Source:http://www4.wiwiss.fu-berlin.de/dailymed/resource/drugs/1928
| Predicate | Object |
|---|---|
| rdf:type | |
| rdfs:label |
Sodium Chloride (Irrigant)
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| dailymed-instance:dosage |
The volume of slushed solution required will vary with patient's age, clinical condition, cooling effect desired and duration of
cooling effect desired, according to physician's instructions.
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| dailymed-instance:descripti... |
0.9% Sodium Chloride Irrigation, USP in the Baxter Sterile Container System is a sterile, nonpyrogenic, isotonic solution for the
preparation of slushed solution. It contains no antimicrobial agents. Composition, osmolarity, pH and ionic concentration are shown in Table 1. The Baxter Sterile Container System is designed to provide a slush container with a sterile exterior
surface for use within the surgical field. Within the overwrap, the unit is packaged in a dispensing bag which maintains the sterility of this surface. The flexible plastic slush container is fabricated from a specially formulated polyvinyl chloride (PL 146 Plastic). The amount of
water that can permeate from inside the container into the overwrap is insufficient to affect the solution significantly. Solutions in contact with the plastic container can leach out
certain of its chemical components in very small amounts within the expiration period, e.g., di-2-ethylhexyl phthalate (DEHP), up to 5 parts per million. However, the safety of the
plastic has been confirmed in tests in animals according to USP biological tests for plastic containers as well as by culture toxicity studies.
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| dailymed-instance:clinicalP... |
Slushed solution is used to induce regional hypothermia in conditions such as certain open heart and kidney surgical procedures by
direct application of slushed solution. The objective of regional hypothermia is to reduce cellular metabolic activity so that body tissues can tolerate a period of total or relative
ischemia thereby inhibiting the formation and buildup of destructive autolytic enzymes and anaerobic by-products usually produced and accumulated in ischemic tissues.
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| dailymed-instance:activeIng... | |
| dailymed-instance:contraind... |
None known
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| dailymed-instance:supply |
0.9% Sodium Chloride Irrigation, USP in the Baxter Sterile Container System is supplied as follows: Exposure of pharmaceutical products to heat should be minimized. Avoid excessive heat. Avoid freezing except during controlled
slushing procedure. It is recommended that this product be stored at room temperature (25��C); brief exposure up to 40��C does not adversely affect this product.
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| dailymed-instance:activeMoi... | |
| dailymed-instance:inactiveI... | |
| dailymed-instance:precautio... |
Avoid prolonged direct contact between ice crystals and body tissues. Experience in use of slushed solutions in pediatrics is limited.<br/>Carcinogenesis and Mutagenesis and Impairment of Fertility: Studies performed with slushed 0.9% Sodium Chloride Irrigation, USP have not been performed to evaluate carcinogenic potential,
mutagenic potential, or effects on fertility.<br/>Pregnancy:<br/>Teratogenic Effects:<br/>Nursing Mothers: It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be
exercised when slushed 0.9% Sodium Chloride Irrigation, USP is administered to a nursing mother.<br/>Pediatric Use: Safety and effectiveness of slushed 0.9% Sodium Chloride Irrigation, USP in pediatric patients have not been established by
adequate and well controlled trials; however, the use of electrolyte solutions in the pediatric population is referenced in the medical literature. The warnings, precautions and
adverse reactions identified in the labelcopy should be observed in the pediatric population. Do not administer unless seals of outer dispensing bag are intact.
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| dailymed-instance:genericMe... |
Sodium Chloride
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| dailymed-instance:fullName |
Sodium Chloride (Irrigant)
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| dailymed-instance:adverseRe... |
No serious adverse reactions are known.
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| dailymed-instance:warning |
Not for injection. For use in slush preparation for regional hypothermia.
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| dailymed-instance:indicatio... |
Slushed solution is used to create regional hypothermia in order to reduce and minimize manifestations of warm-temperature
ischemia. Temperature probes may be used to determine requirements for replacement or addition of slushed solution.
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| dailymed-instance:represent... | |
| dailymed-instance:routeOfAd... | |
| dailymed-instance:name |
Sodium Chloride
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