Source:http://www4.wiwiss.fu-berlin.de/dailymed/resource/drugs/3084
| Predicate | Object |
|---|---|
| rdf:type | |
| rdfs:label |
Diflorasone Diacetate (Cream)
|
| dailymed-instance:dosage |
Diflorasone diacetate cream USP, 0.05% should be applied to the affected area twice daily.
|
| dailymed-instance:descripti... |
Diflorasone diacetate cream USP, 0.05% contains the active compound diflorasone diacetate, a synthetic corticosteroid for topical dermatological use. Chemically, diflorasone diacetate is 6��, 9��-difluoro-11��,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione 17,21 diacetate, with the empirical formula CHFO, a molecular weight of 494.5, and the following structural formula: Each gram of diflorasone diacetate cream USP, 0.05% contains 0.5 mg diflorasone diacetate in a cream base consisting of purified water, citric acid, mineral oil, lanolin alcohol, isopropyl myristate, cetyl alcohol, glyceryl stearate/PEG 100 stearate, polysorbate 60, sorbitan monostearate, polyoxyl 40 stearate, butylated hydroxytoluene, vegetable oil, propylene glycol, monobasic sodium phosphate.
|
| dailymed-instance:clinicalP... |
Like other topical corticosteroids, diflorasone diacetate has anti-inflammatory, anti-pruritic, and vasoconstrictive actions. The mechanism of the anti-inflammatory activity of the topical corticosteroids, in general, is unclear. However, corticosteroids are thought to act by the induction of phospholipase Ainhibitory proteins collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A.<br/>Pharmacokinetics: The extent of percutaneous absorption of topical corticosteroids is determined by many factors including the vehicle and the integrity of the epidermal barrier. Occlusive dressings with hydrocortisone for up to 24 hours have not been demonstrated to increase penetration; however, occlusion of hydrocortisone for 96 hours markedly enhances penetration. Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin may increase percutaneous absorption. Studies performed with diflorasone diacetate cream indicate that it is in the high range of potency as compared with other topical corticosteroids.
|
| dailymed-instance:activeIng... | |
| dailymed-instance:contraind... |
Diflorasone diacetate cream USP is contraindicated in those patients with a history of hypersensitivity to any of the components of the preparation.
|
| dailymed-instance:supply |
Diflorasone diacetate cream USP, 0.05% is available in 15 g (NDC 51672-1296-1), 30 g (NDC 51672-1296-2) and 60 g (NDC 51672-1296-3) tubes. Store at 20��-25��C (68��-77��F) [see USP Controlled Room Temperature]. Keep tightly closed.
|
| dailymed-instance:activeMoi... | |
| dailymed-instance:inactiveI... |
dailymed-ingredient:butylated_hydroxytoluene,
dailymed-ingredient:cetyl_alcohol,
dailymed-ingredient:citric_acid,
dailymed-ingredient:glyceryl_stearate/PEG_100_stearate,
dailymed-ingredient:isopropyl_myristate,
dailymed-ingredient:lanolin_alcohol,
dailymed-ingredient:mineral_oil,
dailymed-ingredient:monobasic_sodium_phosphate,
dailymed-ingredient:polyoxyl_40_stearate,
dailymed-ingredient:polysorbate_60,
dailymed-ingredient:propylene_glycol,
dailymed-ingredient:sorbitan_monostearate,
dailymed-ingredient:vegetable_oil,
dailymed-ingredient:water
|
| dailymed-instance:overdosag... |
Topically applied diflorasone diacetate cream USP, 0.05% can be absorbed in sufficient amounts to produce systemic effects .
|
| dailymed-instance:genericMe... |
Diflorasone Diacetate
|
| dailymed-instance:fullName |
Diflorasone Diacetate (Cream)
|
| dailymed-instance:adverseRe... |
The following local adverse reactions have been reported infrequently with other topical corticosteroids, and they may occur more frequently with the use of occlusive dressings, especially with higher potency corticosteroids. These reactions are listed in an approximate decreasing order of occurrence: burning, itching, irritation, dryness, folliculitis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, secondary infections, skin atrophy, striae, and miliaria.
|
| dailymed-instance:represent... | |
| dailymed-instance:routeOfAd... | |
| dailymed-instance:name |
Diflorasone Diacetate
|