Source:http://www4.wiwiss.fu-berlin.de/dailymed/resource/drugs/2861
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| rdf:type | |
| rdfs:label |
Metronidazole (Gel)
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| dailymed-instance:dosage |
Apply and rub in a thin film of metronidazole topical gel twice daily, morning and evening, to entire affected areas after washing. Areas to be treated should be cleansed before application of metronidazole topical gel. Patients may use cosmetics after application of metronidazole topical gel.
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| dailymed-instance:descripti... |
Metronidazole Topical Gel USP 0.75% contains metronidazole, USP, at a concentration of 7.5 mg per gram (0.75%) in a gel consisting of purified water, methylparaben, propylparaben, propylene glycol, carbomer 940, sodium hydroxide, and edetate disodium. Metronidazole is classified therapeutically as an antiprotozoal and anti-bacterial agent. Chemically, metronidazole is named 2-methyl-5-nitroimidazole-1-ethanol and has the following structure:
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| dailymed-instance:clinicalP... |
Bioavailability studies on the topical administration of 1 gram of metronidazole topical gel (7.5 mg of metronidazole) to the face of 10 rosacea patients showed a maximum serum concentration of 66 nanograms per milliliter in one patient. This concentration is approximately 100 times less than concentrations afforded by a single 250 mg oral tablet. The serum metronidazole concentrations were below the detectable limits of the assay at the majority of time points in all patients. Three of the patients had no detectable serum concentrations of metronidazole at any time point. The mean dose of gel applied during clinical studies was 600 mg which represents 4.5 mg of metronidazole per application. Therefore, under normal usage levels, the formulation affords minimal serum concentrations of metronidazole. The mechanisms by which metronidazole topical gel acts in the treatment of rosacea are unknown, but appear to include an anti-inflammatory effect.
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| dailymed-instance:activeIng... | |
| dailymed-instance:contraind... |
Metronidazole topical gel is contraindicated in individuals with a history of hypersensitivity to metronidazole, parabens, or other ingredients of the formulation.
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| dailymed-instance:supply |
Metronidazole Topical Gel USP 0.75% is supplied as follows: 45 gram tube NDC 0168-0275-45 Store at 20��-25��C (68��-77��F)[see USP Controlled Room Temperature]. E. FOUGERA&CO.a division of Altana Inc.MELVILLE, NEW YORK 11747 I2275R1/06#87
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| dailymed-instance:genericDr... | |
| dailymed-instance:activeMoi... | |
| dailymed-instance:inactiveI... | |
| dailymed-instance:genericMe... |
Metronidazole
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| dailymed-instance:fullName |
Metronidazole (Gel)
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| dailymed-instance:adverseRe... |
The following adverse experiences have been reported with the topical use of metronidazole: burning, skin irritation, dryness, transient redness, metallic taste, tingling or numbness of extremities and nausea.
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| dailymed-instance:indicatio... |
Metronidazole topical gel is indicated for topical application in the treatment of inflammatory papules and pustules of rosacea.
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| dailymed-instance:name |
Metronidazole
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