Source:http://www4.wiwiss.fu-berlin.de/dailymed/resource/drugs/1840
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| rdfs:label |
Lindane (Lotion)
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| dailymed-instance:dosage |
Apply a thin layer of Lindane Lotion over all skin from the neck down. One ounce is sufficient for an average adult. Do not prescribe more than 2 ounces for larger adults. Apply only once. Wash off in 8 to 12 hours. Do not retreat. Patients should be provided specific information on use of product. Patients should be instructed on proper use of Lindane Lotion, especially the amount to apply, how long to leave on and the need to avoid retreatment. Patients should be informed that itching occurs after the successful killing of scabies (lice) and continued itching is not necessarily an indication for retreatment with Lindane Lotion. A Lindane Lotion Medication Guide must be given to the patient each time Lindane Lotion is dispensed, as required by law. The Lindane Lotion Medication Guide is an important part of the risk management program for the patient.
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| dailymed-instance:descripti... |
Lindane Lotion, USP 1%, is an ectoparasiticide and ovicide. In addition to the active ingredient, lindane, it contains 2-amino-2-methyl-1-propanol, carrageenan, cetyl alcohol, cocoa butter, glyceryl monostearate, methylparaben, propylene glycol, propylparaben, purified water, stearic acid and trolamine toform a lotion. The pH range is between 6.5 and 8.5. Lindane is the gamma isomer of 1,2,3,4,5,6-hexachlorocyclohexane having the following structural formula:
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| dailymed-instance:clinicalP... |
Lindane Lotion, USP 1%, is an ectoparasiticide and ovicide effective against Sarcoptes scabiei (scabies). Lindane exerts its parasiticidal action by being directly absorbed into the parasites and their ova. Feldmann and Maibachreported approximately 10% systemic absorption of a lindane acetone solution when applied to the forearm of human subjects and left in place for 24 hours. This vehicle was different from the approved product and the percutaneous penetration of lindane is dependent on the vehicle. Therefore, the clinical significance of these observations is unknown. Dale, et alreported a blood level of 290 ng/mL associated with convulsions following the accidental ingestion of a lindane-containing product. Ginsburgfound the greatest peak blood level of 64 ng/mL, 6 hours after total body application of Lindane Lotion in 1 of 8 non-scabietic pediatric patients. The half-life in blood was determined to be approximately 18 hours. Data available in the literature suggest that lindane has a rapid distribution phase followed by a longer��-elimination phase.
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| dailymed-instance:activeIng... | |
| dailymed-instance:contraind... |
Lindane Lotion is contraindicated in premature infants and individuals with known uncontrolled seizure disorders.
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| dailymed-instance:supply |
Lindane Lotion, USP 1% is supplied in patient-size 2 fl oz (60 mL) bottles. SHAKE WELL BEFORE USING Store at controlled room temperature, 15�����30��C (59�����86��F) [see USP].
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| dailymed-instance:genericDr... | |
| dailymed-instance:boxedWarn... |
WARNINGS: Lindane Lotion should only be used in patients who cannot tolerate or have failed first-line treatment with safer medications for the treatment of scabies.<br/>Neurologic Toxicity: Seizures and deaths have been reported following Lindane Lotion use with repeat or prolonged application, but also in rare cases following a single application used according to directions. Lindane Lotion should be used with caution for infants, children, the elderly, and individuals with other skin conditions (e.g., atopic dermatitis, psoriasis) and in those who weigh<110 lbs (50 kg) as they may be at risk of serious neurotoxicity.<br/>Contraindications: Lindane Lotion is contraindicated in premature infants and individuals with known uncontrolled seizure disorders.<br/>Proper Use: Instruct patients on the proper use of Lindane Lotion, the amount to apply, how long to leave it on, and avoiding retreatment. Inform patients that itching occurs after the successful killing of scabies and is not necessarily an indication for retreatment with Lindane Lotion.
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| dailymed-instance:activeMoi... | |
| dailymed-instance:inactiveI... |
dailymed-ingredient:2-amino-2-methyl-1-propanol,
dailymed-ingredient:carrageenan,
dailymed-ingredient:cetyl_alcohol,
dailymed-ingredient:cocoa_butter,
dailymed-ingredient:glyceryl_monostearate,
dailymed-ingredient:methylparaben,
dailymed-ingredient:propylene_glycol,
dailymed-ingredient:propylparaben,
dailymed-ingredient:stearic_acid,
dailymed-ingredient:trolamine,
dailymed-ingredient:water
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| dailymed-instance:overdosag... |
Contact the closest Poison Control Center in the event of suspected overdosage with Lindane Lotion. If accidental ingestion occurs, prompt gastric lavage should be instituted. However, since oils enhance absorption, saline cathartics for intestinal evacuation should be given rather than oil laxatives. If central nervous system (CNS) manifestations occur, they may be antagonized by the administration of pentobarbital, phenobarbital, or diazepam.
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| dailymed-instance:genericMe... |
Lindane
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| dailymed-instance:fullName |
Lindane (Lotion)
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| dailymed-instance:adverseRe... |
Lindane Lotion has been reported to cause central nervous system stimulation ranging from dizziness to seizures. Although seizures were almost always associated with ingestion or misuse of the product (to include repeat treatment), seizures and deaths have been reported when Lindane Lotion was used according to directions. Irritant dermatitis from contact with this product has also been reported.<br/>Postmarketing Experience: The following adverse reactions reflect additional postmarketing experience of Lindane Lotion. These events include alopecia, dermatitis, headache, pain, paresthesia, pruritus and urticaria. The relationship of some of these events to Lindane therapy is unknown.
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| dailymed-instance:warning |
Lindane Lotion should only be used in patients who cannot tolerate or have failed first-line treatment with safer medications for the treatment of scabies.<br/>Neurologic Toxicity: Seizures and deaths have been reported following Lindane Lotion use with repeat or prolonged application, but also in rare cases following a single application used according to directions. Lindane Lotion should be used with caution for infants, children, the elderly, and individuals with other skin conditions (e.g., atopic dermatitis, psoriasis) and in those who weigh<110 lbs (50 kg) as they may be at risk of serious neurotoxicity.<br/>Contraindications: Lindane Lotion is contraindicated in premature infants and individuals with known uncontrolled seizure disorders.<br/>Proper Use: Instruct patients on the proper use of Lindane Lotion, the amount to apply, how long to leave it on, and avoiding retreatment. Inform patients that itching occurs after the successful killing of scabies and is not necessarily an indication for retreatment with Lindane Lotion.
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| dailymed-instance:indicatio... |
Lindane Lotion is indicated for the treatment of scabies (infestations of Sarcoptes scabei ) only in patients who: Lindane Lotion should be used in the context of an overall scabies management program that includes: Caregivers applying this product to patients should wear gloves less permeable to Lindane, such as nitrile, latex with neoprene, or sheer vinyl, and thoroughly clean hands after application. Natural latex gloves should be avoided because they are more permeable to Lindane. Lindane Lotion does not prevent infestation or reinfestation and should not be used to ward off a possible infestation.
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| dailymed-instance:represent... | |
| dailymed-instance:routeOfAd... | |
| dailymed-instance:name |
Lindane
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