Source:http://www4.wiwiss.fu-berlin.de/dailymed/resource/drugs/1579
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| rdf:type | |
| rdfs:label |
Dermatop (Ointment)
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| dailymed-instance:dosage |
Apply a thin film of DERMATOP Ointment 0.1% to the affected skin areas twice daily. Rub in gently.
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| dailymed-instance:descripti... |
DERMATOP Ointment (prednicarbate ointment) 0.1% contains the non-halogenated prednisolone derivative prednicarbate. The topical corticosteroids constitute a class of primarily synthetic steroids used topically as anti-inflammatory and anti-pruritic agents.
Each gram of DERMATOP Ointment 0.1% contains 1.0mg of prednicarbate in a base consisting of white petrolatum, octyldodecanol, glyceryl oleate, propylene glycol, citric acid, and propyl gallate. Prednicarbate has the empirical formula CHOand a molecular weight of 488.58. The CAS Registry Number is 73771-04-7. The chemical structure is:
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| dailymed-instance:clinicalP... |
Pharmacokinetics: The extent of percutaneous absorption of topical corticosteroids is determined by many factors, including the vehicle and the integrity of the epidermal barrier. Occlusive dressings with hydrocortisone for up to 24 hours have not been demonstrated to increase penetration; however, occlusion of hydrocortisone for 96 hours markedly enhances penetration. Topical corticosteroids can be absorbed from normal intact skin while inflammation and/or other disease processes in the skinincrease percutaneous absorption. Studies performed with DERMATOP Ointment (prednicarbate ointment)
0.1% indicate that it is in the medium range of potency as compared with other topical corticosteroids.
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| dailymed-instance:activeIng... | |
| dailymed-instance:contraind... |
DERMATOP Ointment 0.1% is contraindicated in those patients with a history of hypersensitivity to any of the components in the preparations.
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| dailymed-instance:supply |
DERMATOP Ointment (prednicarbate ointment) 0.1% is supplied in 15 gram (NDC 0066-0508-15) and 60 gram (NDC 0066-0508-60) tubes. Store at controlled room temperature (59 to 86��F or 15 to 30��C).
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| dailymed-instance:genericDr... | |
| dailymed-instance:activeMoi... | |
| dailymed-instance:inactiveI... | |
| dailymed-instance:overdosag... |
Topically applied corticosteroids can be absorbed in sufficient amounts to produce systemic effects.
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| dailymed-instance:genericMe... |
prednicarbate
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| dailymed-instance:fullName |
Dermatop (Ointment)
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| dailymed-instance:adverseRe... |
In controlled clinical studies, the incidence of adverse reactions associated with the use of DERMATOP Ointment 0.1% was approximately 1.5%. Reported reactions including burning, pruritis, drying, scaling, cracking and pain and irritant dermatitis. The following additional local adverse reactions are reported infrequently with topical corticosteroids, but may occur more frequently with the use of occlusive dressings and especially with higher potency corticosteroids. These reactions are listed in an approximate decreasing order of occurrence: folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, secondary infection, skin atrophy, striae and miliaria.
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| dailymed-instance:indicatio... |
DERMATOP Ointment 0.1% is a medium potency corticosteroid indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid responsive dermatoses.
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| dailymed-instance:represent... | |
| dailymed-instance:routeOfAd... | |
| dailymed-instance:name |
Dermatop
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