Source:http://www4.wiwiss.fu-berlin.de/dailymed/resource/drugs/2292
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Potassium Chloride in Dextrose and Sodium Chloride (Injection, Solution)
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| dailymed-instance:dosage |
As directed by a physician. Dosage is dependent upon the age, weight and clinical condition of the patient as well as laboratory
determinations. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration whenever
solution and container permit. Use of a final filter is recommended during administration of all parenteral solutions, where possible. All injections in VIAFLEX Plus plastic containers are intended for intravenous administration using sterile equipment. Additives may be incompatible. Complete information is not available. Those additives known to be incompatible should not be used.
Consult with pharmacist, if available. If, in the informed judgment of the physician, it is deemed advisable to introduce additives, use aseptic technique. Mix thoroughly when additives
have been introduced. Do not store solutions containing additives.
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| dailymed-instance:descripti... |
Potassium Chloride in 5% Dextrose and Sodium Chloride Injection, USP is a sterile, nonpyrogenic solution for fluid and electrolyte
replenishment and caloric supply in a single dose container for intravenous administration. It contains no antimicrobial agents. Composition, osmolarity, pH, ionic concentration and
caloric content are shown in Table 1. The VIAFLEX Plus plastic container is fabricated from a specially formulated polyvinyl chloride (PL 146 Plastic). VIAFLEX Plus on
the container indicates the presence of a drug additive in a drug vehicle. The VIAFLEX Plus plastic container system utilizes the same container as the VIAFLEX plastic container system.
The amount of water that can permeate from inside the container into the overwrap is insufficient to affect the solution significantly. Solutions in contact with the plastic container
can leach out certain of its chemical components in very small amounts within the expiration period, e.g., di-2-ethylhexyl phthalate (DEHP), up to 5 parts per million. However, the
safety of the plastic has been confirmed in tests in animals according to USP biological tests for plastic containers as well as by tissue culture toxicity studies.
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| dailymed-instance:clinicalP... |
Potassium Chloride in 5% Dextrose and Sodium Chloride Injection, USP has value as a source of water, electrolytes and calories. It
is capable of inducing diuresis depending on the clinical condition of the patient.
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| dailymed-instance:contraind... |
Solutions containing dextrose may be contraindicated in patients with known allergy to corn or corn products.
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| dailymed-instance:supply |
Potassium Chloride in 5% Dextrose and Sodium Chloride Injection, USP in VIAFLEX Plus plastic container is available as follows: Exposure of pharmaceutical products to heat should be minimized. Avoid excessive heat. It is recommended the product be stored at
room temperature (25��C); brief exposure up to 40��C does not adversely affect the product.
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| dailymed-instance:precautio... |
Clinical evaluation and periodic laboratory determinations are necessary to monitor changes in fluid balance, electrolyte
concentrations, and acid base balance during prolonged parenteral therapy or whenever the condition of the patient warrants such evaluation. Caution must be exercised in the administration of Potassium Chloride in 5% Dextrose and Sodium Chloride Injection, USP to patients
receiving corticosteroids or corticotropin. Potassium Chloride in 5% Dextrose and Sodium Chloride Injection, USP should be used with caution in patients with overt or
subclinical diabetes mellitus.<br/>Pregnancy::<br/>Teratogenic Effects:<br/>Pediatric Use: Safety and effectiveness of Potassium Chloride in 5% Dextrose and Sodium Chloride Injection, USP in pediatric patients have not
been established by adequate and well-controlled studies. However, the use of potassium chloride injection in pediatric patients to treat potassium deficiency states when oral
replacement therapy is not feasible is referenced in the medical literature. Dextrose is safe and effective for the stated indications in pediatric patients (see Indications and Usage). As reported in the literature, the dosage
selection and constant infusion rate of intravenous dextrose must be selected with caution in pediatric patients, particularly neonates and low birth weight infants, because of the
increased risk of hyperglycemia/hypoglycemia. Frequent monitoring of serum glucose concentrations is required when dextrose is prescribed to pediatric patients, particularly neonates
and low birth weight infants.<br/>Carcinogenesis, mutagenesis, impairment of fertility: Studies with Potassium Chloride in 5% Dextrose and Sodium Chloride Injection, USP have not been performed to evaluate
carcinogenic potential, mutagenic potential or effects on fertility.<br/>Nursing Mothers: It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be
exercised when Potassium Chloride in 5% Dextrose and Sodium Chloride Injection, USP is administered to a nursing mother. For patients receiving potassium supplement at greater than maintenance rates, frequent monitoring of serum potassium levels
and serial EKGs are recommended. Do not administer unless solution is clear and seal is intact.
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| dailymed-instance:genericMe... |
Potassium Chloride, Dextrose monohydrate, Sodium Chloride
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| dailymed-instance:fullName |
Potassium Chloride in Dextrose and Sodium Chloride (Injection, Solution)
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| dailymed-instance:adverseRe... |
Reactions which may occur because of the solution or the technique of administration include febrile response, infection at the
site of injection, venous thrombosis or phlebitis extending from the site of injection, extravasation, and hypervolemia. If an adverse reaction does occur, discontinue the infusion, evaluate the patient, institute appropriate therapeutic
countermeasures, and save the remainder of the fluid for examination if deemed necessary.
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| dailymed-instance:warning |
Potassium Chloride in 5% Dextrose and Sodium Chloride Injection, USP should be used with great care, if at all, in patients with
congestive heart failure, severe renal insufficiency, and in clinical states in which there exists edema with sodium retention. Potassium Chloride in 5% Dextrose and Sodium Chloride Injection, USP should be used with great care, if at all, in patients with
hyperkalemia, severe renal failure, and in conditions in which potassium retention is present. Injections containing carbohydrates with low electrolyte concentration should not be administered simultaneously with blood through
the same administration set because of the possibility of pseudoagglutination or hemolysis. The container label for these injections bears the statement: Do not administer simultaneously
with blood. The intravenous administration of Potassium Chloride in 5% Dextrose and Sodium Chloride Injection, USP can cause fluid and/or
solute overloading resulting in dilution of serum electrolyte concentrations, overhydration, congested states or pulmonary edema. The risk of dilutional states is inversely proportional
to the electrolyte concentrations of the injection. The risk of solute overload causing congested states with peripheral and pulmonary edema is directly proportional to the electrolyte
concentrations of the injection. In patients with diminished renal function, administration of Potassium Chloride in 5% Dextrose and Sodium Chloride Injection, USP
may result in sodium or potassium retention. In very low birth weight infants, excessive or rapid administration of dextrose injection may result in increased serum osmolality
and possible intracerebral hemorrhage. Potassium salts should never be administered by IV push.
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| dailymed-instance:indicatio... |
Potassium Chloride in 5% Dextrose and Sodium Chloride Injection, USP is indicated as a source of water, electrolytes and
calories.
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| dailymed-instance:name |
Potassium Chloride in Dextrose and Sodium Chloride
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