Source:http://www4.wiwiss.fu-berlin.de/dailymed/resource/drugs/3270
| Predicate | Object |
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| rdf:type | |
| rdfs:label |
Mannitol (Irrigant)
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| dailymed-instance:dosage |
As required for urologic irrigation. 5% Mannitol Irrigation should be administered only by the appropriate transurethral urologic instrumentation. Some additives may be incompatible. Consult with pharmacist.
When introducing additives, use aseptic techniques. Mix thoroughly. Do not store. Solutions should be inspected visually for particulate matter and
discoloration prior to administration, whenever solution and container permits.
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| dailymed-instance:descripti... |
Each 100 mL contains:Mannitol USP 5 gWater for Injection USP qs pH: 5.5 (4.5���7.0)Calculated Osmolarity: 275 mOsmol/literThe formula of the active ingredient is: 5% Mannitol Irrigation is a prediluted, sterile, nonpyrogenic aqueous
solution suitable for urologic irrigation. The solution is approximately isotonic. Mannitol USP is chemically designated D-mannitol (CHO). Mannitol is a hexitol naturally occurring in fruits and vegetables and is produced commercially by the reduction of glucose. The solution contains no antimicrobial or bacteriostatic agents or
added buffers. The plastic container is a copolymer of ethylene and propylene formulated and developed for parenteral drugs. The copolymer contains no plasticizers and exhibits virtually no leachability. The plastic container is also virtually impermeable to vapor transmission and therefore, requires no overwrap to maintain the proper drug concentration. The safety of the plastic container has
been confirmed by biological evaluation procedures. The material passes Class VI testing as specified in the U.S. Pharmacopeia for Biological Tests���Plastic Containers. These tests have shown that the container is nontoxic and biologically inert.
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| dailymed-instance:clinicalP... |
In humans, mannitol is confined to the extracellular space and is
only slightly metabolized. It is rapidly excreted in the urine. When mannitol is absorbed intravascularly, it produces osmotic diuresis and will be excreted by the kidneys. Mannitol is nonelectrolytic and is, therefore, nonconductive, making
it suitable for urologic irrigation during electrosurgical procedures. 5% Mannitol is a nonhemolytic irrigating solution.
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| dailymed-instance:activeIng... | |
| dailymed-instance:contraind... |
5% Mannitol is not for injection. It is contraindicated in patients with anuria.
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| dailymed-instance:supply |
5% Mannitol Irrigation is supplied sterile and nonpyrogenic in PIC���(Plastic Irrigation Containers). The 2000 mL containers are packaged 8 per case and the 4000 mL containers are packaged 4 per case. Exposure of pharmaceutical products to heat should be minimized.
Avoid excessive heat. Protect from freezing. It is recommended that the product be stored at room temperature (25��C); however, brief exposure up to 40��C does not adversely affect the product. Do not warm above 150��F (66��C).
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| dailymed-instance:genericDr... | |
| dailymed-instance:activeMoi... | |
| dailymed-instance:inactiveI... | |
| dailymed-instance:overdosag... |
In the event of dehydration or fluid or solute overload, discontinue the irrigant, evaluate the patient and institute appropriate corrective treatment. See WARNINGS, PRECAUTIONS, and ADVERSE REACTIONS.
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| dailymed-instance:genericMe... |
Mannitol
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| dailymed-instance:fullName |
Mannitol (Irrigant)
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| dailymed-instance:adverseRe... |
Occasional adverse reactions to intravenous mannitol infusions have been reported. These include fluid and electrolyte disturbances, such as acidosis, electrolyte loss, marked diuresis, urinary retention, edema, dryness of the mouth, thirst and dehydration, cardiovascular/pulmonary disorders such as pulmonary congestion, hypotension, tachycardia, angina-like
pain, and thrombophlebitis, and other general reactions such as blurred vision, convulsions, nausea, vomiting, rhinitis, chills, vertigo, backache, and urticaria. If an adverse reaction does occur, discontinue administration of the irrigant, evaluate the patient, institute appropriate therapeutic countermeasures and save the remainder of the fluid for examination, if deemed necessary.
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| dailymed-instance:indicatio... |
5% Mannitol is indicated for use as a urologic irrigation fluid for transurethral prostatic resection and other transurethral surgical procedures.
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| dailymed-instance:represent... | |
| dailymed-instance:routeOfAd... | |
| dailymed-instance:name |
Mannitol
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