Source:http://www4.wiwiss.fu-berlin.de/dailymed/resource/drugs/1231
| Predicate | Object |
|---|---|
| rdf:type | |
| rdfs:label |
Dibenzyline (Capsule)
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| dailymed-instance:dosage |
The dosage should be adjusted to fit the needs of each patient.
Small initial doses should be slowly increased
until the desired effect is obtained or the side effects from blockade become
troublesome. After each increase, the patient
should be observed on that level before instituting another increase.
The dosage should be carried to a point where symptomatic relief and/or objective
improvement are obtained, but not so high that the side effects from blockade
become troublesome. Initially, 10 mg of Dibenzyline
(phenoxybenzamine hydrochloride) twice a day. Dosage should be increased every
other day, usually to 20 to 40 mg 2 or 3 times a day, until an optimal dosage
is obtained, as judged by blood pressure control. Long-term use of phenoxybenzamine is not recommended
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| dailymed-instance:clinicalP... |
Dibenzyline (phenoxybenzamine hydrochloride) is a long-acting, adrenergic, alpha-receptor-blocking
agent, which can produce and maintain "chemical sympathectomy" by oral administration. It increases blood flow to the skin, mucosa and abdominal
viscera, and lowers both supine and erect blood pressures. It has no effect
on the parasympathetic system. Twenty to 30 percent of orally administered phenoxybenzamine appears to be absorbed in the active
form.�� The half-life of orally administered
phenoxybenzamine hydrochloride is not known; however, the half-life of intravenously
administered drug is approximately 24 hours. Demonstrable effects with intravenous
administration persist for at least 3 to 4 days, and the effects of daily
administration are cumulative for nearly a week.��
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| dailymed-instance:activeIng... | |
| dailymed-instance:supply |
Dibenzyline (phenoxybenzamine hydrochloride) capsules, 10 mg, in bottles of 100 (NDC 65197-001-01).
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| dailymed-instance:activeMoi... | |
| dailymed-instance:inactiveI... | |
| dailymed-instance:genericMe... |
Phenoxybenzamine Hydrochloride
|
| dailymed-instance:fullName |
Dibenzyline (Capsule)
|
| dailymed-instance:adverseRe... |
The following adverse reactions have been observed, but there are insufficient data to support an estimate of their frequency. Autonomic Nervous System:Postural hypotension, tachycardia, inhibition of ejaculation, nasal congestion, miosis. These so-called "side effects" are actually evidence of adrenergic blockade and vary according to the degree of blockade. Miscellaneous: Gastrointestinal irritation, drowsiness, fatigue.
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| dailymed-instance:represent... | |
| dailymed-instance:routeOfAd... | |
| dailymed-instance:name |
Dibenzyline
|