Source:http://www4.wiwiss.fu-berlin.de/dailymed/resource/drugs/3098
| Predicate | Object |
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| rdf:type | |
| rdfs:label |
Diflorasone Diacetate (Ointment)
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| dailymed-instance:dosage |
Diflorasone diacetate ointment should be applied to the affected area as a thin film from one to three times daily depending on the severity or resistant nature of the condition. Occlusive dressings may be used for the management of psoriasis or recalcitrant conditions. If an infection develops, the use of occlusive dressings should be discontinued and appropriate antimicrobial therapy initiated.
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| dailymed-instance:descripti... |
Each gram of diflorasone diacetate ointment contains 0.5 mg diflorasone diacetate in an ointment base. Chemically, diflorasone diacetate is 6��,9-difluoro-11��,17,21-trihydroxy-16��-methylpregna-1,4-diene-3,20-dione 17,21-diacetate. The structural formula is represented below: Each gram of diflorasone diacetate ointment contains 0.5 mg diflorasone diacetate in an ointment base of propylene glycol, glyceryl monostearate and white petrolatum.
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| dailymed-instance:clinicalP... |
Topical corticosteroids share anti-inflammatory, antipruritic and vasoconstrictive actions. The mechanism of anti-inflammatory activity of the topical corticosteroids is unclear. Various laboratory methods, including vasoconstrictor assays, are used to compare and predict potencies and/or clinical efficacies of the topical corticosteroids. There is some evidence tosuggest that a recognizable correlation exists between vasoconstrictor potency and therapeutic efficacy in man.<br/>Pharmacokinetics: The extent of percutaneous absorption of topical corticosteroids is determined by many factors including the vehicle, the integrity of the epidermal barrier, and the use of occlusive dressings. Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin increase percutaneous absorption. Occlusive dressings substantially increase the percutaneous absorption of topical corticosteroids. Thus, occlusive dressings may be a valuable therapeutic adjunct for treatment of resistant dermatoses. Once absorbed through the skin, topical corticosteroids are handled through pharmacokinetic pathways similar to systemically administered corticosteroids. Corticosteroids are bound to plasma proteins in varying degrees. They are metabolized primarily in the liver and are then excreted by the kidneys. Some of the topical corticosteroids and their metabolites are also excreted into the bile.
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| dailymed-instance:activeIng... | |
| dailymed-instance:contraind... |
Topical steroids are contraindicated in those patients with a history of hypersensitivity to any of the components of the preparation.
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| dailymed-instance:supply |
Diflorasone Diacetate Ointment USP, 0.05% is available in 15 gram (NDC 51672-1295-1), 30 gram (NDC 51672-1295-2) and 60 gram (NDC 51672-1295-3) tubes. Store at 20��-25��C (68��-77��F) [see USP Controlled Room Temperature].
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| dailymed-instance:activeMoi... | |
| dailymed-instance:inactiveI... | |
| dailymed-instance:overdosag... |
Topically applied corticosteroids can be absorbed in sufficient amounts to produce systemic effects.
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| dailymed-instance:genericMe... |
Diflorasone Diacetate
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| dailymed-instance:fullName |
Diflorasone Diacetate (Ointment)
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| dailymed-instance:adverseRe... |
The following local adverse reactions have been reported with topical corticosteroids, but may occur more frequently with the use of occlusive dressings. These reactions are listed in approximate decreasing order of occurrence:
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| dailymed-instance:indicatio... |
Topical corticosteroids are indicated for relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.
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| dailymed-instance:represent... | |
| dailymed-instance:routeOfAd... | |
| dailymed-instance:name |
Diflorasone Diacetate
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