Source:http://www4.wiwiss.fu-berlin.de/dailymed/resource/drugs/1388
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Isopto Cetamide (Solution/ Drops)
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For conjunctivitis and other superficial ocular infections:: Solution: Instill one or two drops into the conjunctival sac(s) of the affected eye(s) every two to three hours initially. Dosages may be tapered by increasing the time interval between doses as the condition responds. The usual duration of treatment is seven to ten days. Ointment: Apply a small amount (approximately one-half inch ribbon) into the conjunctival sac(s) of the affected eye(s) every three to four hours and at bedtime. Dosages may be tapered by increasing the time interval between doses as the condition responds. The ointment may be used as adjunct to the solution. The usual duration of treatment is seven to ten days. How to apply CETAMIDE���Ointment:<br/>For Trachoma:: Solution: Instill two drops into the conjunctival sac(s) of the affected eye(s) every two hours. Topical administration must be accompanied by systemic administration.
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| dailymed-instance:clinicalP... |
Microbiology: The sulfonamides are bacteriostatic agents and the spectrum of activity is similar for all. Sulfonamides inhibit bacterial synthesis of dihydrofolic acid by preventing the condensation of the pteridine with aminobenzoic acid through competitive inhibition of the enzyme dihydropteroate synthetase. Resistant strains have altered dihydropteroate synthetase with reduced affinity for sulfonamides or produce increased quantities of aminobenzoic acid. Topically applied sulfonamides are considered active against susceptible strains of the following common bacterial eye pathogens: Escherichia coli, Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus (viridans group), Haemophilus influenzae, Klebsiella species, and Enterobacter species. Topically applied sulfonamides do not provide adequate coverage against Neisseria species, Serratia marcescens and Pseudomonas aeruginosa. A significant percentage of Staphylococcal isolates are completely resistant to sulfa drugs.
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Solution in 5mL and 15mL plastic DROP-TAINER' Dispensers. Ointment in 3.5g ophthalmic tubes: 5 mL solution - NDC 0998-0522-05 15 mL solution - NDC 0998-0522-15 3.5 g ointment - NDC 0065-0526-35<br/>STORAGE: Solution���Store at 8��- 24��C (46��- 75��F). Protect from light. Do not use if solution is discolored (dark brown). Sulfonamide solutions, on long standing, will darken in color and should be discarded. Ointment���Store at 8��- 27��C (46��-80��F). CAUTION: Federal (USA) law prohibits dispensing without prescription. 341035 Rev: January 1995 Alcon' OPHTHALMIC ALCON LABORATORIES, INC. Fort Worth, TX 76134 USA Printed in USA
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sulfacetamide sodium
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Isopto Cetamide (Solution/ Drops)
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| dailymed-instance:adverseRe... |
Bacterial and fungal corneal ulcers have developed during treatment with sulfonamide ophthalmic preparations. The most frequently reported reactions are local irritation, stinging and burning. Less commonly reported reactions include non-specific conjunctivitis, conjunctival hyperemia, secondary infections and allergic reactions. Fatalities have occurred, although rarely, due to severe reactions to sulfonamides including Stevens-Johnsonsyndrome, toxic epidermal necrolysis, fulminant hepatic necrosis, agranulocytosis, aplastic anemia, and other blood dyscrasias .
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Solution: For the treatment of conjunctivitis and other superficial ocular infections due to susceptible microorganisms and as an adjunctive in systemic sulfonamide therapy of trachoma: Escherichia coli, Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus (viridans group), Haemophilus influenzae, Klebsiella species, and Enterobacter species.<br/>Ointment: For the treatment of conjunctivitis and other superficial ocular infections due to susceptible microorganisms. Topically applied sulfonamides do not provide adequate coverage against Neisseria species, Serratia marcescens and Pseudomonas aeruginosa. A significant percentage of staphylococcal isolates are completely resistant to sulfa drugs.
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Isopto Cetamide
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