Source:http://www4.wiwiss.fu-berlin.de/dailymed/resource/drugs/2654
| Predicate | Object |
|---|---|
| rdf:type | |
| rdfs:label |
Psorcon (Cream)
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| dailymed-instance:dosage |
psorcon (diflorasone diacetate cream) should be applied to the affected area twice daily.
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| dailymed-instance:descripti... |
psorcon' (diflorasone diacetate cream) contains the active compound diflorasone diacetate, a synthetic corticosteroid for topical dermatological use. Chemically, diflorasone diacetate is 6��,9��-difluoro-11��,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione 17,21 diacetate, with the empirical formula CHFO, a molecular weight of 494.5, and the following structural formula: Each gram of psorcon Cream contains 0.5 mg diflorasone diacetate in a cream base consisting of purified water USP, propylene glycol USP, mineral oil (and) lanolin alcohol, glyceryl stearate SE (nonionic), isopropyl myristate NF, polysorbate 60 NF, sorbitan monostearate NF, polyoxyl 40 stearate NF, cetyl alcohol NF, monobasic sodium phosphate USP, vegetable oil, monoglyceride citrate, BHT and citric acid.
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| dailymed-instance:clinicalP... |
Like other topical corticosteroids, diflorasone diacetate has anti-inflammatory, anti-pruritic, and vasoconstrictive actions. The mechanism of the anti-inflammatory activity of the topical corticosteroids, in general, is unclear. However, corticosteroids are thought to act by the induction of phospholipase Ainhibitory proteins collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A.<br/>Pharmacokinetics: The extent of percutaneous absorption of topical corticosteroids is determined by many factors including the vehicle and the integrity of the epidermal barrier. Occlusive dressings with hydrocortisone for up to 24 hours have not been demonstrated to increase penetration; however, occlusion of hydrocortisone for 96 hours markedly enhances penetration. Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin may increase percutaneous absorption. Studies performed with psorcon Cream indicate that it is in the high range of potency as compared with other topical corticosteroids.
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| dailymed-instance:activeIng... | |
| dailymed-instance:contraind... |
psorcon (diflorasone diacetate cream) is contraindicated in those patients with a history of hypersensitivity to any of the components of the preparation.
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| dailymed-instance:supply |
psorcon Cream 0.05% is available in the following size tubes: 60 gram NDC 0066-0069-60 Store at or below 25��C (77��F).
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| dailymed-instance:activeMoi... | |
| dailymed-instance:inactiveI... |
dailymed-ingredient:BHT,
dailymed-ingredient:cetyl_alcohol,
dailymed-ingredient:citric_acid,
dailymed-ingredient:glyceryl_stearate_SE_(nonionic),
dailymed-ingredient:isopropyl_myristate,
dailymed-ingredient:lanolin_alcohol,
dailymed-ingredient:mineral_oil,
dailymed-ingredient:monobasic_sodium_phosphate,
dailymed-ingredient:monoglyceride_citrate,
dailymed-ingredient:polyoxyl_40_stearate,
dailymed-ingredient:polysorbate_60,
dailymed-ingredient:propylene_glycol,
dailymed-ingredient:sorbitan_monostearate,
dailymed-ingredient:vegetable_oil,
dailymed-ingredient:water
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| dailymed-instance:overdosag... |
Topically applied psorcon (diflorasone diacetate cream) can be absorbed in sufficient amounts to produce systemic effects .
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| dailymed-instance:genericMe... |
diflorasone diacetate
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| dailymed-instance:fullName |
Psorcon (Cream)
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| dailymed-instance:adverseRe... |
The following local adverse reactions have been reported infrequently with other topical corticosteroids, and they may occur more frequently with the use of occlusive dressings, especially with higher potency corticosteroids. These reactions are listed in an approximate decreasing order of occurrence: burning, itching, irritation, dryness, folliculitis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, secondary infections, skin atrophy, striae, and miliaria.
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| dailymed-instance:represent... | |
| dailymed-instance:routeOfAd... | |
| dailymed-instance:name |
Psorcon
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