Source:http://www4.wiwiss.fu-berlin.de/dailymed/resource/drugs/1480
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| rdf:type | |
| rdfs:label |
Topicort (Ointment)
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| dailymed-instance:dosage |
Apply a thin film of Topicort (desoximetasone) Ointment 0.25% to the affected skin areas twice daily. Rub in gently.
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| dailymed-instance:descripti... |
Topicort (desoximetasone) Ointment 0.25% contains the active synthetic corticosteroid desoximetasone. The topical corticosteroids constitute a class of primarily synthetic steroids used as anti-inflammatory and antipruritic agents. Each gram of Topicort Ointment 0.25% contains 2.5 mg of desoximetasone in an ointment base consisting of white petrolatum and fractionated coconut oil. The chemical name of desoximetasone is Pregna-1, 4-diene-3, 20-dione, 9-fluoro-11, 21-dihydroxy-16-methyl-,(11��,16��)-. Desoximetasone has the molecular formula CHFOand a molecular weight of 376.47. The CAS Registry Number is 382-67-2. The structural formula is:
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| dailymed-instance:clinicalP... |
Topical corticosteroids share anti-inflammatory, antipruritic and vasoconstrictive actions. The mechanism of anti-inflammatory activity of the topical corticosteroids is unclear. Various laboratory methods, including vasoconstrictor assays, are used to compare and predict potencies and/or clinical efficacies of the topical corticosteroids. There is some evidence to suggest that a recognizable correlation exists between vasoconstrictor potency and therapeutic efficacy in man.<br/>Pharmacokinetics: The extent of percutaneous absorption of topical corticosteroids is determined by many factors including the vehicle, the integrity of the epidermal barrier, and the use of occlusive dressings. Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin increase percutaneous absorption. Occlusive dressings substantially increase the percutaneous absorption of topical corticosteroids. Thus, occlusive dressings may be a valuable therapeutic adjunct for treatment of resistant dermatoses. Once absorbed through the skin, topical corticosteroids are handled through pharmacokinetic pathways similar to systemically administered corticosteroids. Corticosteroids are bound to plasma proteins in varying degrees. Corticosteroids are metabolized primarily in the liver and are then excreted by the kidneys. Some of the topical corticosteroids and their metabolites are also excreted into the bile. Pharmacokinetic studies in men with Topicort (desoximetasone) Ointment 0.25% with tagged desoximetasone showed no detectable level (limit of sensitivity: 0.003��g/mL) in 1 subject and 0.004 and 0.006��g/mL in the remaining 2 subjects in the blood when it was applied topically on the back followed by occlusion for 24 hours. The extent of absorption for the ointment was 7% based on radioactivity recovered from urine and feces. Seven days after application, no further radioactivity was detected in urine or feces. Studies with other similarly structured steroids have shown that predominant metabolite reaction occurs through conjugation to form the glucuronide and sulfate ester.
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| dailymed-instance:activeIng... | |
| dailymed-instance:contraind... |
Topical corticosteroids are contraindicated in those patients with a history of hypersensitivity to any of the components of the preparation.
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| dailymed-instance:supply |
Topicort (desoximetasone) Ointment 0.25% is supplied in 5 gram tubes for physician samples, 15 gram and 60 gram tubes. Store at controlled room temperature 15��-30��C (59��-86��F).
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| dailymed-instance:genericDr... | |
| dailymed-instance:activeMoi... | |
| dailymed-instance:inactiveI... | |
| dailymed-instance:overdosag... |
Topically applied corticosteroids can be absorbed in sufficient amounts to produce systemic effects .
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| dailymed-instance:genericMe... |
Desoximetasone
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| dailymed-instance:fullName |
Topicort (Ointment)
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| dailymed-instance:adverseRe... |
The following local adverse reactions are reported infrequently with topical corticosteroids, but may occur more frequently with the use of occlusive dressings. These reactions are listed in an approximate decreasing order of occurrence: In controlled clinical studies the incidence of adverse reactions was low (0.3%) for Topicort (desoximetasone) Ointment 0.25% and consisted of development of comedones at the site of application.
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| dailymed-instance:warning |
Topicort (desoximetasone) Ointment 0.25% is not for ophthalmic use. Keep out of reach of children.
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| dailymed-instance:indicatio... |
Topicort (desoximetasone) Ointment 0.25% is indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.
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| dailymed-instance:name |
Topicort
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