Source:http://www4.wiwiss.fu-berlin.de/dailymed/resource/drugs/1896
| Predicate | Object |
|---|---|
| rdf:type | |
| rdfs:label |
Cysteine Hydrochloride (Injection, Solution)
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| dailymed-instance:dosage |
Cysteine Hydrochloride Injection, USP 0.5 gram is intended
for use only after dilution in Aminosyn
(a crystalline amino acid solution). Each 10 mL of Cysteine Hydrochloride
Injection, USP 0.5 gram should be combined aseptically with 12.5 grams of
amino acids, such as that present in 250 mL of Aminosyn 5%. The admixture
is then diluted with 250 mL of dextrose 50% or such lesser volume as indicated.
Equal volumes of Aminosyn 5% and dextrose 50% produce a finalsolution which
contains Aminosyn 2.5% in dextrose 25%, which is suitable for administration
by central venous infusion. Administration of the final admixture should begin
within one hour of mixing due to the oxidative degradation of cysteine in
the higher pH environment of the amino acid and dextrose admixture. Otherwise,
the admixture should be refrigerated immediately and used within 12 hours
of the time of mixing. For the recommended rate of administration, see the
Aminosyn package insert. Parenteral drug products should
be inspected visually for particulate matter and discoloration prior to administration
whenever solution and container permit.
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| dailymed-instance:descripti... |
Cysteine Hydrochloride Injection, USP 0.5 gram is a sterile,
nonpyrogenic solution containing 0.5 gram of cysteine hydrochloride, monohydrate
in 10 mL of water for injection. The pH is 1.3 (1.0 to 2.5). Specific gravity
is 1.02; contains 0.285 mMol cysteine/mL. Cysteine is a sulfur-containing
amino acid. In premixed solutions of crystalline amino acids, cysteine is
relatively unstable over time, eventually converting to insoluble cystine.
To avoid such precipitation, Cysteine Hydrochloride Injection, USP is provided
as an additive for use with crystalline amino acid solutions immediately prior
to administration to the patient. Cysteine Hydrochloride,
USP, monohydrate is chemically designated CHNOS���HCI���HO, a white crystalline powder soluble in
water. It has the following structural formula:
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| dailymed-instance:clinicalP... |
Cysteine is synthesized from methionine via the trans-sulfuration
pathway in the adult, but newborn infants lack the enzyme, cystathionase,
necessary to effect this conversion. Therefore, Cysteine Hydrochloride Injection,
USP is generally considered to be an essential amino acid in infants. Metabolism
of cysteine produces pyruvate and inorganic sulfate as end products. Cysteine
is introduced directly into the pathway of carbohydrate metabolism at the
pyruvate stage with all three carbons convertible to glucose. The sulfur is
primarily transformed to inorganic sulfate, which is introduced into complex
polysaccharides among other structural components.
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| dailymed-instance:activeIng... | |
| dailymed-instance:supply |
Cysteine Hydrochloride Injection, USP 0.5 gram (50 mg/mL)
is supplied as follows: Exposure of pharmaceutical products to heat should be minimized.
Avoid excessive heat. Protect from freezing. Store at
20 to 25��C (68 to 77��F). [See USP Controlled Room Temperature.] Abboject is
a trademark of the Abbott group of companies. Rev:
October, 2004 HOSPIRA, INC., LAKE FOREST,
IL 60045 USA
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| dailymed-instance:boxedWarn... |
CAUTION: MUST BE DILUTED
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| dailymed-instance:activeMoi... | |
| dailymed-instance:inactiveI... | |
| dailymed-instance:overdosag... |
In the event of overhydration or solute overload, re-evaluate
the patient and institute appropriate corrective measures. SEE WARNINGS and
PRECAUTIONS appearing in accompanying Aminosyn package insert.
|
| dailymed-instance:genericMe... |
Cysteine Hydrochloride
|
| dailymed-instance:fullName |
Cysteine Hydrochloride (Injection, Solution)
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| dailymed-instance:indicatio... |
Cysteine Hydrochloride Injection, USP 0.5 gram is indicated
for use only after dilution as an additive
to Aminosyn (a crystalline amino acid solution) to meet the intravenous amino
acid nutritional requirements of infants receiving total parenteral nutrition.
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| dailymed-instance:represent... | |
| dailymed-instance:routeOfAd... | |
| dailymed-instance:name |
Cysteine Hydrochloride
|