Source:http://www4.wiwiss.fu-berlin.de/dailymed/resource/drugs/114
| Predicate | Object |
|---|---|
| rdf:type | |
| rdfs:label |
Carmol HC (Cream)
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| dailymed-instance:dosage |
CARMOL HC (Hydrocortisone Acetate Cream USP, 1%) is generally applied to the affected area as a thin film two to four times daily, depending on the severity of the condition. Occlusive dressings may be used for the management of psoriasis or recalcitrant conditions. If an infection develops, the use of occlusive dressings should be discontinued and appropriate antimicrobial therapy instituted.
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| dailymed-instance:descripti... |
CARMOL HC is intended for topical administration. The active component is the corticosteroid hydrocortisone acetate, which has the chemical name pregn-4-ene-3, 20-dione, 21-(acetyloxy)-11, 17-dihydroxy-, (11��)-. It has the following chemical structure. Each gram of the cream contains 10 mg Hydrocortisone Acetate USP, in a water-washable vanishing cream base containing urea (10%), purified water, stearic acid, propylene glycol, isopropyl myristate, isopropyl palmitate, PPG-26 oleate, sodium laureth sulfate, triethanolamine, xanthan gum, sodium metabisulfite, cetyl alcohol, edetate disodium, carbomer with hypoallergenic perfume. It is nonocclusive, and contains no mineral oil, petrolatum, lanolin, or parabens.
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| dailymed-instance:clinicalP... |
Topical corticosteroids share anti-inflammatory, anti-pruritic and vasoconstrictive actions. The mechanism of anti-inflammatory activity of the topical corticosteroids is unclear. Various laboratory methods, including vasoconstrictor assays, are used to compare and predict potencies and/or clinical efficacies of the topical corticosteroids. There is some evidence to suggest that a recognizable correlation exists between vasoconstrictor potency and therapeutic efficacy in man.<br/>Pharmacokinetics: The extent of percutaneous absorption of topical corticosteroids is determined by many factors including the vehicle, the integrity of the epidermal barrier, and the use of occlusive dressings. The topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin increase percutaneous absorption. Occlusive dressings substantially increase the percutaneous absorption of topical corticosteroids. Thus, occlusive dressings may be a valuable therapeutic adjunct for treatment of resistant dermatoses. Once absorbed through the skin, topical corticosteroids are handled through pharmacokinetic pathways similar to systemically administered corticosteroids. Corticosteroids are bound to plasma proteins in varying degrees. Corticosteroids are metabolized primarily in the liver and are then excreted by the kidneys. Some of the topical corticosteroids and their metabolites are also excreted into the bile.
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| dailymed-instance:activeIng... | |
| dailymed-instance:contraind... |
Topical corticosteroids are contraindicated in those patients with a history of hypersensitivity to any of the components of the preparation.
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| dailymed-instance:supply |
CARMOL HC (Hydrocortisone Acetate Cream USP, 1%) is supplied in: 1 oz. (28 g) tube NDC 10337-550-52 3 oz. (85 g) tube NDC 10337-550-19 Store at controlled room temperature 15��-30��C (59��-86��F). Protect from freezing. Pharmacist: Dispense in tight containers as specified in USP.
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| dailymed-instance:activeMoi... | |
| dailymed-instance:inactiveI... |
dailymed-ingredient:PPG-26_oleate,
dailymed-ingredient:carbomer_with_hypoallergenic_perfume,
dailymed-ingredient:cetyl_alcohol,
dailymed-ingredient:edetate_disodium,
dailymed-ingredient:isopropyl_myristate,
dailymed-ingredient:isopropyl_palmitate,
dailymed-ingredient:propylene_glycol,
dailymed-ingredient:sodium_laureth_sulfate,
dailymed-ingredient:sodium_metabisulfite,
dailymed-ingredient:stearic_acid,
dailymed-ingredient:triethanolamine,
dailymed-ingredient:urea,
dailymed-ingredient:water,
dailymed-ingredient:xanthan_gum
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| dailymed-instance:overdosag... |
Topically applied corticosteroids can be absorbed in sufficient amounts to produce systemic effects.
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| dailymed-instance:genericMe... |
hydrocortisone acetate
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| dailymed-instance:fullName |
Carmol HC (Cream)
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| dailymed-instance:adverseRe... |
The following local adverse reactions are reported infrequently with topical corticosteroids, but may occur more frequently with use of occlusive dressings. These reactions are listed in an approximate decreasing order of occurrence beginning with column 1:
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| dailymed-instance:warning |
Contains sodium metabisulfite, a sulfite that may cause allergic-type reactions including anaphylactic symptoms and life-threatening or less severe asthmatic episodes in certain susceptible people. The overall prevalence of sulfite sensitivity in the general population is unknown and probably low. Sulfite sensitivity is seen more frequently in asthmatic than in nonasthmatic people.
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| dailymed-instance:represent... | |
| dailymed-instance:routeOfAd... | |
| dailymed-instance:name |
Carmol HC
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