) does not adversely affect the product.
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dailymed-instance:activeMoi... | |
dailymed-instance:inactiveI... | |
dailymed-instance:precautio... |
Clinical evaluation
and periodic laboratory determinations are necessary to monitor changes
in fluid balance, electrolyte concentrations and acid base balance
during prolonged parenteral therapy or whenever the condition of the
patient warrants such evaluation. Caution must be
exercised in the administration of Potassium Chloride in Sodium Chloride
Injection, USP to patients receiving corticosteroids or
corticotropin.<br/>Pregnancy:<br/>Teratogenic
Effects:<br/>Carcinogenesis and
Mutagenesis and Impairment of Fertility: Studies
with Potassium Chloride in Sodium Chloride Injection, USP have
not been performed to evaluate carcinogenic potential, mutagenic
potential or effects on fertility.<br/>Nursing Mothers: It is not
known whether this drug is excreted in human milk. Because many
drugs are excreted in human milk, caution should be exercised
when Potassium Chloride in Sodium Chloride Injection, USP is
administered to a nursing mother.<br/>Pediatric Use: Safety and
effectiveness of Potassium Chloride in Sodium Chloride
Injection, USP in pediatric patients have not been established
by adequate and well-controlled studies. However, the use of
potassium chloride injection in pediatric patients to treat
potassium deficiency states when oral replacement therapy is not
feasible is referenced in the medical literature. For
patients receiving potassium supplement at greater than
maintenance rates, frequent monitoring of serum potassium levels
and serial EKGs are recommended.<br/>Geriatric Use: Clinical
studies of Potassium Chloride in Sodium Chloride Injection, USP
did not include sufficient numbers of subjects aged 65 and over
to determine whether they respond differently from younger
subjects. Other reported clinical experience has not identified
differences in responses between the elderly and younger
patients. In general, dose selection for an elderly patient
should be cautious, usually starting at the low end of the
dosing range, reflecting the greater frequency of decreased
hepatic, renal, or cardiac function, and of concomitant disease
or drug therapy. This drug
is known to be substantially excreted by the kidney, and the
risk of toxic reactions to this drug may be greater in patients
with impaired renal function. Because elderly patients are more
likely to have decreased renal function, care should be taken in
dose selection, and it may be useful to monitor renal function. Do not
administer unless solution is clear and seal is
intact.
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dailymed-instance:genericMe... |
Potassium Chloride and Sodium Chloride
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dailymed-instance:fullName |
Potassium Chloride in Sodium Chloride (Injection, Solution)
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dailymed-instance:adverseRe... |
Reactions which may
occur because of the solution or the technique of administration include
febrile response, infection at the site of injection, venous thrombosis
or phlebitis extending from the site of injection, extravasation and
hypervolemia. If an adverse
reaction does occur, discontinue the infusion, evaluate the patient,
institute appropriate therapeutic countermeasures and save the remainder
of the fluid for examination if deemed necessary.
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dailymed-instance:warning |
Potassium Chloride
in Sodium Chloride Injection, USP should be used with great care, if at
all, in patients with congestive heart failure, severe renal
insufficiency and in clinical states in which there exists edema with
sodium retention. Potassium Chloride
in Sodium Chloride Injection, USP should be used with great care, if at
all, in patients with hyperkalemia, severe renal failure and in
conditions in which potassium retention is present. The intravenous
administration of Potassium Chloride in Sodium Chloride Injection, USP
can cause fluid and/or solute overloading resulting in dilution of serum
electrolyte concentrations, overhydration, congested states or pulmonary
edema. The risk of dilutional states is inversely proportional to the
electrolyte concentrations of the injection. The risk of solute overload
causing congested states with peripheral and pulmonary edema is directly
proportional to the electrolyte concentrations of the injection. In patients with
diminished renal function, administration of Potassium Chloride in
Sodium Chloride Injection, USP may result in sodium or potassium
retention. Potassium salts
should never be administered by IV push.
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dailymed-instance:indicatio... |
Potassium Chloride
in Sodium Chloride Injection, USP is indicated as a source of water and
electrolytes.
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dailymed-instance:represent... | |
dailymed-instance:routeOfAd... | |
dailymed-instance:name |
Potassium Chloride in Sodium Chloride
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