Source:http://www4.wiwiss.fu-berlin.de/dailymed/resource/drugs/3170
Predicate | Object |
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rdf:type | |
rdfs:label |
Polysporin (Ointment)
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dailymed-instance:dosage |
Apply the ointment every 3 or 4 hours for 7 to 10 days,
depending on the severity of the infection.
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dailymed-instance:descripti... |
POLYSPORIN Ophthalmic Ointment (bacitracin zinc and polymyxin
B sulfate ophthalmic ointment) is a sterile antimicrobial ointment for ophthalmic
use. Each gram contains: bacitracin zinc equivalent to 500 bacitracin units,
polymyxin B sulfate equivalent to 10,000 polymyxin B units, and white petrolatum,
q.s. Bacitracin zinc is the zinc salt of bacitracin,
a mixture of related cyclic polypeptides (mainly bacitracin A) produced by
the growth of an organism of the licheniformis group of Bacillus subtilis var
Tracy. It has a potency of not less than 40 bacitracin units per mg. The structural
formula for bacitracin A is: Polymyxin B sulfate is the sulfate
salt of polymyxin Band Bwhich are produced by the
growth of Bacillus polymyxa (Prazmowski)
Migula (Fam. Bacillaceae). It has a potency of not less than 6,000 polymyxin
B units per mg, calculated on an anhydrous basis. The structural formulae
are:
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dailymed-instance:clinicalP... |
A wide range of antibacterial action is provided by the
overlapping spectra of bacitracin and polymyxin B sulfate. Bacitracin
is bactericidal for a variety of gram-positive and gram-negative organisms.
It interferes with bacterial cell wall synthesis by inhibition of the regeneration
of phospholipid receptors involved in peptidoglycan synthesis. Polymyxin
B is bactericidal for a variety of gram-negative organisms. It increases the
permeability of the bacterial cell membrane by interacting with the phospholipid
components of the membrane. Microbiology: Bacitracin
zinc and polymyxin B sulfate together are considered active against the following
microorganisms: Staphylococcus aureus,
streptococci including Streptococcus pneumoniae, Escherichia coli, Haemophilus influenzae, Klebsiella/Enterobacter species, Neisseria species,
and Pseudomonas aeruginosa. The product
does not provide adequate coverage against Serratia
marcescens.
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dailymed-instance:activeIng... | |
dailymed-instance:contraind... |
POLYSPORIN Ophthalmic Ointment is contraindicated in individuals
who have shown hypersensitivity to any of its components.
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dailymed-instance:supply |
POLYSPORIN Ophthalmic Ointment (bacitracin zinc and polymyxin
B sulfate ophthalmic ointment, USP) is available as a tube of 1/8 oz (3.5
g) with ophthalmic tip (NDC 61570-049-35). Rx Only Store at 15��to 25��C (59��to 77��F). April
1995 Distributed by: Monarch Pharmaceuticals, Inc.,
Bristol, TN 37620
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dailymed-instance:activeMoi... | |
dailymed-instance:precautio... |
General: As with other antibiotic preparations, prolonged use of
POLYSPORIN Ophthalmic Ointment may result in overgrowth of nonsusceptible
organisms including fungi. If superinfection occurs, appropriate measures
should be initiated. Bacterial resistance to POLYSPORIN
Ophthalmic Ointment may also develop. If purulent discharge, inflammation,
or pain become aggravated, the patient should discontinue use of the medication
and consult a physician. There have been reports of
bacterial keratitis associated with the use of topical ophthalmic products
in multiple-dose containers which have been inadvertently contaminated by
patients, most of whom had a concurrent corneal disease or a disruption of
the ocular epithelial surface (see PRECAUTIONS:
Information for Patients). Allergic
cross-reactions may occur which could prevent the use of any or all of the
following antibiotics for the treatment of future infections: kanamycin, paromomycin,
streptomycin, and possibly gentamicin.<br/>Information for Patients: Patients should be instructed to avoid allowing the tip
of the dispensing container to contact the eye, eyelid, fingers, or any other
surface. The use of this product by more than one person may spread infection. Patients should also be instructed that ocular products,
if handled improperly, can become contaminated by common bacteria known to
cause ocular infections. Serious damage to the eye and subsequent loss of
vision may result from using contaminated products . If
the condition persists or gets worse, or if a rash or other allergic reaction
develops, the patient should be advised to stop use and consult a physician.
Do not use this product if you are allergic to any of the listed ingredients. Keep tightly closed when not in use. Keep out of reach
of children.<br/>Carcinogenesis, Mutagenesis, Impairment of Fertility: Long-term studies in animals to evaluate carcinogenic or
mutagenic potential have not been conducted with polymyxin B sulfate or bacitracin.
Polymyxin B has been reported to impair the motility of equine sperm, but
its effects on male or female fertility are unknown. No adverse effects on
male or female fertility, litter size, or survival were observed in rabbits
given bacitracin zinc 100 gm/ton of diet.<br/>Pregnancy:<br/>Teratogenic Effects: Pregnancy Category C. Animal reproduction studies have not
been conducted with polymyxin B sulfate or bacitracin. It is also not known
whether POLYSPORIN Ophthalmic Ointment can cause fetal harm when administered
to a pregnant woman or can affect reproduction capacity. POLYSPORIN Ophthalmic
Ointment should be given to a pregnant woman only if clearly needed.<br/>Nursing Mothers: It is not known whether this drug is excreted in human milk.
Because many drugs are excreted in human milk, caution should be exercised
when POLYSPORIN Ophthalmic Ointment is administered to a nursing woman.<br/>Pediatric Use: Safety and effectiveness in pediatric patients have not
been established.
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dailymed-instance:genericMe... |
bacitracin zinc and polymyxin B sulfate
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dailymed-instance:fullName |
Polysporin (Ointment)
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dailymed-instance:adverseRe... |
Adverse reactions have occurred with the anti-infective
components of POLYSPORIN Ophthalmic Ointment. The exact incidence is not known.
Reactions occurring most often are allergic sensitization reactions including
itching, swelling, and conjunctival erythema . More serious hypersensitivity
reactions, including anaphylaxis, have been reported rarely. Local
irritation on installation has also been reported.
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dailymed-instance:warning |
NOT FOR INJECTION INTO THE EYE. POLYSPORIN Ophthalmic Ointment
should never be directly introduced into the anterior chamber of the eye.
Ophthalmic ointments may retard corneal wound healing. Topical
antibiotics may cause cutaneous sensitization. A precise incidence of hypersensitivity
reactions (primarily skin rash) due to topical antibiotics is not known. The
manifestations of sensitization to topical antibiotics are usually itching,
reddening, and edema of the conjunctiva and eyelid. A sensitization reaction
may manifest simply as a failure to heal. During long-term use of topical
antibiotic products, periodic examination for such signs is advisable, and
the patient should be told to discontinuethe product if they are observed.
Symptoms usually subside quickly on withdrawing the medication. Application
of products containing these ingredients should be avoided for the patient
thereafter (see PRECAUTIONS:
General).
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dailymed-instance:indicatio... |
POLYSPORIN Ophthalmic Ointment is indicated for the topical
treatment of superficial infections of the external eye and its adnexa caused
by susceptible bacteria. Such infections encompass conjunctivitis, keratitis
and keratoconjunctivitis, blepharitis and blepharoconjunctivitis.
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dailymed-instance:represent... | |
dailymed-instance:routeOfAd... | |
dailymed-instance:name |
Polysporin
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