Source:http://www4.wiwiss.fu-berlin.de/dailymed/resource/drugs/1384
| Predicate | Object |
|---|---|
| rdf:type | |
| rdfs:label |
Anusol HC (Cream)
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| dailymed-instance:dosage |
Anusol-HC2.5% (Hydrocortisone Cream, USP) should be applied to the affected area two to four times daily depending on the severity of the condition. Occlusive dressings may be used for the management of psoriasis or recalcitrant conditions. If an infection develops, the use of occlusive dressings should be discontinued and appropriate antimicrobial therapy instituted.
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| dailymed-instance:descripti... |
The topical corticosteroids constitute a class of primarily synthetic steroids used as antiinflammatory and antipruritic agents. Anusol-HC 2.5% (Hydrocortisone Cream, USP) is a topical corticosteroid with hydrocortisone 2.5% (active ingredient) in a water-washable cream containing the following inactive ingredients: benzyl alcohol, petrolatum, stearyl alcohol, propylene glycol, isopropyl myristate, polyoxyl 40 stearate, carbomer 934, sodium lauryl sulfate, edetate disodium, sodium hydroxide to adjust the pH, and purified water. Hydrocortisone has the chemical name Pregn-4-ene-3,20-dione, 11,17, 21, trihydroxy-,(11��) - and the following chemical structure:
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| dailymed-instance:clinicalP... |
Topical corticosteroids share antiinflammatory, antipruritic and vasoconstrictive actions. The mechanism of antiinflammatory activity of the topical corticosteroids is unclear. Various laboratory methods, including vaso-constrictor assays, are used to compare and predict potencies and/or clinical efficacies of the topical corticosteroids. There is some evidence to suggest that a recognizable correlation exists between vasoconstrictor potency and therapeutic efficacy in man.<br/>Pharmacokinetics: The extent of percutaneous absorption of topical corticosteroids is determined by many factors including the vehicle, the integrity of the epidermal barrier, and the use of occlusive dressings. Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin increase percutaneous absorption. Occlusive dressings substantially increase the percutaneous absorption of topical corticosteroids. Thus, occlusive dressings may be a valuable therapeutic adjunct for treatment of resistant dermatoses . Once absorbed through the skin, topical corticosteroids are handled through pharmacokinetic pathways similar to systemically administered corticosteroids. Corticosteroids are bound to plasma proteins in varying degrees. Corticosteroids are metabolized primarily in the liver and are then excreted by the kidneys. Some of the topical corticosteroids and their metabolites are also excreted into the bile.
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| dailymed-instance:activeIng... | |
| dailymed-instance:contraind... |
Topical corticosteroids are contraindicated in those patients with a history of hypersensitivity to any of the components of the preparation.
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| dailymed-instance:supply |
Anusol-HC2.5% (Hydrocortisone Cream, USP) is supplied in 30 gram tubes (NDC 65649-401-30). Store at 20�����25��C (68�����77��F). See USP Controlled Room Temperature. Protect from freezing. Store away from heat. Prescribing Information as of March 2005.Manufactured for: Salix Pharmaceuticals, Inc., Morrisville, NC 27560 6420Rev. 3/05 3000236-B
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| dailymed-instance:genericDr... | |
| dailymed-instance:activeMoi... | |
| dailymed-instance:inactiveI... |
dailymed-ingredient:benzyl_alcohol,
dailymed-ingredient:carbomer_934,
dailymed-ingredient:edetate_disodium,
dailymed-ingredient:isopropyl_myristate,
dailymed-ingredient:petrolatum,
dailymed-ingredient:polyoxyl_40_stearate,
dailymed-ingredient:propylene_glycol,
dailymed-ingredient:sodium_hydroxide,
dailymed-ingredient:sodium_lauryl_sulfate,
dailymed-ingredient:stearyl_alcohol,
dailymed-ingredient:water
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| dailymed-instance:possibleD... | |
| dailymed-instance:overdosag... |
Topically applied corticosteroids can be absorbed in sufficient amounts to produce systemic effects.
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| dailymed-instance:genericMe... |
hydrocortisone
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| dailymed-instance:fullName |
Anusol HC (Cream)
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| dailymed-instance:adverseRe... |
The following local adverse reactions are reported infrequently with topical corticosteroids, but may occur more frequently with the use of occlusive dressings. These reactions are listed in an approximate decreasing order of occurrence:
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| dailymed-instance:indicatio... |
Topical corticosteroids are indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.
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| dailymed-instance:represent... | |
| dailymed-instance:routeOfAd... | |
| dailymed-instance:name |
Anusol HC
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