Source:http://www4.wiwiss.fu-berlin.de/dailymed/resource/drugs/2211
| Predicate | Object |
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| rdf:type | |
| rdfs:label |
Clobetasol Propionate (Cream)
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| dailymed-instance:dosage |
Apply a thin layer of clobetasol propionate cream (emollient) to the affected skin areas twice daily and rub in gently and completely . Clobetasol propionate cream (emollient) is a super-high potency topical corticosteroid; therefore, treatment should be limited to 2 consecutive weeks and amounts greater than 50 g/week should not be used. In moderate to severe plaque-type psoriasis, clobetasol propionate cream (emollient) applied to 5% to 10% of body surface area can be used up to 4 weeks. The total dosage should not exceed 50 g/week. When dosing for more than 2 weeks, any additional benefits of extending treatment should be weighed against the risk of HPA suppression. As with other highly active corticosteroids, therapy should be discontinued when control has been achieved. If no improvement is seen within 2 weeks, reassessment of diagnosis may be necessary. Treatment beyond 4 consecutive weeks is not recommended. Use in pediatric patients under 16 years of age has not been studied. Clobetasol propionate cream (emollient) should not be used with occlusive dressings.
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| dailymed-instance:descripti... |
Clobetasol propionate cream (emollient) contains the active compound clobetasol propionate, a synthetic corticosteroid, for topical dermatologic use. Clobetasol, an analog of prednisolone, has a high degree of glucocorticoid activity and a slight degree of mineralocorticoid activity. Chemically, clobetasol propionate is (11��,16��)-21-chloro-9-fluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)-pregna-1,4-diene-3,20-dione and it has the following structural formula: Clobetasol propionate has the molecular formula CHClFOand a molecular weight of 466.98. It is a white to cream-colored crystalline powder insoluble in water. Clobetasol propionate cream (emollient) contains clobetasol propionate 0.5 mg/g in an emollient base of cetomacrogol 1000, cetostearyl alcohol, citric acid, dimethicone 350, imidurea, isopropyl myristate, propylene glycol, purified water, and sodium citrate.
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| dailymed-instance:clinicalP... |
Like other topical corticosteroids, clobetasol propionate has anti-inflammatory, antipruritic, and vasoconstrictive properties. The mechanism of the anti-inflammatory activity of the topical steroids, in general, is unclear. However, corticosteroids are thought to act by the induction of phospholipase Ainhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A.<br/>Pharmacokinetics: The extent of percutaneous absorption of topical corticosteroids is determined by many factors, including the vehicle and the integrity of the epidermal barrier. Occlusive dressing with hydrocortisone for up to 24 hours has not been demonstrated to increase penetration; however, occlusion of hydrocortisone for 96 hours markedly enhances penetration. Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin may increase percutaneous absorption. Studies performed with clobetasol propionate cream (emollient) indicate that it is in the super-high range of potency as compared with other topical corticosteroids.
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| dailymed-instance:activeIng... | |
| dailymed-instance:contraind... |
Clobetasol propionate cream (emollient) is contraindicated in those patients with a history of hypersensitivity to any of the components of the preparation.
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| dailymed-instance:supply |
Clobetasol propionate cream (emollient) USP, 0.05% is supplied in 15g, 30g, and 60g tubes. Store at 20��- 25��C (68��- 77��F) [see USP Controlled Room Temperature]. Do not refrigerate.
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| dailymed-instance:activeMoi... | |
| dailymed-instance:inactiveI... |
dailymed-ingredient:cetomacrogol_1000,
dailymed-ingredient:cetostearyl_alcohol,
dailymed-ingredient:citric_acid,
dailymed-ingredient:dimethicone_350,
dailymed-ingredient:imidurea,
dailymed-ingredient:isopropyl_myristate,
dailymed-ingredient:propylene_glycol,
dailymed-ingredient:sodium_citrate,
dailymed-ingredient:water
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| dailymed-instance:overdosag... |
Topically applied clobetasol propionate cream (emollient) can be absorbed in sufficient amounts to produce systemic effects.
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| dailymed-instance:genericMe... |
Clobetasol Propionate
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| dailymed-instance:fullName |
Clobetasol Propionate (Cream)
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| dailymed-instance:adverseRe... |
In controlled trials with all clobetasol propionate formulations, the following adverse reactions have been reported: burning/stinging, pruritus, irritation, erythema, folliculitis, cracking and fissuring of the skin, numbness of the fingers, tenderness in the elbow, skin atrophy, and telangiectasia. The incidence of local adverse reactions reported in the trials with clobetasol propionate cream (emollient) was<2% of patients treated with the exception of burning/stinging, which occurred in 5% of treated patients. Cushing's syndrome has been reported in infants and adults as a result of prolonged use of other topical clobetasol propionate formulations. The following additional local adverse reactions are reported infrequently with topical corticosteroids, but may occur more frequently with super-high potency corticosteroids such as clobetasol propionate cream (emollient). These reactions are listed in an approximately decreasing order of occurrence: dryness, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, secondary infection, striae, and miliaria.
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| dailymed-instance:indicatio... |
Clobetasol propionate cream (emollient) is a super-high potency corticosteroid formulation indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Treatment beyond 2 consecutive weeks is not recommended, and the total dosage should not exceed 50 g/week because of the potential for the drug to suppress the hypothalamic-pituitary-adrenal (HPA) axis. Use in pediatric patients under 12 years of age is not recommended. In the treatment of moderate to severe plaque-type psoriasis, clobetasol propionate cream (emollient) applied to 5% to 10% of body surface area can be used up to 4 consecutive weeks. The total dosage should not exceed 50 g/week. When dosing for more than 2 weeks, any additional benefits of extending treatment should be weighed against the risk of HPA suppression. Treatment beyond 4 consecutive weeks is not recommended. Patients should be instructed to use clobetasol propionate cream (emollient) for the minimum amount of time necessary to achieve the desired results . Use in pediatric patients under 16 years of age has not been studied.
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| dailymed-instance:represent... | |
| dailymed-instance:routeOfAd... | |
| dailymed-instance:name |
Clobetasol Propionate
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