Source:http://www4.wiwiss.fu-berlin.de/dailymed/resource/drugs/3099
| Predicate | Object |
|---|---|
| rdf:type | |
| rdfs:label |
Chloromycetin (Solution)
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| dailymed-instance:dosage |
Instill 2 or 3 drops into the affected ear three times daily.
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| dailymed-instance:descripti... |
Each milliliter of Chloromycetin Otic contains 5 mg (0.5%)
chloramphenicol in propylene glycol. Sterile. The chemical
names for chloramphenicol are: Chloramphenicol has the following empirical and structural
formulas:
|
| dailymed-instance:clinicalP... |
Chloramphenicol is a broad-spectrum antibiotic originally
isolated from Streptomyces venezuelae.
It is primarily bacteriostatic and acts by inhibition of protein synthesis
by interfering with the transfer of activated amino acids from soluble RNA
to ribosomes. Development of resistance to chloramphenicol can be regarded
as minimal for staphylococci and many other species of bacteria.
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| dailymed-instance:activeIng... | |
| dailymed-instance:contraind... |
This product is contraindicated in persons sensitive to
any of its components. Perforated tympanic membrane
is considered a contraindication to the use of any medication in the external
ear canal.
|
| dailymed-instance:supply |
NDC 61570-331-31 Chloromycetin (chloramphenicol)
Otic is supplied in 15 mL vials with droppers.
|
| dailymed-instance:genericDr... | |
| dailymed-instance:boxedWarn... |
WARNING Bone
marrow hypoplasia including aplastic anemia and death has been reported following
local application of chloramphenicol. Chloramphenicol should not be used when
less potentially dangerous agents would be expected to provide effective treatment.
|
| dailymed-instance:activeMoi... | |
| dailymed-instance:inactiveI... | |
| dailymed-instance:precautio... |
The prolonged use of antibiotics may occasionally result
in overgrowth of nonsusceptible organisms, including fungi. If new infections
appear during medication, the drug should be discontinued and appropriate
measures should be taken. In all serious infections,
the topical use of chloramphenicol should be supplemented by appropriate systemic
medication. The possibility of the occurrence of ototoxicity
must be considered if this product is allowed to enter the middle ear.
|
| dailymed-instance:genericMe... |
chloramphenicol
|
| dailymed-instance:fullName |
Chloromycetin (Solution)
|
| dailymed-instance:adverseRe... |
Signs of local irritation with subjective symptoms of itching
or burning, angioneurotic edema, urticaria, vesicular and maculopapular dermatitis
have been reported in patients sensitive to chloramphenicol and are causes
for discontinuing the medication. Similar sensitivity reactions to other materials
in topical preparations may also occur. Blood dyscrasias have been reported
in association with the use of chloramphenicol (see WARNINGS).
|
| dailymed-instance:warning |
SEE BOXED WARNING. Discontinue promptly
if sensitization or irritation occurs.
|
| dailymed-instance:indicatio... |
Chloromycetin (chloramphenicol) Otic is indicated for the
treatment of surface infections of the external auditory canal caused by susceptible
strains of various gram-positive and gram-negative organisms including: Staphylococcus aureus, Escherichia coli, Hemophilus influenzae,
Pseudomonas aeruginosa, Aerobacter aerogenes, Klebsiella pneumoniae and Proteus species. Deeper
infections should be treated with appropriate systemic antibiotics.
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| dailymed-instance:represent... | |
| dailymed-instance:routeOfAd... | |
| dailymed-instance:name |
Chloromycetin
|