Source:http://www4.wiwiss.fu-berlin.de/dailymed/resource/drugs/1955
| Predicate | Object |
|---|---|
| rdf:type | |
| rdfs:label |
Amoxicillin (Capsule)
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| dailymed-instance:clinicalP... |
Microbiology: Staphylococcus
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| dailymed-instance:activeIng... | |
| dailymed-instance:genericDr... | |
| dailymed-instance:activeMoi... | |
| dailymed-instance:inactiveI... |
dailymed-ingredient:D&C_Red_No._28,
dailymed-ingredient:FD&C_Blue_No._1,
dailymed-ingredient:FD&C_Red_No._40,
dailymed-ingredient:Gelatin,
dailymed-ingredient:Magnesium_Stearate,
dailymed-ingredient:Microcrystalline_Cellulose,
dailymed-ingredient:Sodium_Lauryl_Sulfate,
dailymed-ingredient:Titanium_Dioxide
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| dailymed-instance:precautio... |
General:<br/>Laboratory Tests:<br/>Drug Interactions:<br/>Drug/Laboratory Test Interactions:<br/>Carcinogenesis, Mutagenesis, Impairment of Fertility: Long-term studies in animals have not been performed to evaluate carcinogenic potential. Studies to detect mutagenic potential of amoxicillin alone have not been conducted; however, the following information is available from tests on a 4:1 mixture of amoxicillin and potassium clavulanate (AUGMENTIN). AUGMENTIN was non-mutagenic in the Ames bacterial mutation assay, and the yeast gene conversion assay. AUGMENTIN was weakly positive in the mouse lymphoma assay, but the trend toward increased mutation frequencies in this assay occurred at doses that were also associated with decreased cell survival. AUGMENTIN was negative in the mouse micronucleus test, and in the dominant lethal assay in mice. Potassium clavulanate alone was tested in the Ames bacterial mutation assay and in the mouse micronucleus test, and was negative in each of these assays. In a multi-generation reproduction study in rats, no impairment of fertility or other adverse reproductive effects were seen at doses up to 500 mg/kg (approximately 3 times the human dose in mg/m).<br/>Pregnancy:<br/>Teratogenic Effects:<br/>Labor and Delivery: Oral ampicillin-class antibiotics are poorly absorbed during labor. Studies in guinea pigs showed that intravenous administration of ampicillin slightly decreased the uterine tone and frequency of contractions but moderately increased the height and duration of contractions. However, it is not known whether use of amoxicillin in humans during labor or delivery has immediate or delayed adverse effects on the fetus, prolongs the duration of labor, or increases the likelihood that forceps delivery or other obstetrical intervention or resuscitation of the newborn will be necessary.<br/>Nursing Mothers: Penicillins have been shown to be excreted in human milk. Amoxicillin use by nursing mothers may lead to sensitization of infants. Caution should be exercised when amoxicillin is administered to a nursing woman.<br/>Pediatric Use: Because of incompletely developed renal function in neonates and young infants, the elimination of amoxicillin may be delayed. Dosing of amoxicillin should be modified in pediatric patients 12 weeks or younger (���3 months).<br/>Geriatric Use:<br/>Information for Patients:
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| dailymed-instance:genericMe... |
Amoxicillin
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| dailymed-instance:fullName |
Amoxicillin (Capsule)
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| dailymed-instance:represent... | |
| dailymed-instance:routeOfAd... | |
| dailymed-instance:name |
Amoxicillin
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