Source:http://www4.wiwiss.fu-berlin.de/dailymed/resource/drugs/1206
Predicate | Object |
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rdf:type | |
rdfs:label |
Acetic Acid (Irrigant)
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dailymed-instance:dosage |
0.25% Acetic Acid Irrigation, USP may be administered by
gravity drip via an administration set connected to an indwelling urethral
catheter designed for continuous or intermittent two-way flow. A disposable
dispensing set should be used. A bulb or piston syringe may be used for periodic
irrigation of an indwelling catheter. For continuous
or intermittent irrigation, the rate of administration will correspond roughly
to the rate of urine flow and should be adjusted to maintain a urinary effluent
pH of 4.5 to 5.0. Nitrazine or other pH paper may be used to monitor pH, preferably
at least four times daily. Drip rate should be adjusted as necessary to maintain
desired pH; increasing flow rate reduces pH value and vice versa. With continuous
or intermittent irrigation, each patient will require a volume of approximately
500 to 1500 mL per 24 hours. For periodic irrigation
of an indwelling catheter to maintain patency, about 50 mL is required for
each irrigation and may be administered using a bulb or piston syringe for
injection and aspiration as often as desired. Parenteral
drug products should be inspected visually for particulate matter and discoloration
prior to administration, whenever solution and container permit. See PRECAUTIONS.
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dailymed-instance:descripti... |
0.25% Acetic Acid Irrigation, USP, is a sterile, nonpyrogenic
aqueous solution of Glacial Acetic Acid, USP for irrigation of the urinary
bladder by the transurethral route (NOT FOR TUR). Each 100 mL contains 250
mg of Glacial Acetic Acid, in water for injection. The
solution is hypotonic, 42 mOsmol/liter (calc.), in relation to the extracellular
fluid compartment of the body (280 mOsmol/liter) and has a pH of 3.1 (2.8
to 3.4). Other than the active ingredient, acetic acid,
the solution contains no bacteriostat, antimicrobial agent or added buffer
and is intended only for use as a single-dose irrigation. When smaller volumes
are required the unused portion should be discarded. The
solution is a urinary bladder antimicrobial, acidifying irrigant. Glacial
Acetic Acid, USP is chemically designated acetic acid (CHO)
a liquid miscible with water. It has the following structural formula: CHCOOH Water
for Injection is chemically designated HO. The
semi-rigid container is fabricated from a specially formulated polyolefin.
It is a copolymer of ethylene and propylene. The container requires no vapor
barrier to maintain the proper drug concentration. Solutions
in contact with the plastic container may leach out certain chemical components
from the plastic in very small amounts; however, biological testing was supportive
of the safety of the plastic container materials. Exposure
to temperatures above 25��C/77��F during transport and storage will
lead to minor losses in moisture content. Higher temperatures lead to greater
losses. It is unlikely that these minor losses will lead to clinically significant
changes within the expiration period.
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dailymed-instance:clinicalP... |
Irrigation of the urinary bladder with acetic acid solution
in a concentration of 0.25% has been shown to exert an antimicrobial action
against a variety of microorganisms (especially ammonia-forming bacteria)
that frequently gain access to the urinary bladder in patients who require
prolonged indwelling urethral catheterization. Its antimicrobial action is
dependent on administration via the indwelling catheter at a sufficient rate
(continuous or intermittent) to maintain an effluent pH of at least 5.0. Maintenance
of low pH of bladder urine also helps reduce formation of calcium encrustations
in the indwelling catheter.
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dailymed-instance:activeIng... | |
dailymed-instance:contraind... |
NOT FOR INJECTION BY USUAL PARENTERAL ROUTES. This
solution is contraindicated for irrigation during transurethral surgical procedures.
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dailymed-instance:supply |
0.25% Acetic Acid Irrigation, USP is supplied in single-dose
irrigation containers as follows: Exposure of pharmaceutical products to heat should be minimized.
Avoid excessive heat. Protect from freezing. Store at 20 to 25��C (68
to 77��F). [See USP Controlled Room Temperature.] HOSPIRA, INC., LAKE FOREST,
IL 60045 USA
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dailymed-instance:genericDr... | |
dailymed-instance:activeMoi... | |
dailymed-instance:inactiveI... | |
dailymed-instance:possibleD... |
diseasome-diseases:1023,
diseasome-diseases:1025,
diseasome-diseases:1205,
diseasome-diseases:1428,
diseasome-diseases:2616,
diseasome-diseases:2617,
diseasome-diseases:2811,
diseasome-diseases:2835,
diseasome-diseases:2838,
diseasome-diseases:3833,
diseasome-diseases:3834,
diseasome-diseases:3842,
diseasome-diseases:4188,
diseasome-diseases:516,
diseasome-diseases:614,
diseasome-diseases:631,
diseasome-diseases:633,
diseasome-diseases:79
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dailymed-instance:precautio... |
If pain or hematuria should occur during irrigation, it should
be discontinued and the patient re-evaluated. Do not
use unless solution is clear, seal is intact and container is undamaged. Discard
unused portion.<br/>Carcinogenesis, Mutagenesis, Impairment of Fertility:: Studies with Acetic Acid Irrigation, USP have not been performed
to evaluate carcinogenic potential, mutagenic potential, or effects on fertility.<br/>Nursing Mothers:: Caution should be exercised when Acetic Acid Irrigation,
USP is administered to a nursing woman.<br/>Pregnancy:: Teratogenic Effects. Pregnancy
Category C. Animal reproduction studies have not been conducted with Acetic
Acid Irrigation, USP. It is also not known whether Acetic Acid Irrigation,
USP can cause fetal harm when administered to a pregnant woman or can affect
reproduction capacity. Acetic Acid Irrigation, USP should be given to a pregnant
woman only if clearly needed.<br/>Pediatric Usage:: The safety and effectiveness have not been established. Its
limited use in pediatric patients has been inadequate to fully define proper
dosage and limitations for use.
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dailymed-instance:overdosag... |
Systemic absorption is unlikely unless there are open lesions
of the bladder mucosa that have gone undetected. In such event, discontinue
the irrigation, evaluate the patient for possible systemic acidosis, intravascular
hemolysis and circulatory overload and institute appropriate countermeasures
as indicated. See WARNINGS, PRECAUTIONS and ADVERSE REACTIONS. Oral
LDin mice: 5 g/kg.
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dailymed-instance:genericMe... |
Acetic Acid
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dailymed-instance:fullName |
Acetic Acid (Irrigant)
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dailymed-instance:adverseRe... |
Systemic acidosis has been reported in patients receiving
urinary bladder irrigation with 0.25% acetic acid solution. Urologic pain
and hematuria have been reported in patients receiving urinary bladder irrigation
with 0.25% acetic acid solution.
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dailymed-instance:warning |
FOR IRRIGATION ONLY. NOT FOR INJECTION.
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dailymed-instance:indicatio... |
0.25% Acetic Acid Irrigation, USP is indicated as a constant
or intermittent bladder rinse to help prevent the growth and proliferation
of susceptible urinary pathogens (especially ammonia-forming bacteria) in
the management of patients who require prolonged placement of an indwellingurethral catheter. It also may be used for periodic irrigation of an indwelling
catheter to help maintain patency by reducing the formation of calcium encrustations.
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dailymed-instance:represent... | |
dailymed-instance:routeOfAd... | |
dailymed-instance:name |
Acetic Acid
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