Source:http://www4.wiwiss.fu-berlin.de/dailymed/resource/drugs/1322
| Predicate | Object |
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| rdf:type | |
| rdfs:label |
Triamcinolone Acetonide (Cream)
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| dailymed-instance:dosage |
Topical corticosteroids are generally applied to the affected area as a thin film from two to four times daily depending on the severity of the condition. Occlusive dressing may be used for the management of psoriasis or recalcitrant conditions. If an infection develops, the use of occlusive dressing should be discontinued and appropriate antimicrobial therapy instituted.
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| dailymed-instance:descripti... |
The topical corticosteriods constitute a class of primarily synthetic steroids used as anti-inflammatory and antipruritic agents. Triamcinolone acetonide is designated chemically as pregna-1,4-diene-3, 20-dione, 9-fluoro-11, 21-dihydroxy-16, 17-[(1-methylethylidene)bis (0xy)]-, (11��, 16��)-. CHFO,M.W.:434.51; CAS Reg.No.:76-25-5. Each gram of 0.025%, 0.1% and 0.5% Triamcinolone Acetonide Cream USP provides 0.25 mg, 1 mg, or 5 mg triamcinolone acetonide respectively in a washable cream base of : Purified Water, Cetyl Alcohol, Propylene Glycol, Glyceryl Monostearate, Glycerin, Cetyl Esters Wax, Polysorbate-60, Sorbitan Monostearate, Isopropyl Palmitate and Sorbic Acid. Each gram of 0.025%, 0.1% and 0.5% Triamcinolone Acetonide Ointment USP provides 0.25 mg, 1 mg, or 5 mg triamcinolone acetonide respectively in an ointment base of White Petrolatum and Light Mineral Oil.
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| dailymed-instance:clinicalP... |
Topical corticosteroids share anti-inflammatory, anti-pruritic and vasoconstrictive actions. The mechanism of anti-inflammatory activity of the topical corticosteroids is unclear. Various laboratory methods, including vasoconstrictor assays, are used to compare and predict potencies and/or clinical efficacies of the topical corticosteroids. There is some evidence to suggest that a recognizable correlation exists between vasoconstrictor potency and therapeutic efficacy in man.<br/>Pharmacokinetics: The extent of percutaneous absorption of topical corticosteroids is determined by many factors including the vehicle, the integrity of the epidermal barrier, and the use of occlusive dressings. Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin increase percutaneous absorption. Occlusive dressings substantially increase the percutaneous absorption of topical corticosteroids. Thus, occlusive dressings may be a valuable therapeutic adjunct for treatment of resistant dermatoses. . Once absorbed through the skin, topical corticosteroids are handled through pharmacokinetic pathways similar to systemically administered corticosteroids. Corticosteroids are bound to plasma proteins in varying degrees. Corticosteriods are metabolized primarily in the liver and are then excreted by the kidneys. Some of the topical corticosteroids and their metabolites are also excreted into the bile.
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| dailymed-instance:activeIng... | |
| dailymed-instance:contraind... |
Topical corticosteroids are contraindicated in those patients with a history of hypersensitivity to any of the components of the preparation.
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| dailymed-instance:supply |
Triamcinolone Acetonide Cream USP and Triamcinolone Acetonide Ointments USP are supplied as follows:0.025%: 15 and 80 g tubes and 1 lb and 5 lb jars.0.1%: 15 and 80 g tubes and 1 lb and 5 lb jars.0.5%: 15 g tubes Store at controlled room temperature 15��to 30��C (59��to 86��F).
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| dailymed-instance:activeMoi... | |
| dailymed-instance:inactiveI... |
dailymed-ingredient:cetyl_alcohol,
dailymed-ingredient:cetyl_esters_wax,
dailymed-ingredient:glyceryl_monostearate,
dailymed-ingredient:isopropyl_plamitate,
dailymed-ingredient:polysorbate_60,
dailymed-ingredient:propylene_glycol,
dailymed-ingredient:sorbic_acid,
dailymed-ingredient:sorbitan_monostearate,
dailymed-ingredient:water
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| dailymed-instance:overdosag... |
Topically applied corticosteroids can be absorbed in sufficient amounts to produce systemic effects .
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| dailymed-instance:genericMe... |
Triamcinolone Acetonide
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| dailymed-instance:fullName |
Triamcinolone Acetonide (Cream)
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| dailymed-instance:adverseRe... |
The following local adverse reactions are reported infrequently with topical corticosteroids, but may occur more frequently with the use of occlusive dressings. These reactions are listed in an approximate decreasing order of occurrence: Burning, Itching, Irritation, Dryness, Folliculitis, Hypertrichosis, Acneiform eruptions, Hypopigmentation, Perioral dermatitis, Allergic contact dermatitis, Maceration of the skin, Secondary infection, Skin atrophy, Striae and Miliaria.
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| dailymed-instance:indicatio... |
Topical corticosteroids are indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.
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| dailymed-instance:represent... | |
| dailymed-instance:routeOfAd... | |
| dailymed-instance:name |
Triamcinolone Acetonide
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