Source:http://www4.wiwiss.fu-berlin.de/dailymed/resource/drugs/2287
| Predicate | Object |
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| rdf:type | |
| rdfs:label |
Avita (Cream)
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| dailymed-instance:dosage |
AVITA Cream should be applied once a day, in the evening, to the skin where acne lesions appear, using enough to cover the entire affected area lightly. Application may cause a transient feeling of warmth or slight stinging. In cases where it has been necessary to temporarily discontinue therapy or reducethe frequency of application, therapy may be resumed or frequency of application increased when the patients become able to tolerate the treatment. Alterations of dose frequency should be closely monitored by careful observation of the clinical therapeutic response and skin tolerance. Efficacy has not been established for less than once-daily dosing frequencies. During the early weeks of therapy, an apparent increase in number and exacerbation of inflammatory acne lesions may occur. This is due, in part, to the action of the medication on deep, previously unseen lesions and should not be considered a reason to discontinue therapy. Therapeutic results should be
noticed after two to three weeks but more than six weeks of therapy may be required before definite beneficial
effects are seen. Patients treated with AVITA Cream may use cosmetics, but the areas to be treated should be cleansed thoroughly before the medication is applied (see Precautions Section).
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| dailymed-instance:descripti... |
AVITA Cream, a topical retinoid, contains tretinoin 0.025% by weight in a hydrophilic cream vehicle of stearic acid, polyolprepolymer-2, isopropyl myristate, polyoxyl 40 stearate, propylene glycol, stearyl alcohol, xanthan gum, sorbic acid, butylated hydroxytoluene, and purified water. Chemically, tretinoin is all-transretinoic acid (CH; molecular weight 300.44 vitamin A acid) and has the following structural formula:
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| dailymed-instance:clinicalP... |
Although the exact mode of action of tretinoin is unknown, current evidence suggests that topical tretinoin decreases cohesiveness of follicular epithelial cells with decreased microcomedo formation.
Additionally, tretinoin stimulates mitotic activity and increased turnover of follicular epithelial cells causing
extrusion of the comedones.<br/>Pharmacokinetics: In vitro and in vivo pharmacokinetic studies with AVITA Cream indicate that less than 0.3% of the topically applied dose is bioavailable. Circulating plasma levels of both tretinoin and isotretinoin are only slightly elevated above those found in healthy normal controls.<br/>CLINICAL STUDIES: In one vehicle-controlled clinical trial, AVITA(tretinoin cream) Cream 0.025%, applied once daily was more effective than vehicle in the treatment of facial acne vulgaris of mild to moderate severity. Percent reductions in lesion count after treatment for 12 weeks in this study are shown in the following table:
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| dailymed-instance:activeIng... | |
| dailymed-instance:contraind... |
The product should not be used if there is hypersensitivity to any of the ingredients.
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| dailymed-instance:supply |
AVITA (tretinoin cream) Cream, 0.025% is supplied as:<br/>Storage Conditions: Store below 30��C (86��F); avoid freezing.
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| dailymed-instance:genericDr... | |
| dailymed-instance:activeMoi... | |
| dailymed-instance:inactiveI... |
dailymed-ingredient:butylated_hydroxytoluene,
dailymed-ingredient:isopropyl_myristate,
dailymed-ingredient:polyolprepolymer-2,
dailymed-ingredient:polyoxyl_40_stearate,
dailymed-ingredient:propylene_glycol,
dailymed-ingredient:sorbic_acid,
dailymed-ingredient:stearic_acid,
dailymed-ingredient:stearyl_alcohol,
dailymed-ingredient:water,
dailymed-ingredient:xanthan_gum
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| dailymed-instance:possibleD... | |
| dailymed-instance:overdosag... |
If medication is applied excessively, no more rapid or better results will be obtained and marked redness, peeling, or discomfort may occur. Oral ingestion of the drug may lead to the same side effects as those associated with excessive oral intake of vitamin A.
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| dailymed-instance:genericMe... |
tretinoin
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| dailymed-instance:fullName |
Avita (Cream)
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| dailymed-instance:adverseRe... |
The skin of certain sensitive individuals may become excessively red, edematous, blistered, or crusted. If these effects occur, the medication should either be discontinued until the integrity of the skin is restored, or the medication dosing frequency should be adjusted temporarily to a level the patient can tolerate. However, efficacy has not been established for lower dosing frequencies. True contact allergy to topical tretinoin is rarely encountered. Temporary hyper- or hypopigmentation has been reported with repeated application of AVITA Cream. Some individuals have been reported to have heightened susceptibility to sunlight while under treatment with AVITA Cream. Adverse effects of
AVITA Cream have been reversible upon discontinuation of therapy (see Dosage and Administration Section).
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| dailymed-instance:indicatio... |
AVITA Cream is indicated for topical application in the treatment of acne vulgaris. The safety and efficacy of this product in the treatment of other disorders have not been established.
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| dailymed-instance:represent... | |
| dailymed-instance:routeOfAd... | |
| dailymed-instance:name |
Avita
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