Source:http://www4.wiwiss.fu-berlin.de/dailymed/resource/drugs/1267
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Desonide (Ointment)
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| dailymed-instance:dosage |
Desonide Ointment should be applied to the affected area as a thin film from two to four times daily depending on the severity of the condition. As with other corticosteroids, therapy should be discontinued when control is achieved. If no improvement is seen within 2 weeks, reassessment of diagnosis may be necessary. Desonide Ointment should not be used with occlusive dressings.
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| dailymed-instance:descripti... |
Desonide Ointment contains desonide (Pregna-1,4-diene-3,20-dione,11,21-dihydroxy-16, 17-[(1-methylethylidene)bis(oxy)]-, (11��,16��)) a synthetic corticosteroid for topical dermatologic use. The corticosteroids constitute a class of primary synthetic steroids used topically as anti-inflammatory and antipruritic agents. Chemically, desonide, the active ingredient in Desonide Ointment, is CHO. It has the following structural formula: Desonide has the molecular weight of 416.51. It is a white to off-white powder. The solubility of desonide in distilled water saturated with ether is 184 mg/L. Each gram of Desonide Ointment contains 0.5 milligrams of desonide microdispersed in a base of white petrolatum.
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| dailymed-instance:clinicalP... |
Pharmacokinetics: The extent of percutaneous absorption of topical corticosteroids is determined by many factors including the vehicle and the integrity, of the epidermal barrier. Occlusive dressings with hydrocortisone for up to 24 hours have not been demonstrated to increase penetration; however, occlusion of hydrocortisone for 96 hours markedly enhances penetration. Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin may increase percutaneous absorption. Studies performed with Desonide Ointment indicate that it is in the low range of potency as compared with other topical corticosteroids.
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| dailymed-instance:contraind... |
Desonide Ointment is contraindicated in those patients with a history of hypersensitivity to any of the components of the preparation.
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| dailymed-instance:supply |
Desonide Ointment, 0.05% is supplied in 15 and 60 gram tubes. Store between 15��and 30��C (59��and 86��F).
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| dailymed-instance:genericDr... | |
| dailymed-instance:activeMoi... | |
| dailymed-instance:inactiveI... | |
| dailymed-instance:overdosag... |
Topically applied Desonide Ointment can be absorbed in sufficient amounts to produce systemic effects .
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| dailymed-instance:genericMe... |
Desonide
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| dailymed-instance:fullName |
Desonide (Ointment)
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| dailymed-instance:adverseRe... |
In controlled clinical trials, the total incidence of adverse reactions associated with the use of Desonide Ointment was approximately 6 %. These were erythema, induration, pruritus, irritation, oiliness, and peripheral edema. The following additional local adverse reactions have been reported infrequently with topical corticosteroids, and they may occur more frequently with the use of occlusive dressings and higher potency corticosteroids. These reactions are listed in approximate decreasing order of occurrence: dryness, folliculitis, acneiform eruptions, perioral dermatitis, allergic contact dermatitis, secondary infection, skin atrophy, striae, miliaria, burning and hypopigmentation.
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| dailymed-instance:indicatio... |
Desonide Ointment is a low potency corticosteroid indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid responsive dermatoses. It should not be used for longer than two weeks unless directed by a physician.
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| dailymed-instance:name |
Desonide
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