Source:http://www4.wiwiss.fu-berlin.de/dailymed/resource/drugs/3191
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Kionex (Suspension)
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| dailymed-instance:dosage |
The average daily adult dose is 15 g (60 mL) to 60 g (240 mL) of suspension. This is best provided by administering 15 g (60 mL) of Kionex Suspension one to four times daily. Each 60 mL of Kionex Suspension contains 1500 mg (65 mEq) of sodium. Since the in vivo efficiency of sodium-potassium exchange resins is approximately 33%, about one-third ofthe resin's actual sodium content is being delivered to the body. In smaller children and infants, lower doses should be employed by using as a guide a rate of 1 mEq of potassium per gram of resin as the basis for calculation. Kionex Suspension may be introduced into the stomach through a plastic tube and, if desired, given with a diet appropriate for a patient in renal failure. Kionex Suspension may also be given, although with less effective results, as an enema consisting (for adults) of 30 g (120 mL) to 50 g (200 mL) every six hours. The enema should be retained as long as possible and followed by a cleansing enema. After an initial cleansing enema, a soft, large size (French 28) rubber tube is inserted into the rectum for a distance of about 20 cm, with the tip well into the sigmoid colon, and taped into place. The suspension is introduced at body temperature by gravity. The suspension is flushed with 50 or 100 mL offluid, following which the tube is clamped and left in place. If back leakage occurs, the hips are elevated on pillows or a knee-chest position is taken temporarily. The suspension is kept in the sigmoid colon for several hours, if possible. Then the colon is irrigated with nonsodium containing solution at body temperature in order to remove the resin. Two quarts of flushing solution may be necessary. The returns are drained constantly through a Y tube connection. Particular attention should be paid to thecleansing enema, because sorbitol is present in the vehicle. The intensity and duration of therapy depend upon the severity and resistance of hyperkalemia.
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| dailymed-instance:descripti... |
Kionex (Sodium Polystyrene Sulfonate Suspension, USP) can be administered orally or in an enema. It is a raspberry-flavored suspension containing 15 grams of cation-exchange resin (Sodium Polystyrene Sulfonate, USP); 21.5 mL of Sorbitol Solution USP (equivalent to approximately 19.3 grams of Sorbitol); 0.12 mL (0.2%) of Alcohol per 60 mL of suspension. Also contains Purified Water USP, Propylene Glycol USP, Magnesium Aluminum Silicate NF, Xanthan Gum NF, Sodium Saccharin USP, Sorbic Acid NF, Methylparaben NF, Propylparaben NF, and Flavor. Sodium polystyrene sulfonate is a benzene, diethenyl-, polymer with ethenylbenzene, sulfonated, sodium salt and has the following structural formula: The sodium content of the suspension is 1500 mg (65 mEq) per 60 mL. It is a brown, slightly viscous suspension with an in vitro exchange capacity of approximately 3.1 mEq (in vivo approximately 1 mEq) of potassium per 4 mL (1 gram) of suspension.
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| dailymed-instance:clinicalP... |
As the resin passes along the intestine or is retained in the colon after administration by enema, the sodium ions are partially released and are replaced by potassium ions. For the most part, this action occurs in the large intestine, which excretes potassium ions to a greater degree than does the small intestine. The efficiency of this process is limited and unpredictably variable. It commonly approximates the order of 33%, but the range is so large that definitive indices of electrolyte balance mustbe clearly monitored. Metabolic data are unavailable.
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| dailymed-instance:activeIng... | |
| dailymed-instance:contraind... |
Kionex Suspension is contraindicated in patients with hypokalemia or those patients who are hypersensitive to it.
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| dailymed-instance:supply |
Kionex Suspension is a light brown, raspberry-flavored suspension supplied as follows: Kionex Suspension (Sodium Polystyrene Sulfonate Suspension, USP) SHAKE WELL BEFORE USING. Store at 20��to 25��C (68��to 77��F) [see USP Controlled Room Temperature] Kionex Suspension should not be heated for to do so may alter the exchange properties of the resin. Dispense in a tight container, as defined in the USP. If repackaging into other containers, store in refrigerator and use within 14 days of packaging.
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| dailymed-instance:activeMoi... | |
| dailymed-instance:inactiveI... |
dailymed-ingredient:Alcohol,
dailymed-ingredient:Flavor,
dailymed-ingredient:Magnesuim_Aluminum_Silicate,
dailymed-ingredient:Methylparaben,
dailymed-ingredient:Propylene_Glycol,
dailymed-ingredient:Propylparaben,
dailymed-ingredient:Sodium_Saccharin,
dailymed-ingredient:Sorbic_Acid,
dailymed-ingredient:Sorbitol_Solution,
dailymed-ingredient:Water,
dailymed-ingredient:Xanthan_Gum
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| dailymed-instance:genericMe... |
Sodium Polystyrene Sulfonate
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| dailymed-instance:fullName |
Kionex (Suspension)
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| dailymed-instance:adverseRe... |
Kionex Suspension may cause some degree of gastric irritation. Anorexia, nausea, vomiting, and constipation may occur especially if high doses are given. Also, hypokalemia, hypocalcemia, and significant sodium retention may occur. Occasionally diarrhea develops. Large doses in elderly individuals may cause fecal impaction . This effect may be obviated through usage of the resin in enemas as described under DOSAGE AND ADMINISTRATION. Rare instances of colonic necrosis have been reported. Intestinal obstruction due to concretions of aluminum hydroxide, when used in combination with sodium polystyrene sulfonate, has been reported.
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| dailymed-instance:indicatio... |
Kionex Suspension is indicated for the treatment of hyperkalemia.
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| dailymed-instance:represent... | |
| dailymed-instance:routeOfAd... | |
| dailymed-instance:name |
Kionex
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